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排序方式: 共有4964条查询结果,搜索用时 31 毫秒
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Trukeschitz Birgit Hajji Assma Litschauer Judith Malley Juliette Schoch Adiam Rand Stacey Linnosmaa Ismo Forder Julien 《Quality of life research》2021,30(3):905-920
Quality of Life Research - The Adult Social Care Outcomes Toolkit for Carers (ASCOT-Carer), developed in England, measures the effects of long-term care (LTC) services and carer support on informal... 相似文献
53.
Pharmacokinetics,cerebrospinal fluid penetration,and metabolism of piroxantrone in the Rhesus monkey
Stacey L. Berg Frank M. Balis Karen S. Godwin David G. Poplack 《Investigational new drugs》1993,11(4):255-261
Summary Piroxantrone is an anthrapyrazole derivative with broad anti-tumor activityin vitro and less cardiac toxicity than the anthracyclines. The metabolic pathways and central nervous system penetration of piroxantrone have not been determined. In this study we examined the pharmacokinetic behavior of piroxantrone in plasma and cerebrospinal fluid in a non-human primate model. In addition, a urinary metabolite of piroxantrone was isolated and its cytotoxicity evaluatedin vitro.
The disappearance of piroxantrone from plasma after an intravenous dose of 150 mg/m2 given over 60 minutes was biexponential with mean t1/2 alpha of 1.0 minutes and a mean t1/2 beta of 180 minutes. The mean area under the curve was 220 M·min and the clearance was 1420 ml/min/m2. Piroxantrone was not detectable in the cerebrospinal fluid.Piroxantrone and three other compounds not present in pre-treatment samples were detected in urine. The major urinary metabolite was isolated. Its cytotoxicity against MOLT-4 cellsin vitro was at least one log less than that of piroxantrone. In addition, one of the other compounds detected in urine was determined to be a glucuronide conjugation product of the major metabolite.The results of this study may be useful in the interpretation of the activity and toxicity of piroxantrone in clinical trials. 相似文献
54.
Effect of exercise on calf muscle pump function in patients with chronic venous disease 总被引:8,自引:0,他引:8
BACKGROUND: Musculoskeletal dysfunction may be associated with poor calf muscle pump function in patients with chronic venous ulceration. The aim of this study was to evaluate the effects of physical exercise on calf muscle pump function. METHODS: Twenty patients were recruited into a 6-week intensive exercise programme. Calf muscle function and calf muscle pump function were assessed using an isokinetic device and air plethysmography respectively, before and after the exercise programme. RESULTS: There was significant improvement in calf muscle pump function, measured as increased ejection fraction and decreased residual fraction (P < 0.05); however, venous reflux was not altered (P > 0.05). Calf muscle strength and endurance parameters all increased, but not significantly (P > 0.05). CONCLUSION: Poor calf muscle pump function in patients with chronic venous ulceration can be improved by physical exercise. 相似文献
55.
Waller SA Armstrong KJ McGrath AM Sullivan CL 《Journal of autism and developmental disorders》1999,29(6):485-490
This review summarizes subject selection and diagnostic procedures documented in the Journal of Autism and Developmental Disorders. One hundred forty-two empirical articles published between February 1993 and April 1997 were examined. Reviewers independently evaluated articles using a coding instrument developed by the authors. Results indicated that a majority of researchers reported the use of one or more standard diagnostic criteria in classifying their subjects. However, numerous studies did not report the methods by which the diagnostic criteria were quantified or applied. Additionally, there was a lack of clear specification of inclusion and exclusion criteria for comorbid disorders. Improving the documentation of diagnostic practices in research on autism will benefit researchers and practitioners. 相似文献
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Mills SE 《Endocrine pathology》1996,7(4):329-343
Virtually every variant of neuroendocrine neoplasia can occur, at least rarely, in the head and neck region. This review focuses
on the terminology surrounding neuroendocrine carcinomas of the larynx and their distinction from morphologically similar
but biologically distinctive neoplasmas. It is suggested that rare typical laryngeal carcinoids be labeled as such. There
is little evidence that these lesions are part of a morphologic continuum. In contrast, more common “carcinoid-like” carcinomas,
previously referred to as “atypical carcinoids” are more appropriately labeled as “moderately differentiated neuroendocrine
carcinomas”. These neoplasms should, in turn, be distinguished from “small cell neuroendocrine carcinomas,” although these
latter two neoplasms do represent a morphologic and behavioral spectrum. Light microscopic and immunohistochemical features
distinguishing neuroendocrine carcinomas of the larynx from paraganglioma, metastatic medullary carcinoma, malignant melanoma,
and basaloid squamous cell carcinoma are presented. The second portion of this review outlines the clinicopathologic features
of two head and neck neoplasms exhibiting varying degrees of neuroendocrine differentiation. Olfactory neuroblastomas have
well-developed neuroendocrine differentiation, almost invariably arise from the olfactory mucosa, typically exhibit low-grade
cytologic features, and may have protracted clinical course with an approximately 50% overall 5-yr survival. In contrast,
sinonasal undifferentiated carcinoma is a microscopically high-grade neoplasm with minimal, abortive neuroendocrine features,
a highly aggressive clinical course, and virtually 100% mortality. They can arise throughout the sinonasal region.
Presented at the Endocrine Pathology Society—USCAP Meeting, Washington, DC, March 23, 1996. 相似文献
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