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21.
Summary
In a 36-month prospective trial 21 patients with systemic sclerosis (diffuse systemic sclerosis 16 patients and 5 subjects with limited cutaneous subtype) were treated with D-penicillamine. In all patients with diffuse systemic sclerosis there was objective improvement. The degree and extent of skin involvement decreased significantly (p < 0.001), whereas no objective improvement was noted in patients with limited cutaneous subtype. Further, no systemic progression of the disease was observed during the study period. Our results suggest that a prolonged treatment with D-penicillamine in small doses is not only beneficial and effective but also free of side-effects, if used at an earlier stage. 相似文献
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23.
Crusted scabies is rare. It is a therapeutic challenge, as the common drugs used against scabies are unsatisfactory. The successful use of galenicals in a 10-year-old girl with crusted scabies is reported. 相似文献
24.
Kuruvila M Mathew T Sugathan P Nair LV 《Indian journal of dermatology, venereology and leprology》1998,64(3):146-149
Twenty patients with extensive psoriasis of more than three years duration not responding to conventional medical treatment were studied to assess the effect of dialysis. Ten patients were subjected to haemodialysis and ten to peritoneal dialysis. Patients were periodically assessed regarding responses by standard critera. At the end of six months 4/8 (50%) in haemodialysis group and 6/10(60%) in peritoned dialysis group showed improvement. One patient in haemodialysis group developed exfoliative dermatitis eleven days after onset of dialysis. In this study though a beneficial effect in psoriasis was noted following dialysis, the effect was temporary. 相似文献
25.
C Nagaraj N Sugathan N K Chakrabarti M V Narasimham 《The Journal of communicable diseases》1991,23(2):100-102
The study highlights the presence of chloroquine resistant Plasmodium falciparum strains in Kerala state, India for the first time. The emergence of chloroquine resistant P. falciparum in a low transmission area is dependent on the imported cases while build up of resistance is mainly due to persistence of resistant parasites which have more opportunities for transmission. 相似文献
26.
27.
Sasidharan CK Sugathan P Agarwal R Khare S Lal S Jayaram Paniker CK 《Indian journal of pediatrics》2005,72(1):17-21
Objective: Hand-Foot-and-Mouth Disease (HFMD) is a mild exanthematous illness seen worldwide, affecting mainly children under ten years
of age. The causative agents were initially Coxsackie virus type A 16 and related serotypes. The situation changed drastically
about thirty years ago with the advent of a new aetiological agent, Enterovirus type 71 (EV 71), which has caused very large
outbreaks with severe complications and many deaths.Methods: The authors report an outbreak of papulovesicular lesions on the skin and oral mucosa compatible with the diagnosis of HFMD
in children in and around Calicut in October 2003. Clinical and laboratory study in collaboration with the National Institute
of Communicable Diseases, Delhi. Eighty one children with the syndrome were examined and followed up from October 2003 to
February 2004, when the outbreak subsided.Result: The outbreak was mild and all children recovered within 1 to 2 weeks.Conclusion: Acute and convalescent paired serum samples collected from 19 patients were examined at the NICD for IgM antibody against
EV 71 by microneutralisation test in cell culture. All the paired samples tested showed significant rise in titre of antibodies,
confirming the diagnosis of EV 71 infection in each of them. 相似文献
28.
29.
Tuberculin test (purified protein derivative) is currently accepted as a standard investigation used in the diagnosis of tuberculosis (TB). Although the sensitivity of the test is reliable, a substantial number of those subjected to screening for TB by such test are cigarette smokers. This study is designed to investigate the effect of smoking on cell-mediated delayed-type cellular hypersensitivity (DTH) reaction by PPD. Prospective, case-control study was conducted at the Chest and TB unit of Chest Hospital Kuwait. The study population consisted of 357 healthy volunteers serving as controls and 200 in-patients under direct medical supervision and treatment for tuberculosis as cases. The mean age was 33.69 +/- 8.6 SD; 286 were current smokers and 271 were lifetime non-smokers. PPD test was done using 2TU RT23 SSI-Denmark on all subjects. Median PPD was significant among the cases (P=0.03) between smokers and non-smokers and was highly significant among the healthy controls (P<0.001). No significant difference was seen between median pack years of smoking and PPD levels among the patient group (P=0.264) but the difference was significant among the control group (P<0.001). Univariate analysis of variance (ANOVA) on PPD, taking into account age, pack years of smoking, ethnic groups and BCG scar showed sufficient response but was not statistically significant to all these factors. Smoking habit does not appear to influence the cutaneous delayed type hypersensitivity reaction by tuberculin skin test. 相似文献
30.
M A Sattar M al-Saffar R T Guindi T N Sugathan K Behbehani 《Annals of the rheumatic diseases》1990,49(3):147-149
Eighty five Arab patients with classical and definite rheumatoid arthritis were typed to determine the prevalence of HLA A, B, C, and DR antigens. A significant increase in the prevalence of HLA-A10, B8, B21, and DR3 was found in comparison with a control population matched for age and sex. HLA-DR5 was significantly decreased in the patient group. The classical association of HLA-DR4 with rheumatoid arthritis could not be confirmed in the Arab patients resident in Kuwait, supporting reported observations in different ethnic groups of associations with HLA antigens other than HLA-DR4 and indicating a heterogeneous genetic susceptibility to rheumatoid arthritis. 相似文献