全文获取类型
收费全文 | 1386358篇 |
免费 | 106765篇 |
国内免费 | 7421篇 |
专业分类
耳鼻咽喉 | 17322篇 |
儿科学 | 44095篇 |
妇产科学 | 36980篇 |
基础医学 | 204542篇 |
口腔科学 | 36942篇 |
临床医学 | 136145篇 |
内科学 | 266219篇 |
皮肤病学 | 27075篇 |
神经病学 | 114665篇 |
特种医学 | 50576篇 |
外国民族医学 | 403篇 |
外科学 | 189878篇 |
综合类 | 36376篇 |
现状与发展 | 8篇 |
一般理论 | 462篇 |
预防医学 | 117688篇 |
眼科学 | 30481篇 |
药学 | 104187篇 |
49篇 | |
中国医学 | 5813篇 |
肿瘤学 | 80638篇 |
出版年
2021年 | 13715篇 |
2019年 | 13385篇 |
2018年 | 18197篇 |
2017年 | 13896篇 |
2016年 | 14956篇 |
2015年 | 17689篇 |
2014年 | 23922篇 |
2013年 | 34826篇 |
2012年 | 48659篇 |
2011年 | 51425篇 |
2010年 | 29991篇 |
2009年 | 27293篇 |
2008年 | 45751篇 |
2007年 | 47954篇 |
2006年 | 47878篇 |
2005年 | 46064篇 |
2004年 | 43328篇 |
2003年 | 41131篇 |
2002年 | 39730篇 |
2001年 | 61927篇 |
2000年 | 63616篇 |
1999年 | 53347篇 |
1998年 | 15191篇 |
1997年 | 13936篇 |
1996年 | 13640篇 |
1995年 | 12897篇 |
1994年 | 11983篇 |
1993年 | 11172篇 |
1992年 | 41862篇 |
1991年 | 40984篇 |
1990年 | 39636篇 |
1989年 | 37498篇 |
1988年 | 34710篇 |
1987年 | 33802篇 |
1986年 | 32230篇 |
1985年 | 30709篇 |
1984年 | 23078篇 |
1983年 | 19632篇 |
1982年 | 11771篇 |
1979年 | 20825篇 |
1978年 | 14825篇 |
1977年 | 12067篇 |
1976年 | 11880篇 |
1975年 | 12113篇 |
1974年 | 14807篇 |
1973年 | 14482篇 |
1972年 | 13359篇 |
1971年 | 12425篇 |
1970年 | 11492篇 |
1969年 | 10418篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
102.
【目的】探讨中药淫羊藿、巴戟天提取物(中药注射液喘可治的组成)对恒河猴单核衍生的巨噬细胞在未极化(M0)、M1极化条件下基因表达的影响,分析其可能的免疫调节的作用机制。【方法】采用密度梯度离心法分离中国恒河猴外周血单个核细胞(PBMCs),采用贴壁法纯化出单核细胞,并以粒细胞巨噬细胞集落刺激因子(GM-CSF)刺激5 d以使单核细胞分化成巨噬细胞;然后不加入极化因子(M0)或以干扰素γ(IFN-γ,继续培养2 d)诱导巨噬细胞极化为M1表型,同时分别加入淫羊藿、巴戟天提取物进行干预;然后提取m RNA并逆转录后,采用实时荧光定量PCR检测CCR5、CD4、CTLA-4、Fox P3、IDO、IL-10、TGF-β等基因表达量。【结果】与空白对照组比较,加入巴戟天提取物培养的M0巨噬细胞基因表达上调不明显;经淫羊藿提取物培养的M0巨噬细胞,CCR5基因表达量上调4.21倍,TGF-β上调7.66倍,Fox P3、IL-10轻度上调,而CD4、CTLA-4、IDO等基因表达改变倍数无明显变化。经巴戟天提取物刺激的M1型巨噬细胞,CTLA-4基因表达量上调3.22倍,Fox P3上调3.69倍,CCR5、CD4、IL-10、IDO基因改变倍数均无明显变化,TGF-β未测出;而由淫羊藿提取物刺激的M1型巨噬细胞,IL-10的表达量上调11.83倍,Fox P3上调4.55倍,IDO、CCR5、CD4、CTLA-4基因改变倍数无明显变化,TGF-β未测出。【结论】巴戟天和淫羊藿提取物培养能够上调M1型巨噬细胞IL-10、Fox P3、CTLA-4等抑炎基因表达,淫羊藿提取物能够上调M0巨噬细胞CCR5和TGF-β等基因表达,促进病原体清除和组织修复,从而发挥多效免疫调节作用。 相似文献
103.
104.
105.
Eric S. Zhou Larissa Nekhlyudov Sharon L. Bober 《Translational andrology and urology》2015,4(2):218-231
There is a large and growing population of long-term cancer survivors. Primary care physicians (PCPs) are playing an increasingly greater role in the care of these patients across the continuum of cancer survivorship. In this role, PCPs are faced with the responsibility of managing a range of medical and psychosocial late effects of cancer treatment. In particular, the sexual side effects of treatment which are common and have significant impact on quality of life for the cancer survivor, often go unaddressed. This is an area of clinical care and research that has received increasing attention, highlighted by the presentation of this special issue on Cancer and Sexual Health. The aims of this review are 3-fold. First, we seek to overview common presentations of sexual dysfunction related to major cancer diagnoses in order to give the PCP a sense of the medical issues that the survivor may present with. Barriers to communication about sexual health issues between patient/PCPs in order are also described in order to emphasize the importance of PCPs initiating this important conversation. Next, we provide strategies and resources to help guide the PCP in the management of sexual dysfunction in cancer survivors. Finally, we discuss case examples of survivorship sexual health issues and highlight the role that a PCP can play in each of these case examples. 相似文献
106.
107.
108.
F. Giovanardi F. Nudo Q. Lai M. Garofalo A. Consolo E. Choppin De Janvry G.A. Arroyo Murillo P. Ursi D. Stabile F. Melandro P.B. Berloco R. Pretagostini L. Poli 《Transplantation proceedings》2019,51(1):128-131
Background
Arterial vascular anomalies in patients undergoing kidney transplantation (KT) are correlated with a higher incidence of early surgical complications, potentially causing graft loss. Arterial reconstruction allows patients to overcome these surgical challenges, thus minimizing the risk of poor outcomes. The aim of the present study is to retrospectively investigate the safety and effectiveness of the multiple arterial reconstruction technique with a Teflon patch in case of an unavailable aortic patch: to do so, surgical complications, graft function, and patient survival were evaluated.Methods
During the period January 2009 to August 2016, 202 adult deceased-donor KTs were performed at our center. Group A (n = 27; reconstruction of multiple arteries) and Group B (n = 175; control group) were compared.Results
No differences were observed between the 2 groups in terms of early postoperative course, with no vascular complication observed in Group A. No vascular patch infections were reported, nor longer cold ischemia time rates. Similarly, long-term survival rates were similar between the 2 groups.Conclusions
The Teflon-patch arterial reconstruction technique appears to be safe and effective, with an acceptable balance of benefits and potential risks of using a prosthetic material. Studies based on larger series are needed to further validate this approach. 相似文献109.
To evaluate the anthropometric indexes in subjects with varicocele compared to controls and the incidence of varicocele in different body mass index (BMI) groups for the purpose of exploring the association between varicocele and anthropometric indexes. A comprehensive literature search was conducted by using PubMed, MEDLINE, EMBASE databases and Cochrane Library up to February 2019. A systematic review and meta‐analysis was conducted by STATA, and Newcastle–Ottawa Scale was utilised for assessing risk of bias. Ultimately, 13 articles containing seven case–control studies and six cross‐sectional studies with 1,385,630 subjects were involved in our study. Pooled results demonstrated that varicocele patients had a lower BMI (WMD = ?0.77, 95% CI = ?1.03 to ?0.51) and a higher height than nonvaricocele participants, especially in grade 3 varicocele patients. Subgroup analyses showed that normal BMI individuals had a higher risk of varicocele than obese or overweight individuals and a lower risk than underweight individuals. In conclusion, this study indicates that varicocele patients have a lower BMI and a higher height than nonvaricocele participants. Moreover, men with excess bodyweight have a lower incidence of varicocele compared to normal weight or underweight people. That is to say, high BMI and adiposity protect against varicocele and high BMI is associated with a decreased risk of varicocele. 相似文献
110.