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651.
Corinne MP Buysse Lindy CAC Vermunt Hein Raat Jan A Hazelzet Wim CJ Hop Elisabeth MWJ Utens Koen FM Joosten 《Critical care (London, England)》2010,14(3):R124
Introduction
The purpose of this study was to evaluate associations between long-term physical and psychological outcome variables in patients who survived meningococcal septic shock (MSS) in childhood. 相似文献652.
Stegmaier J Kirchhoff C Kanz KG Mayer V Landes J Euler E Mutschler W Biberthaler P 《World journal of surgery》2006,30(12):2142-2151
Background Post-traumatic inflammation is connected to polymorphonuclear neutrophil (PMN)-dysfunction characterized by reduced nuclear
translocation of NF-κB during the post-traumatic period. However, the dynamic of NF-κB translocation in PMN of major trauma
patients remains unclear. Hence, the aim of this pilot study was to analyze NF-κB in PMN from multiply injured patients immediately
after trauma.
Patients and Methods Blood samples of major trauma patients (ISS > 16) were drawn on admission within 90 minutes after trauma and at 6, 12, 24,
48, and 72 hours after trauma. Neutrophilic NF-κB-translocation was analyzed by EMSA and quantified by densitometry as (arbitrary
units). In addition, PMN of healthy volunteers were analyzed either in their native state (–control) or after LPS stimulation
(+control).
Results Twelve patients (NISS: 34 ± 10 [mean ± SEM]) were enrolled. NF-κB translocation was significantly increased in trauma patients
on admission and after 6 hours. Interestingly, a second activity peak was present after 24 hours. In patients who later died,
NF-κB activity was significantly elevated initially, to be rapidly diminished after 6 hours, while it increased in the survivors
group. After 24 hours NF-κB activity increased significantly in the survivors group, to become reduced in both groups at a
later time.
Conclusions Within this pilot study, the dynamic of NF-κB translocation in PMN of multiply injured patients immmediately after trauma
was analyzed for the first time. Enabled by closely matched sequential blood sampling strictly standardized to the traumatic
event, an essential biphasic increase of neutrophilic signal transduction could be investigated in the very early post-traumatic
period, which preceded the downregulation of the innate immune system. 相似文献
653.
Hepatic malignancies: improved treatment with intraarterial Y-90 总被引:4,自引:0,他引:4
Herba MJ; Illescas FF; Thirlwell MP; Boos GJ; Rosenthall L; Atri M; Bret PM 《Radiology》1988,169(2):311-314
An improved treatment method for hepatic malignancies with yttrium-90 incorporated into the matrix of glass microspheres was evaluated prospectively. Fifteen patients with 12 metastatic colorectal cancers, one carcinoid, one islet cell tumor, and one hepatoma were treated with three dose levels: 5,000 cGy (5,000 rad), ten patients; 7,500 cGy (7,500 rad), three patients; and 10,000 cGy (10,000 rad), two patients. Mean follow-up was 7 months (range, 2-12 months). Stable disease in the liver was seen in ten patients, four of whom had concurrent progression of extrahepatic disease, which resulted in two deaths. Two additional deaths were not directly related to the malignant process. Progression of liver disease was found in five patients, with three deaths occurring at 7-8 months. No procedural, hematologic, or pulmonary complications occurred. Late gastroduodenal ulceration occurred at 6-8 weeks in three patients who had histories of chronic alcohol abuse. This method of therapy seems to be feasible and efficient. Caution is necessary with high doses or with patients with a history of or predisposition to gastroduodenal ulcers. 相似文献
654.
Six patients with calcified transitional cell carcinoma of the renal pelvis were encountered over a 10-year period, and the radiographic features in these cases are presented. Radiographically discernible calcification is one of the less common manifestations of this lesion, and the pattern of calcification may be variable. However, the combination of a coarse, punctate pattern with a mucosal lesion on excretory or retrograde urography should suggest the diagnosis and prompt further investigation. 相似文献
655.
656.
Neck neoplasms: MR imaging. Part II. Posttreatment evaluation 总被引:1,自引:0,他引:1
Glazer HS; Niemeyer JH; Balfe DM; Hayden RE; Emami B; Devineni VR; Levitt RG; Aronberg DJ; Ward MP; Lee JK 《Radiology》1986,160(2):349-354
Thirty-three patients who had undergone prior surgery and/or radiation therapy for malignant neoplasms of the neck were studied with magnetic resonance (MR) imaging. Twenty-seven of these patients were also evaluated with computed tomography (CT). Ten patients were healthy posttreatment volunteers, and 23 had documented tumor recurrence. MR images better demonstrated normal muscular landmarks, especially in patients with obliterated fat planes. Areas of posttreatment fibrosis or scarring were low in signal intensity with all MR pulse sequences. However, in three patients, high signal intensity from postradiation edema of the supraglottic area mimicked neoplasm. In patients with recurrent tumor, MR imaging was superior to CT in defining the relationship of tumor and muscle and in demonstrating vascular anatomy when no intravenous contrast material was given during the CT examination. In two patients tumor and fibrosis were separated on MR images because of signal intensity differences. CT scans, however, showed adjacent bone and cartilage anatomy better. Our data indicate that an MR examination may be helpful in patients in whom CT is indeterminate either because of anatomical distortion or suboptimal demonstration of vascular anatomy. 相似文献
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