全文获取类型
收费全文 | 35352篇 |
免费 | 1982篇 |
国内免费 | 142篇 |
专业分类
耳鼻咽喉 | 394篇 |
儿科学 | 1622篇 |
妇产科学 | 884篇 |
基础医学 | 4253篇 |
口腔科学 | 953篇 |
临床医学 | 2400篇 |
内科学 | 7409篇 |
皮肤病学 | 958篇 |
神经病学 | 2832篇 |
特种医学 | 1098篇 |
外科学 | 4430篇 |
综合类 | 781篇 |
现状与发展 | 1篇 |
一般理论 | 23篇 |
预防医学 | 2205篇 |
眼科学 | 1511篇 |
药学 | 2928篇 |
中国医学 | 228篇 |
肿瘤学 | 2566篇 |
出版年
2023年 | 291篇 |
2022年 | 669篇 |
2021年 | 1284篇 |
2020年 | 680篇 |
2019年 | 942篇 |
2018年 | 1129篇 |
2017年 | 827篇 |
2016年 | 1001篇 |
2015年 | 932篇 |
2014年 | 1370篇 |
2013年 | 1710篇 |
2012年 | 2435篇 |
2011年 | 2555篇 |
2010年 | 1362篇 |
2009年 | 1181篇 |
2008年 | 1842篇 |
2007年 | 1857篇 |
2006年 | 1850篇 |
2005年 | 1615篇 |
2004年 | 1493篇 |
2003年 | 1289篇 |
2002年 | 1132篇 |
2001年 | 814篇 |
2000年 | 783篇 |
1999年 | 665篇 |
1998年 | 285篇 |
1997年 | 233篇 |
1996年 | 181篇 |
1995年 | 183篇 |
1994年 | 145篇 |
1993年 | 123篇 |
1992年 | 418篇 |
1991年 | 434篇 |
1990年 | 371篇 |
1989年 | 368篇 |
1988年 | 316篇 |
1987年 | 284篇 |
1986年 | 261篇 |
1985年 | 257篇 |
1984年 | 196篇 |
1983年 | 143篇 |
1982年 | 87篇 |
1981年 | 100篇 |
1979年 | 168篇 |
1978年 | 104篇 |
1977年 | 92篇 |
1975年 | 85篇 |
1974年 | 112篇 |
1973年 | 100篇 |
1972年 | 125篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
The effect of solvent conditions on the aggregation of IgM in serum specimens from patients with macroglobulinemia was studied by a turbidimetric procedure. Aggregation of IgM varied considerably among the samples and was affected by a number of experimental parameters. In general, IgM aggregation was more pronounced under acidic conditions and in solvents with low ionic strength. The presence of water-miscible organic solvents also promoted aggregation. Based on these studies, it was concluded that the major force involved in the formation of immunoglobulin aggregates in the serum of patients with macroglobulinemia was electrostatic, rather than hydrophobic, interactions. A number of additives known to prevent protein aggregation were evaluated for their effectiveness in inhibiting IgM aggregation. The only additives that were shown to inhibit or reduce IgM aggregation were charged molecules, such as arginine, sodium chloride, ethylenediamintetraacetic acid and quaternary ammonium beta-cyclodextrin. Some of these charged additives were also effective in dissociating the IgM aggregates once they were formed, even in the presence of detergent. 相似文献
82.
D. K. Bhargava M.D. Ph.D. B. Singh D.M. R. Dogra D.M. S. Dasarathy D.M. M. P. Sharma D.M. 《The American journal of gastroenterology》1992,87(2):182-186
A prospective randomized controlled study was designed to evaluate differences in efficacy and complication rate between the two most commonly used sclerosing agents, sodium tetradecyl sulfate (STD) and polidocanol. Of 52 patients with esophageal variceal bleeding, 26 were randomized to receive sclerotherapy with 1.5% STD and 26 to receive 1% polidocanol at weekly intervals. Eradication of varices was achieved in 88% patients each of the STD and polidocanol group. There was no significant difference between patients injected with STD and polidocanol with regard to re-bleeding (27% vs. 15%) and mortality (11.5% in both). The use of STD, in contrast to polidocanol, was associated with a higher incidence of complications in terms of severe retrosternal pain (27% vs. 4%), deep ulceration (53% vs. 23%), dysphagia (88% vs. 46%), and stricture formation (27% vs. 8%). It was concluded that these two agents were similar in efficacy. However, polidocanol was superior due to a lower incidence of complications. 相似文献
83.
R Guleria Y K Batra B K Sharma S K Jindal 《The Indian journal of chest diseases & allied sciences》1992,34(3):149-152
A patient of chronic obstructive pulmonary disease (COPD) with cor-pulmonale and chronic respiratory failure, who was given intermittent positive pressure ventilation at home, is reported. The patient did remarkably well on home mechanical ventilatory support. We believe this to be the first case report of domiciliary mechanical ventilation in a patient of COPD from India. 相似文献
84.
We compared the antihypertensive effects and tolerability of a new calcium channel antagonist felodipine with nifedipine in an open randomised parallel group study in 49 patients with moderate hypertension (diastolic blood pressure 105-120 mm Hg). After two weeks run in period felodipine 5 mg and 10 mg once daily was compared with nifedipine 10 mg tid for an active treatment period of 4 weeks. Twenty three patients (mean age 42 +/- 10 years) received felodipine 5 mg once daily for first 2 weeks and 10 mg once daily for subsequent 2 weeks. Twenty six patients (mean age 45 +/- 9 years) received nifedipine 10 mg tid for 4 weeks. The mean reduction in supine diastolic blood pressure in two groups was 17 +/- 6 mm Hg (nifedipine) and 19 +/- 8 mm Hg (felodipine) (p = NS). The goal diastolic blood pressure of less than or equal to 90 mm Hg was achieved in 31 percent (nifedipine group) and 43.5 percent (felodipine group) of patients (p = NS). Side effects were common with both drugs; however, the tolerability was better with felodipine than with nifedipine. In conclusion felodipine was as effective as nifedipine and had the advantage of once a day dosage. 相似文献
85.
Atul K. Sharma Moira S. Mills Vijay L. Grey Keith N. Drummond 《Pediatric nephrology (Berlin, Germany)》1997,11(6):711-713
Accurate, timed urine collections for the measurement of glomerular filtration rate (GFR) may be impractical in infants or
in patients with urological abnormalities. GFR may be measured without urine collection using a constant subcutaneous infusion
of iothalamate. We compare the infusion clearance with conventional renal clearance in 14 children and young adults. The mean
clearance ratio (infusion clearance/renal clearance ± 1 SD) was 0.99±0.1 and the mean discrepancy between the two methods
was 8.5%±4.7%. The 95% limits of agreement for the ratio of the two methods are 0.83–1.23. These data indicate that subcutaneous
infusion of iothalamate is a practical method for measuring GFR in children without a urine collection.
Received March 18, 1996; received in revised form February 12, 1997; accepted March 26, 1997 相似文献
86.
C S Pant D K Gupta R C Sharma A S Gautam R M Bhatt 《Indian journal of malariology》1992,29(4):235-239
Frequency of sickle cell in Scheduled Caste and Scheduled Tribe populations was found to be 1.5 and 14.9% respectively, whereas G-6-PD deficiency was 5.9 and 4.2% respectively. Blood group B was dominant in both the communities. A significantly lower frequency of P. falciparum malaria was observed among sicklers. 相似文献
87.
R Stasi M Conforti G Del Poeta M D Simone U Coppetelli M Tribalto M Cantonetti A Perrotti A Venditti G Papa 《Haematologica》1992,77(6):518-521
Plasma levels of several soluble factors were assayed in 31 untreated patients with high-grade non-Hodgkin's lymphomas (NHL). The results showed statistically significant higher average levels of interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-2 receptor (IL-2r) and transferrin receptor (TF-r) in NHL patients compared to controls (p = 0.045, p = 0.047, p = 0.020, p = 0.026 and p = 0.033 respectively). IL-2, IL-2r and TF-r levels were found more elevated in Stages III/IV than in Stages I/II (p = 0.031, p = 0.016 and p = 0.048 respectively), whereas IL-6 concentrations were higher in patients presenting B symptoms (p = 0.011). Significant correlations were found between the erythrocyte sedimentation rate (ESR) and IL-6 (r = 0.681), and between beta 2 microglobulin (B2-m) and IL-2r (r = 0.622). 相似文献
88.
Neurological Sciences - The diagnostic pathway in a patient with vertigo starts with the accurate evaluation of medical history followed by a general physical and neurological examination. This... 相似文献
89.
90.
Madhuri Dadwal Chander Mohan D. R. Sharma 《Indian journal of otolaryngology and head and neck surgery》2007,59(3):261-263
Secondary tuberculosis of pharynx is a rare condition as pharynx is not a common site for clinically manifest tuberculosis.
A rare and unusual case of secondary oropharyngeal tuberculosis in a 40 years male patient, who presented with an ulceroproliferative
lesion of oropharynx extending to nasopharynx and laryngopharynx is being reported. 相似文献