全文获取类型
收费全文 | 370篇 |
免费 | 25篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 8篇 |
妇产科学 | 1篇 |
基础医学 | 44篇 |
口腔科学 | 11篇 |
临床医学 | 21篇 |
内科学 | 82篇 |
皮肤病学 | 11篇 |
神经病学 | 12篇 |
特种医学 | 8篇 |
外科学 | 114篇 |
综合类 | 6篇 |
预防医学 | 16篇 |
眼科学 | 5篇 |
药学 | 20篇 |
中国医学 | 2篇 |
肿瘤学 | 32篇 |
出版年
2024年 | 1篇 |
2023年 | 6篇 |
2022年 | 7篇 |
2021年 | 20篇 |
2020年 | 12篇 |
2019年 | 8篇 |
2018年 | 11篇 |
2017年 | 10篇 |
2016年 | 9篇 |
2015年 | 10篇 |
2014年 | 13篇 |
2013年 | 13篇 |
2012年 | 26篇 |
2011年 | 29篇 |
2010年 | 15篇 |
2009年 | 10篇 |
2008年 | 20篇 |
2007年 | 33篇 |
2006年 | 28篇 |
2005年 | 24篇 |
2004年 | 24篇 |
2003年 | 12篇 |
2002年 | 13篇 |
2001年 | 6篇 |
2000年 | 5篇 |
1999年 | 4篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 4篇 |
1991年 | 4篇 |
1990年 | 1篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1983年 | 1篇 |
1981年 | 1篇 |
1975年 | 1篇 |
1973年 | 2篇 |
1970年 | 1篇 |
排序方式: 共有398条查询结果,搜索用时 15 毫秒
71.
72.
Chua AW Gan SU Ting Y Fu Z Lim CK Song C Sabapathy K Phan TT 《Journal of dermatological science》2011,64(3):199-209
Background
Current evidence suggests the potential role of Wnt signalling in keloids pathogenesis but such literature remains scanty. We hypothesize that Wnt signalling is upregulated in keloid fibroblasts (KFs) and this promotes cellular growth, migration and extracellular matrix (ECM) production in such fibroblasts.Objectives
To verify the downregulation of secreted frizzled-related protein 1 (SFRP1), a Wnt inhibitor and test KFs sensitivity to Wnt3a treatment compared to NFs in terms of activation of Wnt/β-catenin, cellular growth, migration and ECM expressions. Next, to investigate if ectopic expression of SFRP1 and treatment of quercetin in KFs can reverse their phenotypes.Methods
Quantitative Real-time PCR and western blotting were used to verify SFRP1 expression in NFs and KFs. The fibroblasts were tested with Wnt3a conditioned media and its effects were tested for (1) the cells’ sensitivity to direct Wnt signalling via the activation of TCF reporter assay and protein expression of β-catenin, (2) cellular growth, (3) cell migration and (4) expressions of ECM components. Finally KFs were stably transduced with SFRP1 and treated with 2 doses of quercetin.Results
Lower levels of SFRP1 were confirmed at mRNA and protein levels in KFs which partly explained their sensitivity to Wnt3a treatment in terms of higher Wnt activation, cellular growth and fibronectin expression. Interestingly, Wnt3a did not promote higher cell migration rate and increase in collagen I expression. Ectopic expression of SFRP1 and quercetin treatment was able to mitigate Wnt3a-mediated phenotype of KFs.Conclusions
Using SFRP1 or inhibitors of Wnt signalling might be one of the therapeutic solutions to treat keloid scarring. 相似文献73.
74.
75.
76.
77.
78.
79.
Ashish Chawla Surendran Rajendran Wai Heng Yung Suresh Balasubramanian Babu Wilfred C. Peh 《Emergency radiology》2016,23(4):405-412
Acute aortic syndrome is a group of life-threatening diseases of the thoracic aorta that usually present to the emergency department. It includes aortic dissection, aortic intramural hematoma, and penetrating aortic ulcer. Rare aortic pathologies of aorto-esophageal fistula and mycotic aneurysm may also be included in this list. All these conditions require urgent treatment with complex clinical care and management. Most patients who present with chest pain are evaluated with a chest radiograph in the emergency department. It is important that maximum diagnostic information is extracted from the chest radiograph as certain signs on the chest radiograph are extremely useful in pointing towards the diagnosis of acute aortic syndrome. 相似文献
80.