全文获取类型
收费全文 | 10850篇 |
免费 | 689篇 |
国内免费 | 65篇 |
专业分类
耳鼻咽喉 | 62篇 |
儿科学 | 246篇 |
妇产科学 | 281篇 |
基础医学 | 1541篇 |
口腔科学 | 396篇 |
临床医学 | 996篇 |
内科学 | 2216篇 |
皮肤病学 | 190篇 |
神经病学 | 1334篇 |
特种医学 | 327篇 |
外科学 | 1253篇 |
综合类 | 24篇 |
现状与发展 | 1篇 |
一般理论 | 8篇 |
预防医学 | 979篇 |
眼科学 | 122篇 |
药学 | 690篇 |
中国医学 | 49篇 |
肿瘤学 | 889篇 |
出版年
2024年 | 17篇 |
2023年 | 121篇 |
2022年 | 247篇 |
2021年 | 422篇 |
2020年 | 257篇 |
2019年 | 392篇 |
2018年 | 429篇 |
2017年 | 341篇 |
2016年 | 393篇 |
2015年 | 367篇 |
2014年 | 463篇 |
2013年 | 608篇 |
2012年 | 868篇 |
2011年 | 849篇 |
2010年 | 453篇 |
2009年 | 427篇 |
2008年 | 676篇 |
2007年 | 641篇 |
2006年 | 633篇 |
2005年 | 570篇 |
2004年 | 535篇 |
2003年 | 472篇 |
2002年 | 383篇 |
2001年 | 116篇 |
2000年 | 84篇 |
1999年 | 112篇 |
1998年 | 58篇 |
1997年 | 69篇 |
1996年 | 41篇 |
1995年 | 34篇 |
1994年 | 32篇 |
1993年 | 24篇 |
1992年 | 54篇 |
1991年 | 64篇 |
1990年 | 35篇 |
1989年 | 41篇 |
1988年 | 32篇 |
1987年 | 33篇 |
1986年 | 29篇 |
1985年 | 28篇 |
1984年 | 25篇 |
1983年 | 8篇 |
1982年 | 17篇 |
1981年 | 9篇 |
1980年 | 8篇 |
1979年 | 12篇 |
1977年 | 11篇 |
1974年 | 12篇 |
1973年 | 8篇 |
1971年 | 8篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
61.
Alice Ramondetta Simone Ribero Pietro Quaglino Paolo Broganelli 《Emerging infectious diseases》2021,27(1):281
Fluorescence-advanced videodermatoscopy is not a widespread diagnostic technique. Its application in dermatology can facilitate the diagnosis of diseases such as cutaneous larva migrans by enabling us to recognize the precise position of larva in vivo on the skin. Using this noninvasive technique, we detected a case of cutaneous larva migrans in a patient. 相似文献
62.
Lobo Sylvia J. Lin Jessica G. Vais Simone Wang Dongyu Adegoke Tejumola M. Wu Wan-Ju Steer-Massaro Courtney 《Journal of immigrant and minority health / Center for Minority Public Health》2022,24(1):111-117
Journal of Immigrant and Minority Health - Although multiple studies have shown that resettled refugee women are less likely to receive preventative cancer screenings like pap smears and... 相似文献
63.
Chimello-Sousa Daniela Thomazatti Lavez Geovane Praxedes Fernandes Roger Rodrigo Tavares Milla Sprone Rosa Adalberto Luiz Siessere Selma Regalo Simone Cecílio Hallak Bombonato-Prado Karina Fittipaldi 《Lasers in medical science》2021,36(9):1979-1988
Lasers in Medical Science - The purpose of this study is to analyze the influence of InGaAlP diode laser (660 nm) with or without an odontogenic medium (OM) in the functional activity of... 相似文献
64.
Carlo Giulioni Valentina Maurizi Simone Scarcella Manuel Di Biase Valerio Iacovelli Andrea Benedetto Galosi Daniele Castellani 《Andrologia》2021,53(11):e14215
Our purpose was to review and analyse the impact of pyrethroids and organophosphates exposure on human semen parameters. A comprehensive literature search was performed through MEDLINE via PubMed, Scopus and Webscience. Only cohort studies examining semen parameters in workers or general populations exposed to pyrethroids or organophosphates were included. Ejaculate volume, sperm count, concentration, motility, viability, normal morphology and seminal pH alterations were pooled using the Cochran–Mantel–Haenszel Method with the random effect model and expressed as weighted mean difference, risk ratios, 95% confidence intervals and p-values. Seven cross-sectional studies regarding pyrethroids were included. Four of them were eligible for meta-analysis. The only parameter affected by pyrethroid exposure was normal sperm morphology (WMD-7,61%, 95%CI –11,92 to −3,30;p = 0,0,005). Nine studies were selected to evaluate the impact of organophosphates on semen parameters with six of them eligible for meta-analysis. A significant reduction was detected for the following: ejaculate volume (WMD −0,47ml, 95%CI −0,69 to −0,25; p < 0,0001), sperm count (WMD-40,03, 95%CI −66,81 to −13,25;p = 0,003), concentration (WMD-13,69 x10⁶/mL, 95%CI −23, 27 to-4,12;p = 0,005) and motility (WMD −5,70%, 95%CI −12,89 to 1,50;p = 0,12). Despite the increase in sperm abnormality, it has been shown that pyrethroids are unrelated to reduced sperm quality. However, the negative association of organophosphates with spermatogenesis is noteworthy. 相似文献
65.
Luigi Gennari Daniela Merlotti Natale Figura Christian Mingiano Maria Beatrice Franci Barbara Lucani Tommaso Picchioni Mario Alessandri Maria Stella Campagna Sara Gonnelli Simone Bianciardi Maria Materozzi Carla Caffarelli Stefano Gonnelli Ranuccio Nuti 《Journal of bone and mineral research》2021,36(1):80-89
Helicobacter pylori (HP) infection is a common and persistent disorder acting as a major cofactor for the development of upper gastrointestinal diseases and several extraintestinal disorders including osteoporosis. However, no prospective study assessed the effects of HP on bone health and fracture risk. We performed a HP screening in a population-based cohort of 1149 adults followed prospectively for up to 11 years. The presence of HP infection was assessed by serologic testing for serum antibodies to HP and the cytotoxin associated gene-A (CagA). The prevalence of HP infection did not differ among individuals with normal bone mineral density (BMD), osteoporosis, and osteopenia. However, HP infection by CagA-positive strains was significantly increased in osteoporotic (30%) and osteopenic (26%) patients respect to subjects with normal BMD (21%). Moreover, anti-CagA antibody levels were significantly and negatively associated with lumbar and femoral BMD. Consistent with these associations, patients affected by CagA-positive strains had a more than fivefold increased risk to sustain a clinical vertebral fracture (HR 5.27; 95% CI, 2.23–12.63; p < .0001) and a double risk to sustain a nonvertebral incident fracture (HR 2.09; 95% CI, 1.27–2.46; p < .005). Reduced estrogen and ghrelin levels, together with an impaired bone turnover balance after the meal were also observed in carriers of CagA-positive HP infection. HP infection by strains expressing CagA may be considered a risk factor for osteoporosis and fractures. Further studies are required to clarify in more detail the underlying pathogenetic mechanisms of this association. © 2020 American Society for Bone and Mineral Research (ASBMR). 相似文献
66.
Ebbe Eldrup Simone Theilade Mette Lorenzen Christine H Andreassen Katrine H Poulsen John E Nielsen Ditte Hansen Daniel El Fassi Jais O Berg Per Bagi Anne Jørgensen Martin Blomberg Jensen 《Journal of bone and mineral research》2021,36(2):322-333
Intramuscular injections of paraffin oil can cause foreign body granuloma formation and hypercalcemia. Macrophages with the ability to produce high levels of 1,25(OH)2D3 may induce the mineral disturbance, but no major series of patients have been published to date. Here, medical history, physical evaluation, biochemical, and urinary analysis for calcium homeostasis were obtained from 88 males, who 6 years previously had injected paraffin or synthol oil into skeletal muscle. Moreover, granuloma tissue from three men was cultured for 48 hours ex vivo to determine 1,25(OH)2D3 production supported by qPCR and immunohistochemistry of vitamin D metabolism and immune cell populations after treatment with 14 different drugs. The 88 men were stratified into men with hypercalcemia (34%), whereas normocalcemic men were separated into men with either normal (42%) or suppressed parathyroid hormone (PTH) (24%). All men had high calcium excretion, and nephrolithiasis was found in 48% of hypercalcemic men, 22% of normocalcemic men with normal PTH, and 47% of normocalcemic men with suppressed PTH. Risk factors for developing hypercalcemia were oil volume injected, injection of heated oil, high serum interleukin-2 receptor levels, and high urine calcium. High 1,25(OH)2D3/25OHD ratio, calcium excretion, and low PTH was associated with nephrolithiasis. The vitamin D activating enzyme CYP27B1 was markedly expressed in granuloma tissue, and 1,25(OH)2D3 was released in concentrations corresponding to 40% to 50% of the production by human kidney specimens. Dexamethasone, ketoconazole, and ciclosporin significantly suppressed granulomatous production of 1,25(OH)2D3. In conclusion, this study shows that injection of large oil volumes alters calcium homeostasis and increases the risk of nephrolithiasis. Hypercalciuria is an early sign of disease, and high granulomatous 1,25(OH)2D3 production is part of the cause. Prospective clinical trials are needed to determine if ciclosporin, ketoconazole, or other drugs can be used as prednisolone-sparing treatment. © 2020 American Society for Bone and Mineral Research (ASBMR). 相似文献
67.
Andrea D’Ambrosio Caroline Toulouse Samuel Bélanger-Marceau Simone Savary Sunita Mathur Bianca Segatto David Hartell Tania Janaudis-Ferreira 《Transplantation proceedings》2021,53(2):581-589
BackgroundThe Canadian Transplant games (“Games”) were created to increase awareness of organ donation and highlight the importance of staying active and healthy post-transplant. It is unclear what motivates solid organ transplant (SOT) recipients to participate and whether the games serve as an incentive for SOT recipients to increase their physical activity (PA) levels.Objectives1. To describe the characteristics of participants from past games and their motivation for attending and 2. to determine whether there was an interest in participating in goal-based, pre-games exercise training programs.MethodsA web-based questionnaire was sent to adult SOT recipients who were members of the Canadian Transplant Association. The survey included questions about why participants attended, their PA levels, and their interest in a pre-games training program.ResultsOf the 157 participants, more were male than female; the 35-54-year-old age group was the most common; and 62% of respondents received a liver or kidney transplant. The most common reasons for participating in the games were to showcase health post-transplant, promote awareness of organ donation, sports competition, and social reasons. Sixty-five percent of respondents reported that they would be interested in an exercise program to be more physically prepared for the competition.ConclusionPre-games training programs could be developed to motivate participation and help participants achieve higher training intensities and foster social interaction. Directing resources to individuals who do not attend the games and to those who are not physically active should be considered. 相似文献
68.
La Mendola Roberta Bencivenga Maria Torroni Lorena Alberti Luca Sacco Michele Casella Francesco Ridolfi Cecilia Simoni Nicola Micera Renato Pavarana Michele Verlato Giuseppe Giacopuzzi Simone 《Annals of surgical oncology》2021,28(6):3034-3043
Annals of Surgical Oncology - Although pathological complete response (pCR) after multimodal treatment for esophageal cancer is associated to the best prognosis, recurrence may occur in... 相似文献
69.
La Mendola Roberta Bencivenga Maria Torroni Lorena Sacco Michele Giacopuzzi Simone 《Annals of surgical oncology》2021,28(6):3044-3045
Annals of Surgical Oncology - 相似文献
70.
Giulia Marvaso Marianna Montesano Giulia Corrao Simone P. De Angelis Sara Gandini Giovanni C. Mazzola Matteo Augugliaro Jessica Franzetti Dario Zerini Matteo Pepa Stefano Luzzago Francesco A. Mistretta Gennaro Musi Franco Nolè Ottavio De Cobelli Roberto Orecchia Barbara A. Jereczek-Fossa 《BJU international》2021,127(4):454-462