全文获取类型
收费全文 | 899篇 |
免费 | 85篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 30篇 |
妇产科学 | 4篇 |
基础医学 | 187篇 |
口腔科学 | 2篇 |
临床医学 | 74篇 |
内科学 | 362篇 |
皮肤病学 | 4篇 |
神经病学 | 101篇 |
特种医学 | 45篇 |
外科学 | 77篇 |
综合类 | 1篇 |
预防医学 | 22篇 |
眼科学 | 4篇 |
药学 | 44篇 |
中国医学 | 1篇 |
肿瘤学 | 34篇 |
出版年
2024年 | 3篇 |
2023年 | 7篇 |
2022年 | 11篇 |
2021年 | 19篇 |
2020年 | 19篇 |
2019年 | 32篇 |
2018年 | 26篇 |
2017年 | 22篇 |
2016年 | 31篇 |
2015年 | 32篇 |
2014年 | 34篇 |
2013年 | 39篇 |
2012年 | 73篇 |
2011年 | 87篇 |
2010年 | 31篇 |
2009年 | 38篇 |
2008年 | 49篇 |
2007年 | 52篇 |
2006年 | 51篇 |
2005年 | 40篇 |
2004年 | 49篇 |
2003年 | 35篇 |
2002年 | 39篇 |
2001年 | 10篇 |
2000年 | 5篇 |
1999年 | 8篇 |
1998年 | 11篇 |
1997年 | 13篇 |
1996年 | 13篇 |
1995年 | 11篇 |
1994年 | 8篇 |
1993年 | 10篇 |
1992年 | 6篇 |
1991年 | 5篇 |
1990年 | 6篇 |
1989年 | 4篇 |
1988年 | 5篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1985年 | 3篇 |
1984年 | 8篇 |
1983年 | 2篇 |
1982年 | 6篇 |
1981年 | 5篇 |
1979年 | 7篇 |
1977年 | 2篇 |
1976年 | 4篇 |
1974年 | 4篇 |
1973年 | 2篇 |
1957年 | 1篇 |
排序方式: 共有995条查询结果,搜索用时 31 毫秒
41.
42.
Conscious and subliminal conflicts in normal subjects and patients with schizophrenia: the role of the anterior cingulate 总被引:8,自引:0,他引:8 下载免费PDF全文
Dehaene S Artiges E Naccache L Martelli C Viard A Schürhoff F Recasens C Martinot ML Leboyer M Martinot JL 《Proceedings of the National Academy of Sciences of the United States of America》2003,100(23):13722-13727
The human anterior cingulate cortex (ACC), which is active during conflict-monitoring tasks, is thought to participate with prefrontal cortices in a distributed network for conscious self-regulation. This hypothesis predicts that conflict-related ACC activation should occur only when the conflicting stimuli are consciously perceived. To dissociate conflict from consciousness, we measured the behavioral and brain imaging correlates of a motor conflict induced by task-irrelevant subliminal or conscious primes. The same task was studied in normal subjects and in patients with schizophrenia in whom the ACC and prefrontal cortex are thought to be dysfunctional. Conscious, but not subliminal, conflict affected anterior cingulate activity in normal subjects. Furthermore, patients with schizophrenia, who exhibited a hypoactivation of the ACC and other frontal, temporal, hippocampal, and striatal sites, showed impaired conscious priming but normal subliminal priming. Those findings suggest that subliminal conflicts are resolved without ACC contribution and that the ACC participates in a distributed conscious control network that is altered in schizophrenia. 相似文献
43.
Siproudhis L Eléouet M Rousselle A El Alaoui M Ropert A Bretagne JF 《Diseases of the colon and rectum》2008,51(9):1356-1360
PURPOSE Rectal prolapse is frequently associated with fecal incontinence; however, the relationship is questionable. The study was
designed to evaluate fecal incontinence in a large consecutive series of patients who suffered from rectal prolapse, focusing
on both past history, anal physiology, and imaging.
METHODS Eighty-eight consecutive patients who suffered from an overt rectal prolapse (72 women, 16 men; mean age, 51.1 ± 19.5 years)
as a main symptom were analyzed; 48 patients also experienced fecal incontinence compared with 40 without incontinence. Logistic
regression analyses were performed.
RESULTS The two groups of patients did not differ with respect to parity, weekly stool frequency, main duration of symptoms before
referral, occurrence of dyschezia, and digital help to defecate. Patients with prolapse who were older than 45 years (odds
ratio (OR), 4.51 (1.49–13.62); P = 0.007) and those with a past history of hemorrhoidectomy (OR, 9.05 (1.68–48.8); P = 0.01) were significantly more incontinent. Incontinent group showed frequent internal anal sphincter defect compared with
the continent group (60 vs. 6.2 percent; P = 0.0018).
CONCLUSIONS In patients with overt rectal prolapse, the occurrence of fecal incontinence needs special consideration for age and previous
hemorrhoid surgery as causative factors. Anal weakness and sphincter defects are frequently observed. 相似文献
44.
45.
46.
47.
Véronique Ezratty Ga?lle Guillossou Catherine Neukirch Monique Dehoux Serge Koscielny Marcel Bonay Pierre-André Cabanes Jonathan M. Samet Patrick Mure Luc Ropert Sandra Tokarek Jacques Lambrozo Michel Aubier 《Environmental health perspectives》2014,122(8):850-855
Background: Nitrogen dioxide (NO2), a ubiquitous atmospheric pollutant, may enhance the asthmatic response to allergens through eosinophilic activation in the airways. However, the effect of NO2 on inflammation without allergen exposure is poorly studied.Objectives: We investigated whether repeated peaks of NO2, at various realistic concentrations, induce changes in airway inflammation in asthmatics.Methods: Nineteen nonsmokers with asthma were exposed at rest in a double-blind, crossover study, in randomized order, to 200 ppb NO2, 600 ppb NO2, or clean air once for 30 min on day 1 and twice for 30 min on day 2. The three series of exposures were separated by 2 weeks. The inflammatory response in sputum was measured 6 hr (day 1), 32 hr (day 2), and 48 hr (day 3) after the first exposure, and compared with baseline values measured twice 10–30 days before the first exposure.Results: Compared with baseline measurements, the percentage of eosinophils in sputum increased by 57% after exposure to 600 ppb NO2 (p = 0.003) but did not change significantly after exposure to 200 ppb. The slope of the association between the percentage of eosinophils and NO2 exposure level was significant (p = 0.04). Eosinophil cationic protein in sputum was highly correlated with eosinophil count and increased significantly after exposure to 600 ppb NO2 (p = 0.001). Lung function, which was assessed daily, was not affected by NO2 exposure.Conclusions: We observed that repeated peak exposures of NO2 performed without allergen exposure were associated with airway eosinophilic inflammation in asthmatics in a dose-related manner.Citation: Ezratty V, Guillossou G, Neukirch C, Dehoux M, Koscielny S, Bonay M, Cabanes PA, Samet JM, Mure P, Ropert L, Tokarek S, Lambrozo J, Aubier M. 2014. Repeated nitrogen dioxide exposures and eosinophilic airway inflammation in asthmatics: a randomized crossover study. Environ Health Perspect 122:850–855; http://dx.doi.org/10.1289/ehp.1307240 相似文献
48.
Diane Paris MD David Rousset MD Fabrice Bonneville MD PhD Nelly Fabre MD Stanislas Faguer MD PhD Françoise Huguet-Rigal MD Claire Larcher MD Charlotte Martin MD Diane Osinski MD François Gaussiat MD Louis Delamarre MD David Brauge MD Olivier Fourcade MD PhD Thomas Geeraerts MD PhD Ségolène Mrozek MD PhD 《Headache》2020,60(10):2583-2588
49.
Thomas Ried Regina Knutzen Rüdiger Steinbeck Harald Blegen Evelin Schrck Kerstin Heselmeyer Stanislas du Manoir Gert Auer 《Genes, chromosomes & cancer》1996,15(4):234-245
Comparative genomic hybridization was used to screen the DNA extracted from histologically defined tissue sections from consecutive stages of colorectal carcinogenesis for chromosomal aberrations. No aberrations were detected in normal epithelium (n = 14). Gain of chromosome 7 occurred as a single event in low-grade adenomas (n = 14). In high-grade adenomas (n = 12), an overrepresentation of chromosomes 7 and 20 was present in 30% of the cases analyzed. The transition to colon carcinomas (n = 16) was characterized by the emergence of multiple chromosomal aberrations. Chromosomes 1, 13, and 20 and chromosome arms 7p and 8q were frequently gained, whereas chromosome 4 and chromosome arms 8p and 18q were recurrently underrepresented. The same tissue sections that were used for CGH were analyzed by means of DNA-ploidy measurements and immunohistochemical staining to quantify proliferative activity and p21/WAF-I and TP53 expression. We observed that crude aneuploidy and increased proliferative activity are early events in colorectal carcinogenesis, followed by TP53 overexpression and the acquisition of recurrent chromosomal gains and losses during the progression from high-grade adenomas to invasive carcinomas. Genes Chromosom Cancer (1996). © 1996 Wiley-Liss, Inc. 相似文献
50.
Tanguy Madec Stanislas Lagarde Aileen McGonigal Marie Arthuis Christian-Georges Benar Fabrice Bartolomei 《Epilepsia》2020,61(8):e101-e106
Psychogenic nonepileptic seizures (PNES) are paroxysmal clinical events that are often misdiagnosed as epileptic seizures, but which are not associated with electrographic discharge. Brain connectivity changes occurring during PNES are not known. We studied functional connectivity (Fc) in two patients with drug-resistant epilepsy, explored by stereotactic electroencephalography (EEG), in whom we recorded both epileptic seizures (ES) and PNES. Functional connectivity using pair-wise nonlinear correlation was computed between signals from seven brain areas: amygdala, hippocampus, lateral temporal cortex, anterior insula, orbitofrontal cortex, prefrontal cortex, and lateral parietal cortex. We assessed changes in global Fc during PNES in comparison with a background period. During PNES, a global decrease of Fc occurred between the different brain regions studied, compared with the interictal period. In both patients, decreased Fc was prominent in connections involving the anterior insula and parietal cortex. In conclusion, some PNES are associated with ictal functional disconnection between brain areas, particularly involving the parietal cortices and the anterior insula. 相似文献