全文获取类型
收费全文 | 2695篇 |
免费 | 161篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 50篇 |
儿科学 | 104篇 |
妇产科学 | 72篇 |
基础医学 | 403篇 |
口腔科学 | 16篇 |
临床医学 | 203篇 |
内科学 | 449篇 |
皮肤病学 | 65篇 |
神经病学 | 93篇 |
特种医学 | 35篇 |
外科学 | 246篇 |
综合类 | 198篇 |
一般理论 | 4篇 |
预防医学 | 192篇 |
眼科学 | 354篇 |
药学 | 175篇 |
中国医学 | 14篇 |
肿瘤学 | 184篇 |
出版年
2023年 | 17篇 |
2022年 | 60篇 |
2021年 | 89篇 |
2020年 | 67篇 |
2019年 | 48篇 |
2018年 | 66篇 |
2017年 | 38篇 |
2016年 | 65篇 |
2015年 | 82篇 |
2014年 | 101篇 |
2013年 | 143篇 |
2012年 | 173篇 |
2011年 | 170篇 |
2010年 | 119篇 |
2009年 | 71篇 |
2008年 | 152篇 |
2007年 | 150篇 |
2006年 | 111篇 |
2005年 | 112篇 |
2004年 | 121篇 |
2003年 | 116篇 |
2002年 | 109篇 |
2001年 | 79篇 |
2000年 | 94篇 |
1999年 | 70篇 |
1998年 | 30篇 |
1997年 | 15篇 |
1996年 | 16篇 |
1995年 | 16篇 |
1994年 | 18篇 |
1993年 | 10篇 |
1992年 | 24篇 |
1991年 | 30篇 |
1990年 | 30篇 |
1989年 | 18篇 |
1988年 | 21篇 |
1987年 | 16篇 |
1986年 | 13篇 |
1985年 | 14篇 |
1984年 | 10篇 |
1981年 | 7篇 |
1978年 | 8篇 |
1977年 | 9篇 |
1976年 | 9篇 |
1975年 | 10篇 |
1973年 | 10篇 |
1972年 | 9篇 |
1970年 | 7篇 |
1968年 | 11篇 |
1967年 | 7篇 |
排序方式: 共有2857条查询结果,搜索用时 0 毫秒
31.
R. Tudu J. Banerjee Md Habib S. Bandyopadhyay S. Biswas S. S. Kesh A. Maity S. Batabyal S. Polley 《Majallah-i ta?qīqāt-i dāmpizishkī-i īrān》2022,23(3):237
Background:Dogs are the favorite companion animals among humans. The close interaction between dogs and people increases the risk of antibiotic resistance spreading. Surveillance for antimicrobial resistance and the identification of ESBL-producing Escherichia coli as an indicator bacterium is an important tool for managing antimicrobial drug therapy. Aims:The present study targeted to identify and characterize ESBL-producing E. coli among dogs suffering from diarrhea in and around Kolkata. Methods:Isolation and identification of E. coli from dogs suffering from diarrhea (n=70) along with screening for the production of both ESBL and AmpC. The isolates were further characterized through antimicrobial resistance profiling, resistance genes (blaCTX-M, blaTEM, and blaSHV) screening, and phylogenetic group study. Results:Among the 70 isolates, 21 (30%) were confirmed ESBL producers. An antibiogram typing of ESBL-producing E. coli revealed that the majority of them were resistant to norfloxacin (85.7%) followed by tetracycline (61.90%), doxycycline (57.14%), piperacillin/tazobactam (52.38%), cotrimoxazole (47.62%), gentamicin (42.62%), amikacin (23.81%), and chloramphenicol (19.05%). Major resistance genes included blaCTX-M (100%), blaTEM (28.57%), and blaSHV (9.50%). The predominant phylogenetic groups were phylogroup A (76%) followed by phylogroup D (24%). Conclusion:The current investigation reported a high prevalence of both ESBL and AmpC β-lactamase (AmpC) producing E. coli, co-resistance to a distinct group of antibiotics, and co-existence of different ESBL genes in dogs. Our findings highlight the importance of diagnostic antimicrobial susceptibility testing for proper antimicrobial therapy and to prevent antimicrobial resistance from spreading to humans from dogs in Kolkata and the surrounding area.Key Words: Antibiotics, Dog, E. coli, ESBL, PCR 相似文献
32.
33.
Jeyasooriya Ramdoss Anupreeti Jain GN Thejesvi Jyotirmay Biswas 《Indian journal of ophthalmology》2022,70(7):2454
Purpose:To report the prevalence, clinical profile, investigations, and visual outcomes of sarcoid intermediate uveitis in a tertiary eye care center in South India.Methods: Retrospective, observational case series. Records of 29 patients with sarcoid intermediate uveitis were retrieved. Complete ophthalmic evaluation and systemic examination by a pulmonologist with appropriate laboratory investigations were done. Results were analyzed using SPSS software.Results: Mean age group was 42.14 ± 11.31 years. The bilateral presentation was more common and females were more affected than males. Anterior chamber cells and flares in 22.4% of cases (N = 11 eyes), posterior synechiae in 20.4% (N = 10 eyes), and both small and mutton fat keratic precipitates in 14.2% of cases (N = 7 eyes) were noted; only one eye had Busacca nodules similar to other granulomatous uveitis. Cystoid macular edemas were present in three eyes. Treatment with oral steroids and systemic immunosuppression resulted in good visual recovery. The mean presenting visual acuity in right and left eye were 0.2 and 0.3, respectively. The mean final visual acuity in right and left eye was 0.1 and 0.3, respectively.Conclusion: Sarcoid intermediate uveitis is quite common in a tuberculosis endemic country like India. A complete review of systems with appropriate investigations is essential to prevent visual complications. 相似文献
34.
Prabhakar Singh Amit Raj Abhishek Gupta Swetalina Pradhan Naila Aftab Saranya Biswas 《Indian journal of ophthalmology》2022,70(12):4470
Background:Steven–Johnson syndrome (SJS) is a serious disorder affecting the skin and mucous membrane, causing multiple flaccid bullae and purpuric rashes with sheet-like epithelial detachment including the ocular surface. The long-term outcomes following SJS are dismal and manifest as corneal vascularization, lid-wiper keratopathy, and severe dry eyes. The disease course can be modified if amniotic membrane graft is performed at the first week of disease, and the above-said complications can be avoided. This procedure thus not only decreases the morbidity but also improves the quality of life.Purpose:This video discusses the long-term sequelae of SJS which can be modified with timely intervention during the acute stage and thus significantly decreases morbidity.Synopsis:The video demonstrates the simple technique of amniotic membrane transplantation in the acute stage in SJS and its impact in long run.Highlights:There should be a low threshold for doing early amniotic membrane transplantation in patients with SJS with ocular surface involvement. Early intervention can change the disease course and decrease disease morbidity significantly.Video link: https://youtu.be/qgIiVcW56Oo 相似文献
35.
Shantha Balekudaru Deep Shah Vijaya Lingam Ronnie George Amala Elizabeth George Sudha K Ganesh Jyotirmay Biswas Parthopratim Dutta Majumder Mani Baskaran 《Indian journal of ophthalmology》2022,70(12):4218
Purpose:To compare outcomes of surgical management of uveitic glaucoma (UG) and steroid-induced glaucoma (SIG) in children in terms of intraocular pressure (IOP) control, visual acuity, and associations for failure.Methods:This was a retrospective case–control study of consecutive UG (cases) and non-uveitic SIG (controls) in children <18 years of age who underwent surgery between January 2005 and December 2017.Results:Primary trabeculectomy with mitomycin C (MMC) was performed in 12 cases (mean age: 9.2 ± 4.3 years) and 40 controls (mean age: 10.4 ± 3.7 years) (P = 0.33). Primary phaco-trabeculectomy with MMC was performed in 11 cases (mean age: 11.4 ± 4.7 years) and 16 controls (mean age: 10.4 ± 3.4 years) (P = 0.57). IOP control (P = 0.26), visual acuity (P = 0.97), number of glaucoma medications (P = 0.06), and survival rates (49% cases vs. 68% controls at 5 years; P = 0.22) were similar between the two groups following trabeculectomy. Survival rates in the phaco-trabeculectomy group at 5 years were 68% cases vs. 69% controls (P = 0.71). IOP was higher (P = 0.008) and visual acuity was worse (P = 0.02) in cases at the last visit. Associations for failure (univariate analysis) were younger age (OR: 6.29, 95% CL: 1.43, 27.67; P = 0.03) and male gender (OR: 4.79, 95% CL: 1.09, 20.97; P = 0.04). On multivariate analysis, younger age (OR: 11.985, 95% CL: 1.071, 134.153; P = 0.04) remained significant. Preoperative number of uveitic attacks was protective on univariate (OR: 0.75, 95% CL: 0.48, 1.15; P = 0.1) and multivariate analyses (OR: 0.49, 95% CL: 0.24, 0.09; P = 0.04).Conclusion:Outcomes of trabeculectomy between cases and controls were similar in our series. However, phaco-trabeculectomy in pediatric uveitic eye group fared worse than eyes with SIG. 相似文献
36.
Sushant Madaan Kowsigan Magesan Aditya Verma Jyotirmay Biswas 《Indian journal of ophthalmology》2022,70(2):435
Purpose:To describe the clinical profile, multimodal imaging, and treatment response in macular serpiginous choroiditis (MSC).Methods:Clinical records of 16 eyes (14 patients) with MSC presenting to a tertiary eye care institute between 2015 and 2019 were analyzed retrospectively.Results:Mean age of 14 patients presenting with MSC was 33 ± 13 yrs with 64% males and 36% females. Mean visual acuity of the eyes with MSC at presentation was 0.43 ± 0.46 (logMAR) improving to 0.16 ± 0.28 (logMAR) at final visit. Thirteen eyes (81.3%) had active lesion at presentation. Mantoux test was positive in seven patients (50%) and QuantiFERON TB gold test positive in 10 patients (71%). HRCT chest showed latent tuberculosis in seven patients (50%). All patients underwent multimodal imaging. All patients received oral steroids as treatment therapy; 11 patients also received immunosuppressives, nine patients received additional anti-tubercular therapy (ATT). Mean duration of follow-up for the patients was 18 ± 10 months. A total of eight (50%) eyes had recurrence of lesions after an average duration of 14 ± 14 (3-36) months and were restarted on the treatment as per the requirement. At final follow-up, all eyes showed a good response to treatment and had healed lesions. Comparing the final BCVA to the initial BCVA, 38% (n = 6) showed improvement, 56% (n = 9) remained stable, and 6% (n = 1) eyes worsened at the final follow-up.Conclusion:Clinical profile and presentation of MSC is similar to that of CSC, and combination treatment with intravenous methyl prednisolone (IVMP), steroids, immunosuppressives, and ATT can salvage vision. A high suspicion of associated tuberculosis in endemic regions should be kept in mind. 相似文献
37.
Debmalya Sanyal Mansij Biswas Nayan Chaudhari 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2021,15(1):13-19
Background and aimsEvaluation of long-term efficacy and safety of various anti-hyperglycaemic agents (AHA) for glycaemic control in NODAT, in stable kidney transplant recipients (KTRs) during 1-year outpatient follow-up.MethodsWe collected FPG, PPG, HbA1c, serum creatinine, eGFR, blood tacrolimus level, hypoglycaemia and body weight values from an existing database of KTRs diagnosed to have NODAT. Those newly initiated on AHA over 3 months post-transplant; received standard triple immunosuppressive therapy; and followed up for 1-year after referral, were included.ResultsIn ninety-five patients’ (Male = 65), mean decrease at 1-year from baseline in FPG (185.01 ± 62.11 mg/dL), PPG (293.21 ± 85.23 mg/dL) and HbA1c (8.48 ± 1.08%) was 67.09, 126.11 and 1.4 respectively (p < 0.0001). At 1-year, mean HbA1c was 7.08 ± 0.38%, ninety-one patients achieving HbA1c ≤ 7.5%. Fifty-two patients received oral combination therapy based on linagliptin/metformin/repaglinide/gliclazide, 19 received insulin-based regimen, and 24 received linagliptin monotharapey. Thirty patients reported hypoglycaemia (10 with gliclazide and 15 with insulin) and fifty patients gained body-weight at 1-year. Mean serum creatinine and eGFR significantly improved by 0.29 and 15.77 from baseline of 1.56 ± 0.62 mg/dL and 53.95 ± 16.10 mL/min/1.73 m2 respectively.ConclusionsSignificant proportion of NODAT patients achieved long-term glycemic control with improved renal function. Combination therapy was needed in most within 1-year. Linagliptin monotherapy was effective, without producing hypoglycaemia or weight gain. 相似文献
38.
39.
40.
Maria Bindu Bagh Ishita Guha Thakurta Mallika Biswas Prajna Behera Sasanka Chakrabarti 《Biogerontology》2011,12(2):119-131
A combination of antioxidants (N-acetyl cysteine, α-lipoic acid, and α-tocopherol) was selected for long term oral supplementation
study in rats for protective effects on age-related mitochondrial alterations in the brain. Four groups of rats were chosen:
young control (6–7 months); aged rats (22–24 months); aged rats (22–24 months) on daily antioxidant supplementation from 18 month
onwards and young rats (6–7 months) on daily antioxidant supplementation from 2 month onwards. The brain mitochondrial functional
parameters, status of antioxidant enzymes and accumulation of oxidative damage markers were measured in the four groups of
rats. A significant decrease in complex IV activity and a loss of transmembrane potential and phosphorylation capacity along
with an increased accumulation of oxidative damage markers and compromised antioxidant enzyme status were noticed in aged
rat brain mitochondria as compared to that in young controls, but in aged rats supplemented with oral antioxidants the mitochondrial
alterations were largely prevented. Antioxidant supplementation in young rats had no effect on mitochondrial parameters investigated
in this study. The results have implications in biochemical and functional deficits of brain during aging as well as in neurodegenerative
disorders. 相似文献