BCG skin reaction in Mantoux-negative healthy children

Background  

Tuberculosis poses a great challenge, especially in children. The response of BCG Test may be different in previously vaccinated children and needs to be considered before interpreting positivity for TB. This study has been carried out to determine the pattern of BCG reaction comparing previously vaccinated with non-vaccinated children.     

Rosai-Dorfman disease: unusual cause of diffuse and massive retroperitoneal lymphadenopathy

Rosai-Dorfman disease (RDD), originally described as sinus histiocytosis with massive lymphadenopathy, is a rare histiocytic proliferative disorder with a distinctive microscopic appearance. Patients usually present with massive cervical lymphadenopathy. However other nodal sites (mediastinal and inguinal) are also frequently involved. The retro-peritoneum is an infrequent site of involvement. This uncommon entity should also be included in the list of differential diagnoses of diffuse and massive lymphadenopathy, which includes includes infectious/granulomatous conditions, lymphomatous and metastatic disease.     

Torsion of a wandering spleen: acute abdominal presentation

Torsion of a wandering spleen is a rare but fulminant condition and is part of the differential diagnosis in patients presenting with acute abdominal pain. It results due to absence or laxity of the various ligaments supporting the spleen. Patients may be asymptomatic or may present with acute abdominal pain. It may occur in people of all ages, with a predilection for male patients under 10 years of age and for female patients in older age groups, being most common in multiparous women. Early intervention is necessary to reduce the risk of splenic infarction and other complications. An awareness of the condition together with use of appropriate medical imaging can lead to the correct diagnosis.     

Efficacy and safety of brimonidine, dorzolamide and latanoprost as adjunctive therapy in primary open angle glaucoma

A double-blind, randomised, controlled trial was carried out to evaluate the efficacy and safety of brimonidine, dorzolamide and latanoprost as an adjunctive therapy in patients with primary open angle glaucoma (POAG). A total of 200 males and 72 females with POAG uncontrolled with previous glaucoma therapy were randomly allocated to receive topical brimonidine 0.2% b.d. (n = 90), topical dorzolamide 2% b.d. (n=91) or topical latanoprost 0.005% o.d. (n = 91). One year post treatment, the mean percentage reduction in intraocular pressure (IOP) between the three groups was statistically significant (p < 0.0001). In an intergroup comparison of efficacy, there was a statistically significant difference between the brimonidine and dorzolamide groups (p = 0.018) and between the dorzolamide and latanoprost groups (p = 0.76) but the efficacy of brimonidine was not significantly higher than latanoprost in the brimonidine and latanoprost groups (p = 0.002). Patients experiencing mild to severe side-effects were statistically similar in the three groups. On an inter-drug comparison of side-effects, we found no statistically significant difference in the brimonidine and latanoprost groups (p = 0.25); and the brimonidine and dorzolamide groups (p = 0.067), while the number of side-effects with latanoprost was significantly higher in the dorzolamide and latanoprost groups (p<0.003). All three drugs caused a significant reduction in the mean IOP from pretreatment values. The brimonidine group had a higher number of patients experiencing severe side-effects necessitating alteration of therapy.     

Normal values for inner intercanthal,interpupillary, and outer intercanthal distances in the Indian population

The purpose of this study was to establish a set of normal values for inner intercanthal distance (IICD), interpupillary distance (IPD) and outer intercanthal distance (OICD) in a normal Indian population aged 3-80 years and to find whether the difference between the values of these parameters is statistically significant. We also aimed to compute a regression equation for calculating these. Two thousand five hundred clinically normal Indians were enrolled in the study. A millimeter scale was used to measure IPD and IICD. OICD was measured from the bar reading of Hertel's exophthalmometer. Statistical methods were used to calculate the mean and standard deviation values for these parameters. T-test was applied to determine whether difference between the mean values for these parameters in both sexes was statistically significant or not. A regression equation was also computed to find the values for these parameters in both sexes. The IICD, IPD and OICD ranges for males were 20-36 mm, 46-70 mm and 76-105 mm, and for females 20-36 mm, 46-75 mm and 71-105 mm, respectively The difference between the mean values for these parameters was statistically significant in some age groups but not in others. Gender did not usually influence the normal values for IICD, IPD and OICD in the Indian population. The normal values of these parameters were usually lower than those observed for other races. A knowledge of normal values in this population subgroup can help in studying orbito-cranial growth patterns, syndrome diagnosis, surgical management of cranio-facial deformities and trauma, and manufacture of spectacles.     

Renal lymphangiomatosis: a rare cause of bilateral nephromegaly

We report the ultrasound, excretory urography and MR findings in a young child with renal lymphangiomatosis who presented with gradually progressive bilateral flank swelling but who was otherwise asymptomatic. The typical perirenal and parapelvic cysts are visualized as hypoechoic lesions on sonography and hyperintense on T2-weighted HASTE images. T1-weighted image could not delineate the cysts clearly. The renal parenchyma was hyperechoic on sonography, and MRI showed reversal of the normal corticomedullary signal intensity, and confirmed the diagnosis by suggesting the non-parenchymal origin of the cysts.