Effects of aging on beta-carotene and vitamin A status

Symposium paper: Aging and Nutrition. Presented on October 5, 1990 during the 20th Annual Meeting of AGE in New York City.     

Antiplatelet agents: current drugs and future trends

Antiplatelet drugs in clinical use are discussed in terms of their mechanisms of action and the relevancy of that to the physiology of platelets and the pathophysiology of arterial thrombosis. Current clinical usage is outlined in detail for each drug. Experimental antiplatelet drugs also are discussed.     

Lunamarin C,a new terpenoid coumarin from Clausena heptaphylla

The petroleum ether extract of the leaves of Clausena heptaphylla afforded a new coumarin, lunamarin C (1). Its structure was determined by extensive analysis of spectral data, including 2D NMR and by comparison with structurally related compounds, lunamarins A (2) and B (3).     

The Japanese Orthopedic Association Back Pain Evaluation Questionnaire (JOABPEQ) for low back disorders: a validation study from Iran

BackgroundLumbar disc hernia (LDH) and lumbar spinal stenosis (LSS) are the most common diagnoses of low back and leg pain symptoms. The Japanese Orthopedic Association Back Pain Evaluation Questionnaire (JOABPEQ) is a measure of health-related quality of life in these patients. This study aimed to cross-culturally translate and validate the JOABPEQ in Iran.MethodsThis was a prospective clinical validation study. The translation and cross-cultural adaptation of the original questionnaire was performed in accordance with published guidelines. A total of 103 patients with LDH or LSS were asked to respond to the questionnaire at two points in time: pre- and postoperative assessments (6 months follow-up). To test reliability, the internal consistency was assessed by Cronbach's alpha coefficient, and validity was assessed using convergent validity. Responsiveness to change was also assessed comparing patients' pre- and postoperative scores.ResultsThe Cronbach's alpha coefficients for the JOA-BPEQ at pre- and postoperative assessments ranged from 0.71 to 0.81, indicating a good internal consistency for the questionnaire. In addition, the correlation of each item with its hypothesized subscale of the JOABPEQ showed satisfactory results, suggesting that the items had a substantial association with the subscale representing the concept. Further analysis also indicated that the questionnaire was responsive to change (P < 0.0001).ConclusionsIn general, the Iranian version of JOABPEQ performed well, and the findings suggest that it is a reliable and valid measure of back pain evaluation among LDH and LCS patients.     

Parkinson’s disease and risk of hip fracture: systematic review and meta-analysis

The relationship between Parkinson’s disease (PD) and risk of hip fracture yielded inconsistent results. Therefore, we conducted the present systematic review and meta-analysis of published observational studies to assess the association between PD and risk of hip fracture. PubMed, ISI, EMBASE, and Cochrane databases were searched systematically to identify studies assessing the relationship between PD and the risk of hip fracture up to July 01, 2017. In addition, to find related articles, the reference section of retrieved articles was checked. Random-effects model was used for calculation of pooled hazard ratio (HR) and 95% confidence intervals (CI). Thirteen independent studies containing 564,947 participants were included in the meta-analysis. The overall results of included studies showed PD to be associated with the risk of hip fracture (HR_overall?=?3.13, 95% CI 2.53–3.87) in women 3.11 (2.51–3.86) and men 2.60 (2.19–3.09). Our meta-analysis showed the direct association between PD and the risk of hip fracture in both men and women. However, due to the limitations of this study, further well-designed studies are required to confirm our findings.     

The concept of protective stent placement after successful recanalization of chronic total coronary occlusions: a matched pair analysis in 100 patients

OBJECTIVE: Interim results of successful balloon angioplasty for total coronary occlusions (TCO) are disappointing due to the high rate of restenosis and reocclusion. Adjunctive stenting has been suggested to improve patency rate after recanalization of total coronary occlusions (TCO); however, this concept of protective stenting has not been substantiated in a case control study. METHODS: To test the efficacy of protective stenting of TCO, 100 patients were subjected to a matched pair analysis (block design) comparing conventional PTCA with protective stenting (Palmaz-Schatz stents) after successful recanalization of TCO followed by a standard antithrombotic regimen. Matching parameters included age (+/- 3.5 years), sex, cardiovascular risk factor, and lesion anatomy. Coronary angiography and QCA were performed before pair assignment, after the intervention, and at a mean follow-up of 5 +/- 1.5 months. RESULTS: There were no deaths or myocardial infarctions related to the intervention in the entire study cohort; bleeding at the puncture site was observed in two patients in both groups. Binary reocclusion and restenosis (> or = 50%) rates were observed in 8% and 0% in stented patients versus 30% and 22% in the group with no protective stenting, respectively (p < 0.01). Target lesion reintervention was necessary in 8% after protective stenting as compared to 58% after PTCA alone (p < 0.001). At 6 months follow-up, 62% of stented patients were free of any symptoms versus 23% with PTCA (p < 0.01). CONCLUSIONS: Protective stenting improves the immediate and follow-up angiographic and clinical results of PTCA in chronic total coronary occlusions. Stenting of successfully recanalized total coronary occlusions should be a routine procedure.     

Improved exercise performance and quality of life after percutaneous pulmonary valve implantation

Objective

Percutaneous pulmonary valve implantation (PPVI) has emerged as a new approach to treat patients with dysfunctional pulmonary valve conduits. Short- and midterm results have outlined hemodynamic improvements and increase in exercise performance. However, there is a lack of knowledge about quality of life at short term follow-up.

Patients and methods

From July 2007 to March 2013, we investigated 59 patients (17 female; median age 22.8 years) undergoing PPVI in our institution. 46 had predominant pulmonary stenosis (PS) and 13 had predominant pulmonary regurgitation (PR). They answered the quality of life questionnaire (SF-36) and underwent a cardiopulmonary exercise test and Cardiovascular Magnetic Resonance before and 6 months after PPVI.

Results

Peak oxygen uptake improved significantly from 27.2 (18.9; 34.0) ml/min/kg to 29.2 (22.4; 35.3) ml/min/kg (p < .0001), and from 69.6 (55.9; 83.6) %predicted to 76.3 (67.9; 92.7) %predicted, respectively. Improvements were seen in both, the PS (71.9 to 78.3 %predicted; p < .0001) and PR (62.7 to 73.0 %predicted; p < .0001) group.Self-estimated quality of life was good already before PPVI but increased in almost all domains 6 months after PPVI in PS and PR group. Significant improvements developed in “physical function”, “general health perception” and “health transition” in both groups, and “physical role functioning”, “vitality” and “mental health” only in the PS group.

Conclusions

In patients with dysfunctional pulmonary valve conduits exercise performance and quality of life improve substantially 6 months after successful percutaneous pulmonary valve implantation.