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Christopher D Gardner James L Zehnder Alison J Rigby Joel R Nicholus John W Farquhar 《Blood coagulation & fibrinolysis》2007,18(8):787-793
Several case reports have implicated Ginkgo biloba in clinically adverse bleeding disorders. Ginkgo biloba has been reported to increase pain-free walking distance among patients with peripheral artery disease (PAD). Standard PAD therapy includes 325 mg/day aspirin. The objective of this study was to examine potential adverse effects of concomitant aspirin and Ginkgo biloba on platelet function. Ginkgo biloba (EGb 761, 300 mg/day) was compared with placebo for effects on measures of platelet aggregation among adults consuming 325 mg/day aspirin in a randomized, double-blind, placebo-controlled, parallel design trial of 4-week duration. Participants were adults, age 69 +/- 10 years, with PAD or risk factors for cardiovascular disease. Outcome measures included platelet function analysis (PFA-100 analyzer) using ADP as an agonist (n = 26 placebo; n = 29 ginkgo), and platelet aggregation using ADP, epinephrine, collagen and ristocetin as agonists (n = 21 placebo; n = 23 ginkgo). Participants kept daily logs of bleeding or bruising episodes. There were no clinically or statistically significant differences between treatment groups for any agonists, for either PFA-100 analysis or platelet aggregation. Reports of bleeding or bruising were infrequent and similar for both study groups. In conclusion, in older adults with PAD or cardiovascular disease risk, a relatively high dose of Ginkgo biloba combined with 325 mg/day daily aspirin did not have a clinically or statistically detectable impact on indices of coagulation examined over 4 weeks, compared with the effect of aspirin alone. No adverse bleeding events were observed, although the trial was limited to a small sample size. 相似文献
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Stephanie Atkinson 《Canadian Medical Association journal》2004,170(8):1208-1209
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Jutta Liebau Stephanie Heidrich Alfred Berger Mayer Tenenhaus Hans-Oliver Rennekampff 《European journal of plastic surgery》2007,29(5):235-242
Re-epithelialization of cutaneous wounds is a coordinated process of proliferation and migration of keratinocytes at the wound
edge. The study objective was to identify the differences in epidermal morphology, keratinocyte proliferation and matrix molecules
(laminin 1, laminin 5, type IV collagen) and their specific integrin (α3, α6) expression in biopsies of meshed split thickness
grafted and chronic wounds. The mean mitotic index of keratinocytes (ratio of cell cycle associated antigen Ki-67 expressing
keratinocytes to basal keratinocytes) was highest in chronic wounds (38.7%) compared to acute wounds (22.25%, range 5.7% to
54%). The mean thickness of the hyper-proliferative epithelium at the wound edge of chronic wounds was 0.69 mm compared to
0.15 mm at the wound margin of split thickness grafted wounds. Both chronic wounds and skin grafted wounds exhibited strong
laminin 5 immunoreactivity at the basal side of the epithelium, which extended under the most forward keratinocytes. Laminin
1 and type IV collagen immunoreactivity did not extend to the wound margin in either skin grafted or chronic wounds. In both
transplanted skin and chronic wounds, the integrin sub-units α3 and α6 exhibited a strong pericellular immunoreactivity on
the leading keratinocytes of the wound margin. Our data demonstrates that the proliferation of keratinocytes and the expression
of associated integrins are not impaired in chronic wounds.
Presented at the 33rd Congress of the Association of German Plastic Surgeons, Germany, 18–21 September, 2002. 相似文献
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Treatment of dyskeratosis congenita with Granulocyte Colony-Stimulating Factor and Erythropoietin 总被引:1,自引:0,他引:1
Blanche P. Alter Frank H. Gardner & Robert E. Hall 《British journal of haematology》1997,97(2):309-311
Aplastic anaemia is both frequent and difficult to manage in patients with dyskeratosis congenita (DC). We recently treated a 23-year-old male for a year with granulocyte colony-stimulating factor (G-CSF) and erythropoietin (Ep), with an excellent neutrophil response, and a transient effect on haemoglobin levels. G-CSF alone or combined with other cytokines may provide at least a partial effect in pancytopenic patients with DC. 相似文献
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