全文获取类型
收费全文 | 2674篇 |
免费 | 165篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 50篇 |
儿科学 | 103篇 |
妇产科学 | 72篇 |
基础医学 | 403篇 |
口腔科学 | 16篇 |
临床医学 | 201篇 |
内科学 | 442篇 |
皮肤病学 | 65篇 |
神经病学 | 93篇 |
特种医学 | 35篇 |
外科学 | 246篇 |
综合类 | 197篇 |
一般理论 | 4篇 |
预防医学 | 192篇 |
眼科学 | 350篇 |
药学 | 174篇 |
中国医学 | 14篇 |
肿瘤学 | 183篇 |
出版年
2023年 | 16篇 |
2022年 | 44篇 |
2021年 | 89篇 |
2020年 | 67篇 |
2019年 | 48篇 |
2018年 | 66篇 |
2017年 | 38篇 |
2016年 | 65篇 |
2015年 | 82篇 |
2014年 | 101篇 |
2013年 | 143篇 |
2012年 | 173篇 |
2011年 | 170篇 |
2010年 | 119篇 |
2009年 | 71篇 |
2008年 | 152篇 |
2007年 | 150篇 |
2006年 | 111篇 |
2005年 | 112篇 |
2004年 | 121篇 |
2003年 | 116篇 |
2002年 | 109篇 |
2001年 | 79篇 |
2000年 | 94篇 |
1999年 | 70篇 |
1998年 | 30篇 |
1997年 | 15篇 |
1996年 | 16篇 |
1995年 | 16篇 |
1994年 | 18篇 |
1993年 | 10篇 |
1992年 | 24篇 |
1991年 | 30篇 |
1990年 | 30篇 |
1989年 | 18篇 |
1988年 | 21篇 |
1987年 | 16篇 |
1986年 | 13篇 |
1985年 | 14篇 |
1984年 | 10篇 |
1981年 | 7篇 |
1978年 | 8篇 |
1977年 | 9篇 |
1976年 | 9篇 |
1975年 | 10篇 |
1973年 | 10篇 |
1972年 | 9篇 |
1970年 | 7篇 |
1968年 | 11篇 |
1967年 | 7篇 |
排序方式: 共有2840条查询结果,搜索用时 234 毫秒
121.
122.
Anshuman Elhence Manas Vaishnav Sagnik Biswas Ashish Chauhan Abhinav Anand Shalimar 《临床与转化肝病杂志(英文版)》2021,9(2):247-255
Within a year of its emergence, coronavirus disease-2019 (COVID-19) has evolved into a pandemic. What has emerged during the past 1 year is that, apart from its potentially fatal respiratory presentation from which the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) derives its name, it presents with a myriad of gastrointestinal (GI) and liver manifestations. Expression of the angiotensin-converting enzyme-2 (ACE-2) receptor throughout the GI tract and liver, which is the receptor for the SARS-CoV-2, may be responsible for the GI and liver manifestations. Besides acting directly via the ACE-2 receptor, the virus triggers a potent immune response, which might have a role in pathogenesis. The virus leads to derangement in liver function tests in close to 50% of the patients. The impact of these derangements in patients with a normal underlying liver seems to be innocuous. Severe clinical presentations include acute decompensation and acute-on-chronic liver failure in a patient with chronic liver disease, leading to high mortality. Evolving data suggests that, contrary to intuition, liver transplant recipients and patients with autoimmune liver disease on immunosuppression do not have increased mortality. The exact mechanism underlying why immunosuppressed patients fare well as compared to other patients remains to be deciphered. With newer variants of COVID-19, which can spread faster than the original strain, the data on hepatic manifestations needs to be updated to keep a step ahead of the virus. 相似文献
123.
Rajoo Thapa Debkrishna Mallick Biswajit Biswas 《International journal of infectious diseases》2010,14(3):e254-e256
India remains endemic for both vivax malaria and tuberculosis. In spite of the high burden of tuberculosis in the country, reports on congenital tuberculosis in the literature are limited. We report herein an unusual instance of co-occurrence of perinatal falciparum malaria and tuberculosis in a 34-day-old female newborn, who presented with symptoms of sepsis. The diagnosis was based on the demonstration of Plasmodium falciparum on peripheral blood smear and tubercle bacilli in gastric aspirate samples. The maternal history for falciparum malaria was positive during her eighth month of pregnancy and the father was an open case of sputum smear-positive pulmonary tuberculosis. She responded dramatically to combined antimalarial and antitubercular chemotherapy. A search for combined etiologies in presumed ‘sepsis’ in the newborn, guided by history, physical examination, and laboratory investigations, is warranted. 相似文献
124.
Falguni Nag Arghyaprasun Ghosh Projna Biswas Gobinda Chatterjee Saugato Biswas 《Indian journal of dermatology》2013,58(5):385-387
Large plaque parapsoriasis (LPP) is an idiopathic, chronic scaly dermatosis classified within parapsoriasis group of diseases, occurring commonly in middle aged patients of all races and geographic regions. LPP and its variants are closely related to the patch stage of mycosis fungoides. The two types of LPP mostly described are the poikilodermatous and retiform parapsoriasis. We are reporting an ichthyosiform LPP for its rarity. 相似文献
125.
Prabhakar A. Tembhurne Bimalendu Mondal Kunj B. Pathak Sanchay K. Biswas Aniket Sanyal Mahendra P. Yadav Santanu K. Bandyopadhyay Raj K. Singh 《Archives of virology》2010,155(1):89-95
Sequence analysis of segment 2 (seg-2) of three Indian bluetongue virus (BTV) isolates, Dehradun, Rahuri and Bangalore revealed
99% nucleotide identity amongst them and 96% with the reference BTV 23. Phylogenetic analysis grouped the isolates in ‘nucleotype
D’. The deduced amino acid (aa) sequence of the Bangalore isolate showed a high variability in a few places compared to other
isolates. B-cell epitope analyses predicted an epitope that is present exclusively in the Bangalore isolate. Two-way cross
serum neutralization confirmed that Bangalore isolate is antigenically different from the other two isolates. The results
of this study suggest that these three isolates are VP2 variants of BTV 23. This signifies that non-cross-neutralizing variants
of the same BTV serotype should be included in vaccine preparation. 相似文献
126.
Rajeev Rahi Manoj Biswas Rahul Khanna A. K. Khanna 《The Indian journal of surgery》2010,72(2):138-139
We report a rare case of extragonadal germ cell tumour in a 55-year-old man. He presented with a painless mass in right inguinal
region, a few days after hernioplasty for right direct inguinal hernia, which caused diagnostic difficulties and treatment
problems. 相似文献
127.
We present a follow-up of a cohort of three cases of Muckle-Wells syndrome (MWS). The aim of this report is to characterise the symptoms of this rare autosomal dominant condition with respect to the ENT practice. A retrospective analysis of the clinical features of MWS from our outpatient follow-up record of the three patients diagnosed with MWS. An extensive literature search was performed, using Medline through Pub Med (1950-2010), EMBASE (1980-2009) and Ovid (1958-2009). Retrospective case note study. In the present cohort, progressive sensorineural hearing loss was the main presentation and has been followed up over 10 years (median). The spectrum of head and neck presentation from the world literature was reviewed and includes hypothyroidism, amyloid goitre, cervical lymphadenopathy, and facial rash. This is the first documented report of the Otolaryngological features of the MWS in the English ENT literature. An awareness of this rare syndrome is essential in order to diagnose this uncommon syndrome and thus to plan for a long-term follow-up. 相似文献
128.
Metalloprotease activity in a small heat shock protein of the human malaria parasite Plasmodium vivax 下载免费PDF全文
The malaria parasite affects millions of people each year, lives and multiplies in two different hosts, and synthesizes a large number of proteases and heat shock proteins (HSPs) for its survival. We describe here the characterization of a metalloprotease activity which resides in the small HSP (PVHSP28) of the common but noncultivable human malaria parasite Plasmodium vivax. The protein is expressed by erythrocytic stages of the parasite. It is expressed as a approximately 55-kDa polypeptide which is then processed to the 28-kDa mature protein. The latter was found to be an active protease in gelatin zymography. This protease showed its optimal activity at 37 degrees C (pH 7.6). It also retained its proteolytic activity at higher temperatures of up to 55 degrees C. The enzyme belongs to the metalloprotease class, as its proteolytic activity was most effectively blocked by 1,10-phenanthroline and was restored to a maximal level by the addition of zinc metal ions. Inhibitors for the cysteine, serine, and aspartate classes of proteases were ineffective against this enzyme. A homology search indicates that PVHSP28 probably belongs to a new class of HSPs which possess the metalloprotease signature sequence. 相似文献
129.
Polymerase chain reaction for detection of Mycobacterium tuberculosis in epiretinal membrane in Eales' disease 总被引:13,自引:0,他引:13
Madhavan HN Therese KL Gunisha P Jayanthi U Biswas J 《Investigative ophthalmology & visual science》2000,41(3):822-825
PURPOSE: Tuberculous etiology has been suggested in Eales' disease. Because epiretinal membrane (ERM) is formed on the inner surface of the retina in Eales' disease, it could be the most appropriate intraocular specimen for investigation. Therefore, a nested polymerase chain reaction (nPCR), which detects MPB64 gene of Mycobacterium tuberculosis on the archival specimens of ERM of well-documented Eales' and non-Eales' patients, was applied and the results compared. METHODS: nPCR technique was standardized, and the sensitivity and specificity of the primers were determined. nPCR technique was applied to tissue sections obtained from formalin-fixed and paraffin-embedded tissues of ERM from 23 patients with Eales' disease and 27 noninfective and non-Eales' disease patients as controls. RESULTS: nPCR technique was specific for M. tuberculosis genome and sensitive enough to detect 0.25 fg (corresponding to the presence of a single bacillus). Eleven (47.8%) ERM of 23 Eales' disease and 3 (11.1%) of 27 controls were positive for M. tuberculosis genome. The difference between the two groups was statistically significant (P = 0.001), indicating association of this bacterium with Eales' disease. CONCLUSIONS: The demonstration of the presence of M. tuberculosis DNA by nPCR technique in significant number of ERM of Eales' disease compared with the controls further emphasizes the probable role of this bacterium in the pathogenesis of this enigmatic clinical condition. 相似文献
130.
PURPOSE: Although conjunctival rhinosporidiosis is endemic in India, associated scleral melting and staphyloma formation are quite rare. We report clinical features and management in three patients with this unusual presentation. METHODS: Retrospective review of case records of three patients with conjunctival rhinosporidiosis. RESULTS: Infection occurred in young, healthy adults and was localized to the forniceal conjunctiva in all patients. The affected conjunctiva had numerous grey-white spherules, but a polyp-like lesion was not present in any patient. Diagnosis was based on clinical features and examination of scrapings from the involved conjunctiva. Treatment was surgical, with excision of infected conjunctival tissues and staphyloma repair with homologous sclera or autogenous periosteum. Failure to recognize the conjunctival pathology in one patient resulted in recurrence of the staphyloma. CONCLUSION: Conjunctival rhinosporidiosis can be associated with scleral staphyloma in young, healthy, adults. Differentiating this entity from idiopathic scleral ectasia requires knowledge of the clinical features of conjunctival rhinosporidiosis and a high index of clinical suspicion. 相似文献