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101.
阳江高本底地区居民健康流行病学调查数据库与统计分析方法 总被引:1,自引:0,他引:1
目的 研究应用计算机数据库技术及先进统计分析方法,对阳江高本底地区10多万人20余年的健康随访研究资料和剂量学调查资料进行储存、管理和分析。方法 通过调研和比较分析,确定采用Foxbase系列数据库管理系统按专题建立数据库,借助于ID号实现记录连接;一般统计分析由SAS完成;交叉分组人年列表由Epicure中的Datab完成;癌症相对危险分析用AMFIT程序。结果 建立了40MB的各专题研究库,主要包括:10余万人的人口学数据库(1979~1995)、1.2万人的死因数据库(1979~1995)和526个村庄6783户、5273人的剂量数据库。提出了动态群组研究资料(1979~1986)与固定群组研究资料(1987~1995)的合并方法:首选方法是建立假想的基于记录连接的以1979年为起点的(固定)群组。另一方法是将不同阶段群组研究的人年表分层直接相加。计算了每个成员基于卧室内、起居室内、室外村平均剂量率与性别-年龄别居留因子的累积剂量。完成了以性别、atainedage、随访年代及剂量交叉分组的人年列表,对癌症死亡资料(1979~1990)进行了危险分析。结论 应用计算机数据库管理系统与统计分析技术使阳江高本底地区研 相似文献
102.
Good regulation of acupuncture in simple obesity patients with stomach-intestine excessive heat type 下载免费PDF全文
In order to investigate the regulatory effect of acupuncture on obesity patients with the Stomach-Intestine Excessive Heat Type, the pre-acupunctureal and post-acupunctural obesity index and biochemical indices of 718 simple obesity patients with Stomach-Intestine Excessive Heat Type were observed. It was showed that the marked weight loss effect was achieved in the cases by acupuncture, and the biochemical indices improved. It suggests that acupuncture had a optimal regulatory effect on the function of nerve, endocrine, digestion and energy metabolism. 相似文献
103.
104.
M K Sun 《Journal of the autonomic nervous system》1992,38(3):209-217
Electrical stimulation of the prefrontal cortex in anaesthetised, paralysed rats evokes transient hypotension. In this study we have endeavoured to determine whether this evoked response is mediated by the spinal cord-projecting vasomotor neurones of the rostroventrolateral medulla (RVL). The responses of RVL-spinal vasomotor neurones to electrical stimulation of the prefrontal cortex caused a period of inhibition of the neuronal activity in the majority of cases (11 out of 13 neurones tested, 85%) and a short period of excitation in the remaining 2 neurones (15%). The prefrontal cortex-evoked inhibition of RVL-spinal vasomotor neurones was eliminated by iontophoretic application of bicuculline, a GABAa receptor antagonist, to the RVL-spinal vasomotor neurones. Microinjection of 50 nl of bicuculline methiodide into the same area of the RVL where the neurones have been identified converted the prefrontal-evoked hypotension into a vasopressor response. These findings indicate that the hypotension evoked by stimulating the prefrontal cortex is mediated by GABAergic inhibition of the RVL-spinal vasomotor neurones. 相似文献
105.
Protein kinase C (PKC) is a family of at least seven closely related molecules (isozymes) that vary in terms of their requirements for activation and their distribution among cells of the brain. A striking example of this differential distribution is seen in the cerebellum, where Purkinje cells express PKC-I, an isozyme that is strongly activated by both phorbol ester (PE), and low doses of cis-unsaturated fatty acid (c-UFA), while granule cells predominantly express PKC-II, an isozyme that is strongly activated by PE but not c-UFA. Both Purkinje and granule cells have large, easily recorded voltage-gated K currents. These currents are attenuated by PKC activators in several other varieties of neuron. We hypothesized that the effects of these two PKC activators would be predicted by the distribution of the relevant PKC isozyme, and that the delayed outward rectifier current, IK, would be attenuated by both PE and c-UFA in Purkinje cells, but only by PE in granule cells. This hypothesis was confirmed in perforated-patch recordings. The attenuation produced by both activators could be blocked by application of a specific PKC inhibitor, RO-31-8220, and could not be mimicked by inert forms of PE or c-UFA. To our knowledge, this study represents the first report of an electrophysiological correlate of PKC isozyme distribution. 相似文献
106.
TPA (12-O-tetradecanoylphorbol-13-acetate), a potent tumor promoter, has been shown to stimulate or inhibit cell growth depending on the cell type investigated. We recently found that RT101 cells, a transformed mouse JB6 epidermal cell line, acquired a greater growth inhibition response to TPA during conventional subcultivation. The growth of low-passage RT101 cells was slightly inhibited by TPA in monolayer culture but stimulated in soft agar. In contrast, the growth of high-passage cells was greatly inhibited by TPA in both monolayer culture and in soft agar. Inhibition was dose dependent, directly correlated with protein kinase C-activating activities of tumor promoters, and was found to be reversible. TPA-treated high-passage cells were greatly reduced in volume, showed extensive abnormal mitoses, and were more susceptible to detachment. High-passage cells were also found to be less tumorigenic as indicated by in vivo tumorigenicity assay in nude mice. TPA treatment rendered cells still less tumorigenic in the case of both cell lines. The mechanism for acquisition of increased sensitivity to TPA of RT101 cells during subculture was investigated; it involved nonrandom DNA damage and detachment of nonviable cells. The results suggest the possibility that early-passage RT101 cells contained two subpopulations, one TPA-sensitive and one TPA-resistant population. Conventional subcultivation may have selected for the former subpopulation. The sensitive subpopulation may have been irreversibly inhibited as a result of TPA-induced cell killing, possibly apoptosis. 相似文献
107.
目的探讨输尿管镜气压弹道碎石治疗输尿管结石的效果。方法2004年2月~2005年3月,我们对185例输尿管结石(其中伴肾绞痛96例)采用输尿管镜取石或气压弹道碎石进行总结和分析。结果失败12例,其中6例改开放手术,6例术后3d行体外冲击波碎石。一次碎石成功率93.5%(173/185),其中上段结石为75.0%(24/32),中段为95.8%(46/48),下段为98.1%(103/105)。肾绞痛者成功率为100%(96/96)。术中输尿管损伤率2.9%(5/173),其中3例(1.7%)中转开放手术。术后肾绞痛1例。全组随访6~12个月,平均10.2月,无复发。结论输尿管镜气压弹道碎石安全有效,并发症少,是治疗输尿管中下段结石的首选方法,尤其对肾绞痛者疗效更好。 相似文献
108.
浅谈多媒体教学中存在的问题及对策 总被引:17,自引:2,他引:15
分析了目前多媒体教学中存在的一些问题,提出了一些提高多媒体教学质量的途径和方法。 相似文献
109.
110.
Wen Zhao Jian Sun Jia-Wei Zheng Jun Li Yue He Zhi-Yuan Zhang 《Otolaryngology--head and neck surgery》2006,135(5):758-764
OBJECTIVE: To study the effect of the cervical plexus and the accessory nerve to the function of the trapezius muscle. STUDY DESIGN AND SETTING: Eighteen adult male Sprague-Dawley rats were randomly divided into three groups. The neurotomies were performed in the left sides and the right sides served as within-subject controls. In group A, the accessory nerve was transected. The C2-5 were transected in group B, and both of the accessory nerve and C2-5 were cut in group C. The electrophysiologic, myophysiologic, and histologic changes of the muscles were measured. RESULTS: There were significant differences (P < 0.05) between the three groups in the recovery rates of the transverse area of the muscles. The CMAP recorded from the experimental sides in group B were similar to the control sides. The values of the maximum tension of the tetanus contraction between the two sides showed no differences either (P > 0.05). CONCLUSION: The accessory nerve supplies the most important motor input to the trapezius. Motor innervations of the cervical plexus are not very significant. 相似文献