全文获取类型
收费全文 | 25443篇 |
免费 | 1960篇 |
国内免费 | 49篇 |
专业分类
耳鼻咽喉 | 289篇 |
儿科学 | 875篇 |
妇产科学 | 736篇 |
基础医学 | 3576篇 |
口腔科学 | 404篇 |
临床医学 | 2862篇 |
内科学 | 4600篇 |
皮肤病学 | 412篇 |
神经病学 | 2422篇 |
特种医学 | 612篇 |
外国民族医学 | 5篇 |
外科学 | 2913篇 |
综合类 | 289篇 |
一般理论 | 15篇 |
预防医学 | 3599篇 |
眼科学 | 365篇 |
药学 | 1672篇 |
中国医学 | 21篇 |
肿瘤学 | 1785篇 |
出版年
2023年 | 258篇 |
2022年 | 478篇 |
2021年 | 899篇 |
2020年 | 478篇 |
2019年 | 869篇 |
2018年 | 976篇 |
2017年 | 677篇 |
2016年 | 727篇 |
2015年 | 788篇 |
2014年 | 1088篇 |
2013年 | 1256篇 |
2012年 | 1923篇 |
2011年 | 1939篇 |
2010年 | 969篇 |
2009年 | 852篇 |
2008年 | 1390篇 |
2007年 | 1407篇 |
2006年 | 1260篇 |
2005年 | 1181篇 |
2004年 | 1090篇 |
2003年 | 865篇 |
2002年 | 830篇 |
2001年 | 305篇 |
2000年 | 321篇 |
1999年 | 239篇 |
1998年 | 241篇 |
1997年 | 210篇 |
1996年 | 200篇 |
1995年 | 224篇 |
1994年 | 130篇 |
1993年 | 124篇 |
1992年 | 227篇 |
1991年 | 231篇 |
1990年 | 186篇 |
1989年 | 135篇 |
1988年 | 153篇 |
1987年 | 152篇 |
1986年 | 137篇 |
1985年 | 144篇 |
1984年 | 141篇 |
1983年 | 112篇 |
1982年 | 102篇 |
1980年 | 96篇 |
1979年 | 133篇 |
1978年 | 96篇 |
1977年 | 90篇 |
1974年 | 88篇 |
1973年 | 90篇 |
1971年 | 92篇 |
1970年 | 98篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
Inclusion of satellites in an 18/21 translocation chromosome shown by ammonical-silver staining (sat-banding) in case of partial trisomy 18.
下载免费PDF全文
![点击此处可从《Journal of medical genetics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
R L Neu C C Ortega G A Barg W Pinto Jr L I Gardner W M Howell T E Denton 《Journal of medical genetics》1976,13(6):520-522
A male infant with a partial trisomy 18 and a 46,XY, --21, t(18;21)(18qter replaced by 18q12::21 p13 replaced by 21 qter) chromosome complement is described. The translocation chromosome is of special interest because it includes the satellites of chromosome 21. This was shown by differential satellite staining with the ammoniacal-silver technique. 相似文献
102.
Georg H. Eifert Stephanie E. Hodson Doreen R. Tracey L. Seville Kumar Gunawardane 《Journal of behavioral medicine》1996,19(4):385-399
Psychological features and complaints of persons presenting to medical settings with heart-focused anxiety and noncardiac chest pain are poorly understood. Comparing 20 healthy heart-anxious patients to cardiac and surgical inpatients and nonpatient controls, we found that healthy heart-anxious patients (a) were as afraid of chest pain and heart palpitations as inpatients with heart disease, (b) were as incapacitated by symptoms and using medical services as much as both inpatient groups; and (c) reported higher levels of cardiac disease conviction, heart awareness, and behaviors designed to protect their heart than surgical patients and nonpatients. Compared to all other groups, healthy heart-anxious patients reported more panic and other anxiety disorders, hypochondriacal beliefs, physical symptoms, obsessive-compulsive concerns, and negative affect. Following a hyperventilation test, heart-anxious patients also indicated more distressing symptoms and thoughts, and felt less safe and in control than surgical patients and nonpatients. Results support efforts for a timely recognition, diagnosis, and behavioral treatment of persons with heart-focused anxiety. 相似文献
103.
Many natural actions require the coordination of two different kinds of movements. How are targets chosen under these circumstances: do central commands instruct different movement systems in parallel, or does the execution of one movement activate a serial chain that automatically chooses targets for the other movement? We examined a natural eye tracking action that consists of orienting saccades and tracking smooth pursuit eye movements, and found strong physiological evidence for a serial strategy. Monkeys chose freely between two identical spots that appeared at different sites in the visual field and moved in orthogonal directions. If a saccade was evoked to one of the moving targets by microstimulation in either the frontal eye field (FEF) or the superior colliculus (SC), then the same target was automatically chosen for pursuit. Our results imply that the neural signals responsible for saccade execution can also act as an internal command of target choice for other movement systems. 相似文献
104.
Use of 125I-secretin to identify and characterize high-affinity secretin receptors on pancreatic acini 总被引:1,自引:0,他引:1
R T Jensen C G Charlton H Adachi S W Jones T L O'Donohue J D Gardner 《The American journal of physiology》1983,245(2):G186-G195
We prepared 125I-secretin and studied the kinetics, stoichiometry, and chemical specificity with which the labeled peptide binds to dispersed acini prepared from guinea pig pancreas. Iodinated secretin retained intrinsic biological activity in that it was as effective but 2.5-times less potent than native secretin in its ability to bind to pancreatic acini and to increase cellular cAMP. Scatchard analysis of binding of 125I-secretin indicated that each pancreatic acinar cell has approximately 93,000 binding sites, half of which are occupied by 11 nM iodinated secretin. Binding of 125I-secretin was rapid, reversible, saturable, specific, and temperature dependent. Binding of 125I-secretin was inhibited by secretin, vasoactive intestinal peptide, PHI, and Gila monster venom but not by glucagon, gastric inhibitory polypeptide, cholecystokinin, caerulein, gastrin, bovine pancreatic polypeptide, somatostatin, neurotensin, leucine-enkephalin, methionine-enkephalin, carbachol, bombesin, litorin, eledoisin, physalaemin, or substance P. With agonists (secretin, vasoactive intestinal peptide, PHI, or Gila monster venom), as well as antagonists (C-terminal fragments of secretin), there was a close correlation between their relative potencies for inhibiting binding of 125I-secretin and their relative potencies for increasing cAMP (agonists) or inhibiting the secretin-induced increase in cAMP (antagonists). For a given agonist, however, a 40-fold higher concentration was required for half-maximal inhibition of binding of 125I-secretin than was required to produce a half-maximal increase in cellular cAMP. Thus, maximal stimulation of cellular cAMP occurs when approximately one-third of the secretin receptors are occupied by an agonist. 相似文献
105.
Dunphy CH Galambos C Polski JM Evans HL Gardner LJ Grosso LE Montone KT 《Archives of pathology & laboratory medicine》2002,126(3):351-356
Posttransplant lymphoproliferative disorders (PTLDs) represent a morphologic, immunophenotypic, and genotypic spectrum of disease. Most recently, Knowles et al divided PTLDs into 3 distinct categories: (1) plasmacytic hyperplasia, (2) polymorphic B-cell hyperplasia and polymorphic B-cell lymphoma, and (3) immunoblastic lymphoma and multiple myeloma. Although one form of PTLD may progress to another form, only 1 previous case has been reported in which multiple myeloma developed 14 months after an original diagnosis of plasmacytic hyperplasia. The type of solid organ transplant was not specified in that case. We report a post--cardiac transplant plasmacytic hyperplasia developing 7 years posttransplant. Six years subsequent to the plasmacytic hyperplasia, the patient developed a posttransplant plasmacytic malignancy, supported by morphology, flow cytometric immunophenotyping, and genotypic studies. Since we have no data to support disseminated bony disease or an abnormal serum protein, we have not used the term "multiple myeloma" for this case. 相似文献
106.
Sebastian Gardner 《Medical history》1989,33(2):268-269
107.
D S Burke J F Brundage J R Herbold W Berner L I Gardner J D Gunzenhauser J Voskovitch R R Redfield 《The New England journal of medicine》1987,317(3):131-136
During the six months from October 1985 through March 1986, blood samples from 306,061 civilian applicants for military service from the United States were tested for antibody to the human immunodeficiency virus (HIV). Four hundred sixty subjects were positive for the antibody as determined by Western (immune) blot reactivity. The mean prevalence of HIV infection in this population of teenagers and young adults was thus 1.50 per 1000. According to multivariate analysis, the following demographic factors were found to be significant independent predictors of a positive HIV-antibody test: age (adjusted odds ratio = 1.10 per year), black race (adjusted odds ratio = 2.04), male sex (adjusted odds ratio = 1.84), residence in a densely populated county (adjusted odds ratio = 1.05 per 1000 per square mile), and residence in a metropolitan area with a high incidence of the acquired immunodeficiency syndrome (adjusted odds ratio = 1.53). Antibody-positive applicants were identified in 43 of the 50 states. Counties with high prevalence rates for HIV (greater than 5 per 1000) were located in New York State (four counties), New Jersey (three counties), California (two counties), Maryland (two counties), and Texas, Colorado, and Washington, D.C. 相似文献
108.
Paul Kruszka Tommy Hu Sungkook Hong Rebecca Signer Benjamin Cogné Betrand Isidor Sarah E. Mazzola Jacques C. Giltay Koen L. I. van Gassen Eleina M. England Lynn Pais Charlotte W. Ockeloen Pedro A. Sanchez‐Lara Esther Kinning Darius J. Adams Kayla Treat Wilfredo Torres‐Martinez Maria F. Bedeschi Maria Iascone Stephanie Blaney Oliver Bell Tiong Y. Tan Marie‐Ange Delrue Julie Jurgens Brenda J. Barry Elizabeth C. Engle Sarah K. Savage Nicole Fleischer Julian A. Martinez‐Agosto Kym Boycott Elaine H. Zackai Maximilian Muenke 《American journal of medical genetics. Part A》2019,179(10):2075-2082
Zinc finger protein 462 (ZNF462) is a relatively newly discovered vertebrate specific protein with known critical roles in embryonic development in animal models. Two case reports and a case series study have described the phenotype of 10 individuals with ZNF462 loss of function variants. Herein, we present 14 new individuals with loss of function variants to the previous studies to delineate the syndrome of loss of function in ZNF462. Collectively, these 24 individuals present with recurring phenotypes that define a multiple congenital anomaly syndrome. Most have some form of developmental delay (79%) and a minority has autism spectrum disorder (33%). Characteristic facial features include ptosis (83%), down slanting palpebral fissures (58%), exaggerated Cupid's bow/wide philtrum (54%), and arched eyebrows (50%). Metopic ridging or craniosynostosis was found in a third of study participants and feeding problems in half. Other phenotype characteristics include dysgenesis of the corpus callosum in 25% of individuals, hypotonia in half, and structural heart defects in 21%. Using facial analysis technology, a computer algorithm applying deep learning was able to accurately differentiate individuals with ZNF462 loss of function variants from individuals with Noonan syndrome and healthy controls. In summary, we describe a multiple congenital anomaly syndrome associated with haploinsufficiency of ZNF462 that has distinct clinical characteristics and facial features. 相似文献
109.
110.
Johnson JG Cohen P Kotler L Kasen S Brook JS 《Journal of consulting and clinical psychology》2002,70(5):1119-1128
Longitudinal data were used to investigate whether anxiety, depressive, disruptive, personality, or substance use disorders are associated with risk for the development of eating disorders during adolescence or early adulthood. Psychiatric disorders were assessed among 726 youths from a random community sample during adolescence and early adulthood. Depressive disorders during early adolescence were associated with elevated risk for the onset of eating disorders, dietary restriction, purging behavior, and recurrent weight fluctuations after preexisting eating problems and other psychiatric disorders were controlled statistically. Disruptive and personality disorders were independently associated with elevated risk for specific eating or weight problems. The present findings suggest that depressive disorders during early adolescence may contribute to the development of eating disorders during middle adolescence or early adulthood. 相似文献