全文获取类型
收费全文 | 4120篇 |
免费 | 306篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 42篇 |
儿科学 | 148篇 |
妇产科学 | 82篇 |
基础医学 | 554篇 |
口腔科学 | 64篇 |
临床医学 | 419篇 |
内科学 | 975篇 |
皮肤病学 | 75篇 |
神经病学 | 418篇 |
特种医学 | 314篇 |
外国民族医学 | 2篇 |
外科学 | 454篇 |
综合类 | 124篇 |
一般理论 | 10篇 |
预防医学 | 280篇 |
眼科学 | 75篇 |
药学 | 207篇 |
中国医学 | 5篇 |
肿瘤学 | 194篇 |
出版年
2021年 | 74篇 |
2020年 | 40篇 |
2019年 | 62篇 |
2018年 | 79篇 |
2017年 | 60篇 |
2016年 | 80篇 |
2015年 | 77篇 |
2014年 | 95篇 |
2013年 | 160篇 |
2012年 | 209篇 |
2011年 | 194篇 |
2010年 | 133篇 |
2009年 | 136篇 |
2008年 | 156篇 |
2007年 | 182篇 |
2006年 | 184篇 |
2005年 | 171篇 |
2004年 | 137篇 |
2003年 | 116篇 |
2002年 | 106篇 |
2001年 | 99篇 |
2000年 | 94篇 |
1999年 | 101篇 |
1998年 | 68篇 |
1997年 | 56篇 |
1996年 | 58篇 |
1995年 | 60篇 |
1994年 | 36篇 |
1993年 | 40篇 |
1992年 | 75篇 |
1991年 | 51篇 |
1990年 | 81篇 |
1989年 | 71篇 |
1988年 | 72篇 |
1987年 | 72篇 |
1986年 | 70篇 |
1985年 | 60篇 |
1984年 | 52篇 |
1983年 | 42篇 |
1982年 | 33篇 |
1981年 | 36篇 |
1979年 | 49篇 |
1978年 | 38篇 |
1977年 | 32篇 |
1976年 | 32篇 |
1975年 | 35篇 |
1974年 | 37篇 |
1973年 | 56篇 |
1972年 | 35篇 |
1967年 | 33篇 |
排序方式: 共有4442条查询结果,搜索用时 15 毫秒
101.
Improved quality of life after lung volume reduction surgery. 总被引:3,自引:0,他引:3
J Hamacher S Büchi C L Georgescu U Stammberger R Thurnheer K E Bloch W Weder E W Russi 《The European respiratory journal》2002,19(1):54-60
Lung volume reduction surgery (LVRS) improves dyspnoea, pulmonary function, and physical performance in patients with severe pulmonary emphysema. This study investigated the impact of LVRS on health-related quality of life (HRQL) over a 2-yr period following surgery. Thirty-nine consecutive patients were prospectively assessed before LVRS, and followed over 24 months postoperatively. The assessments included pulmonary function, dyspnoea (Medical Research Council (MRC) dyspnoea score), 6-min walking distance (6MWD) and HRQL using the Short Form 36-item questionnaire (SF-36). Several domains of SF-36 improved considerably over 2 yrs after surgery: Physical Functioning: 39 +/- 4 (mean +/- SEM) versus 16 +/- 2 (p<0.01); Vitality: 51 +/- 3 versus 32 +/- 3 (p<0.01); Social Functioning: 72 +/- 4 versus 51 +/- 5 (p<0.01). Also, improvements in pulmonary function (forced expiratory volume in one second (FEV1): 27 +/- 1% predicted, residual volume (RV)/total lung capacity (TLC): 0.65 +/- 0.01), 6 MWD (274 +/- 16 m) and dyspnoea (MRC: 3.9 +/- 01) were sustained for up to 2 yrs after LVRS (FEV1 36 +/- 2% pred, RV/TLC: 0.58 +/- 0.02; 6 MWD: 342 +/- 19 m; MRC: 2.0 +/- 0.2; p<0.05). In patients with severe emphysema, lung volume reduction surgery had positive effects on health-related quality of life and pulmonary function over 2 yrs. 相似文献
102.
Renovascular disease is a complex disorder, the most common causes of which are fibromuscular dysplasia and atherosclerotic disease. It usually presents in one of three forms: asymptomatic renal artery stenosis, renovascular hypertension, or ischemic nephropathy. This complexity often makes diagnostic and management decisions difficult. This review will be presented in two parts. In Part I, the authors will discuss when to consider and how to go about making the diagnosis. In Part II (in a future issue of The JCH ), the authors discuss the management of renovascular disease. The clinical index of suspicion remains paramount in setting the diagnostic strategy. Although it is subject to certain limitations, conventional contrast angiography is usually considered the gold standard in confirming the diagnosis. In addition, there are a number of available noninvasive tests that can aid in decision making. These tests can be divided into those that detect the anatomic presence of a stenosis and those that identify the functional consequences of the renal artery obstruction.
No one study is appropriate for every patient. A diagnostic algorithm is proposed at the conclusion of this review. 相似文献
No one study is appropriate for every patient. A diagnostic algorithm is proposed at the conclusion of this review. 相似文献
103.
104.
105.
Klara Brixius Persephone Savvidou-Zaroti Uwe Mehlhorn Wilhelm Bloch Evangelia G. Kranias Robert H. G. Schwinger 《Basic research in cardiology》2002,97(7)
In human failing myocardium, an increased Ca 2+-sensitivity of myofilament tension development has been described in Triton X skinned cardiac myocytes compared to cardiomyocytes obtained from non-failing human donor hearts. The present study aimed to investigate whether there are functional implications of the increased Ca 2+-sensitivity in heart failure and whether alterations of myofilament function are already obvious at earlier stages of heart failure, such as in cardiac hypertrophy or whether alterations of the intracellular Ca 2+-homeostasis are able to induce alterations in myofilament function. Ca 2+-activated tension development was measured in Triton X-skinned fibers from human failing and non-failing myocardium. Ca 2+-sensitivity of myofilament tension development was significantly shifted to the left in human failing myocardium. Plots of diastolic free Ca 2+ versus diastolic tension development showed that in a range of similar diastolic Ca 2+-concentrations, diastolic tension was significantly enhanced in the failing hearts. The Ca 2+/tension relationship was shifted to the right in Triton X-skinned fiber preparations from transgenic renin overexpressing rats (TG(mREN2)27), shown to have concentric hypertrophy. In addition, the Ca 2+/tension relationship was unchanged in phospholamban knock-out mice with an increased systolic Ca 2+ (and enhanced diastolic Ca 2+-load). It is concluded that the increased Ca 2+-sensitivity of myofilament tension observed in single cardiomyocytes from failing human myocardium may be a phenomenon also present in multicellular preparations and may contribute to the diastolic dysfunction observed in human heart failure. Alterations of myofilament function occur at very early stages of heart failure and may be species dependent, or dependent on intracellular free Ca 2+-levels. 相似文献
106.
Ronan Roussel Pierre G. Carlier Jean-Jacques Robert Gilberto Velho Gilles Bloch 《Proceedings of the National Academy of Sciences of the United States of America》1998,95(3):1313-1318
The muscle intracellular (IC) free glucose concentration and the rate of muscle glycogen synthesis were measured by using in vivo 13C and 31P NMR spectroscopy in normal volunteers under hyperinsulinemic (≈300 pM) clamp conditions at the following three plasma glucose levels: euglycemia (≈6 mM), mild (≈10 mM), and high (≈16 mM) hyperglycemia. In keeping with biopsy studies, muscle IC free glucose concentration at euglycemia (−0.03 ± 0.03 mmol/kg of muscle, mean ± SEM, n = 10) was not statistically different from zero. A small but statistically significant amount of IC free glucose was observed during mild and high hyperglycemia: 0.15 ± 0.08 (n = 5) and 0.43 ± 0.20 mmol/kg of muscle (n = 5), respectively. Muscle glycogen synthesis rate, in mmol per kg of muscle per min, was 111 ± 11 at euglycemia (n = 10), 263 ± 29 during mild hyperglycemia (n = 5), and 338 ± 42 during high hyperglycemia (n = 5), these three rates being significantly different from each other. As previous in vitro and in vivo studies, these rates suggest a Km (concentration at which unidirectional glucose transport reaches half-maximal rate) of the muscle glucose transport system in the 15–25 mM range under hyperinsulinemic conditions. The low concentrations of muscle IC free glucose observed under hyperinsulinemic conditions were interpreted, with this estimate and in the framework of metabolic control theory, as glucose transport being the predominant step controlling muscle glucose flux not only at euglycemia but also during hyperglycemia. 相似文献
107.
108.
背景目前已开展了对重性精神病患者进提供连续性服务的研究。目的探讨基层对有抑郁症风险患者提供连续性服务的水平,并与对心力衰竭患者的服务水平进行对比。方法采用抑郁症风险患者与心力衰竭患者对比的探索性研究。采用患者问卷评估服务的持续性,包含如下内容:(1)联系的服务提供者数(个人连续性);(2)诊所内服务提供者之间的合作(团队连续性)(6个项目,分数1~5分);(3)诊所外全科医师与服务提供者之间的合作(跨界连续性)(4个项目,分数1~5分)。结果大多数抑郁症风险患者在过去1年中寻遍整个服务提供界联系了几个服务提供者,曾遇到过高水平团队连续性服务及低水平跨界连续性服务。在诊所中可接触到的不同服务提供者要明显多于心力衰竭患者服务提供者(P<0.01)。抑郁症风险患者的服务提供者之间的合作更好一些,每项平均得分4.3分,心力衰竭患者得分为4.0分(P=0.03)。然而,跨界连续性服务方面正好相反:抑郁症风险患者每项平均得分3.5分,心力衰竭患者得分为4.0分(P=0.01)。结论抑郁症风险患者与心力衰竭患者之间的探索性对比显示:体验服务连续性方面的差距不大。对此还应行进一步分析。 相似文献
109.
The epidemiology of bacterial culture–positive and septic transfusion reactions at a large tertiary academic center: 2009 to 2016 下载免费PDF全文
110.
Safety study of 38 503 intravitreal ranibizumab injections performed mainly by physicians in training and nurses in a hospital setting 下载免费PDF全文