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排序方式: 共有6552条查询结果,搜索用时 15 毫秒
91.
Antonello D’Andrea Juri Radmilovic Stefano Caselli Andreina Carbone Raffaella Scarafile Simona Sperlongano Giampaolo Tocci Tiziana Formisano Francesca Martone Biagio Liccardo Michele D’Alto Eduardo Bossone Maurizio Galderisi Paolo Golino 《The international journal of cardiovascular imaging》2018,34(10):1561-1561
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93.
Mura Eleonora Masnada Silvia Antonello Clara Parazzini Cecilia Izzo Giana Garau Jessica Sproviero Daisy Cereda Cristina Orcesi Simona Veggiotti Pierangelo Zuccotti Gianvincenzo Dilillo Dario Penagini Francesca Tonduti Davide 《Metabolic brain disease》2021,36(5):859-863
Metabolic Brain Disease - Aicardi-Goutières Syndrome (AGS) is a monogenic leukodystrophy with pediatric onset, clinically characterized by a variable degree of neurologic impairment. It... 相似文献
94.
Non-alcoholic fatty liver syndrome: a hepatic consequence of common metabolic diseases 总被引:11,自引:0,他引:11
Angelico F Del Ben M Conti R Francioso S Feole K Maccioni D Antonini TM Alessandri C 《Journal of gastroenterology and hepatology》2003,18(5):588-594
BACKGROUND AND AIMS: The association of liver steatosis with a number of common metabolic conditions has been suggested. The aim of the present study was to evaluate the clinical features of subjects with different severities of steatosis. METHODS: The present study was performed in 282 consecutive patients with 'bright liver' at ultrasonography and in 58 subjects without steatosis. They had no history of alcohol abuse and negative tests for the presence of hepatitis B and C virus. Patients underwent clinical examination, anthropometry, laboratory tests and routine liver ultrasonography. Steatosis was graded as absent, mild, moderate and severe. RESULTS: A progressive increase in the prevalence of obesity (P < 0.001), type 2 diabetes (P < 0.001), alanine aminotransferase (ALT) elevation (P < 0.001) and hypertriglyceridemia (P < 0.001), and a decrease of hypercholesterolemia (P < 0.05) was observed from the control group to the groups with mild, moderate and severe steatosis. More than half the subjects with liver steatosis had insulin resistance metabolic syndrome. Obesity, diabetes and hypertriglyceridemia were more common by 5.3-fold, 4.0-fold, and 6.7-fold, respectively, in subjects with severe steatosis, as compared to controls. Prevalence of obesity, diabetes and hyperlipidemia was significantly higher in subjects with fatty liver and ALT elevation. CONCLUSION: Fatty liver can be considered as the hepatic consequence of common metabolic diseases. 相似文献
95.
Vitale M Caruso A De Francesco MA Rodella L Bozzo L Garrafa E Grassi M Gobbi G Cacchioli A Fiorentini S 《British journal of haematology》2003,120(2):337-343
We investigated the effects of human immunodeficiency type-1 virus (HIV-1) matrix protein p17 on freshly isolated and purified human natural killer (NK) cells. HIV-1 p17 increased the cytokines interleukin (IL) 2, IL-12 and IL-15, and induced natural killer cell proliferation, but not cytotoxicity. This effect was specific because it was abrogated by anti-p17 monoclonal antibody. Moreover, HIV-1 p17 enhanced the cytokine-induced production of tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma by NK cells. IL-4 downregulated IFN-gamma and TNF-alpha secretion in IL-2- and IL-15-treated NK cells. HIV-1 p17 restored the ability of NK cells to produce both cytokines when added to the cultures simultaneously with IL-4. The property of p17 to increase the production of TNF-alpha and IFN-gamma might be a mechanism used by HIV-1 to modulate the immune system to support its replication and spreading. 相似文献
96.
Petrutiu Simona; Sahakian Alan V.; Swiryn Steven 《Europace : European pacing, arrhythmias, and cardiac electrophysiology》2007,9(7):466-470
Aims We investigated the process of spontaneous terminationof atrial fibrillation (AF) to determine its time course fromthe surface ECG. Methods and results We studied fibrillatory waves in Holterrecordings of paroxysmal and sustained AF. Following QRS-T cancellationdominant frequencies (DFs) were computed and the relationshipof DF to termination was scrutinized. For 57 episodes of paroxysmalAF (PAF) in 24 patients, DF ranged from 4.4 to 6.5 Hz (5.2 ±0.4 Hz) compared to 5.8 to 7.4 Hz (6.6 ± 0.6 Hz) forsustained AF recordings. Comparison of the atrial frequencyof the ultimate to the penultimate second demonstrated a dropin frequency in 51 of 57 episodes, P < 0.00001. No comparablechange was seen at longer time periods. Moments of comparablylow frequency without termination were only occasionally seenin patients with PAF but not in patients with sustained AF. Conclusion Low frequency fibrillation was found to be much morelikely to terminate. Frequency changes preceding spontaneoustermination were abrupt, in contrast to the gradual frequencydrop reported with drug-induced termination. The analysis offibrillatory wave characteristics and their change over timemight be used to target specific moments for pacing therapyin patients with AF. 相似文献
97.
Maria Carla Roncaglioni Fausto Avanzini Daria Roccatagliata Lara Monesi Darina Tamayo-Benitez Massimo Tombesi Vittorio Caimi Paolo Longoni Davide Lauri Simona Barlera Gianni Tognoni 《European journal of cardiovascular prevention and rehabilitation》2004,11(3):233-238
BACKGROUND: Although risk assessment charts have been proposed to identify patients at high cardiovascular risk, in everyday practice general practitioners (GPs) often use their knowledge of the patients to estimate the risk subjectively. DESIGN: A cross-sectional study aimed to describe how GPs perceive, qualify and grade cardiovascular risk in everyday practice. METHODS: General practitioners had to identify in a random sample of 10% of their contacts the first 20 consecutive patients perceived as being at cardiovascular risk. For each patient essential data were collected on clinical history, physical examination and laboratory tests, for the qualification of risk. At the end of the process GPs subjectively estimated the overall patient's level of risk. General practitioners grading was compared with the risk estimate from a reference chart. RESULTS: Over a mean time of 25 days 3120 patients perceived as being at cardiovascular risk were enrolled. According to the inclusion scheme each GP had contact with more than 200 patients at cardiovascular risk every month. Thirty percent of these patients had atherosclerotic diseases. Up to 72% of patients without any history of atherosclerotic diseases but perceived to be at risk could be classified according to a reference chart as being at moderate to very high risk. Comparing GPs' grading of risk with a chart estimate there was agreement in 42% of the cases. Major determinants of GPs' underestimation of risk were age, sex and smoking habits, while obesity and family history were independently associated with overestimation. CONCLUSIONS: On the basis of their perception GPs properly identify patients at cardiovascular risk in the majority of cases. General practitioners subjective grading of risk level only partially agreed with that given by a chart. 相似文献
98.
Piero Olliaro Luciano Lombardi Simona Frigerio Nicoletta Basilico Donatella Taramelli Diego Monti 《Ultrastructural pathology》2013,37(1):9-13
Hemozoin, the detoxification product of hemoglobin heme, piles up as electron-dense material in the food vacuole (FV) of intraerythrocytic malaria parasites (malaria pigment). In infected individuals, pigment is internalized by both circulating and resident phagocytes, thus modulating their functions. Synthetic beta-hematin, prepared in vitro from hematin (ferriprotoporphyrin IX hydroxide) in acidic condition, is spectroscopically identical to hemozoin. In this electron microscopy study, native and synthetic hemozoin also prove to be morphologically indistinguishable (large polygonal crystals with apparent transverse banding) and to undergo the same process when internalized by phagocytes (primarily a direct uptake of crystals, similar to what is described for asbestos fibers). On the contrary,whole parasites appear to follow a classical endocytic pathway. This suggests that there may be differences between the ingestion of free particles and whole parasites in terms of modulation of phagocytes' functions. 相似文献
99.
Paolo Ditonno Roberto Ria Ilaria Marech Annunziata De Luisi Simona Berardi Maria Antonia Frassanito Emanuele Angelucci Daniele Derudas Giorgina Specchia Paola Curci Vincenzo Pavone Bernardo Rossini Domenico Ribatti Barbara Bottazzi Alberto Mantovani Marco Presta Franco Dammacco Angelo Vacca 《The Journal of pathology》2013,229(1):87-98
Pentraxin 3 (PTX3) is a soluble pattern recognition receptor that binds with high affinity and selectivity to fibroblast growth factor‐2 (FGF2), thus inhibiting its pro‐angiogenic activity. Here we investigated the effects of PTX3 on monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) patient‐derived bone marrow (BM) plasma cells (PCs), endothelial cells (ECs), and fibroblasts (FBs), and assessed whether PTX3 can modulate the cross‐talk between PCs and those microenvironment cells. PTX3 and FGF2 expression was evaluated by ELISA. Functional studies, including cell viability, wound healing, chemotaxis, and Matrigel® assays, were performed on MGUS and MM ECs and FBs upon the PTX3 treatment. Through western blot PTX3‐induced modulation in FGF2/FGF receptor signalling pathways was evaluated in MGUS and MM ECs and FBs through western blot. Co‐cultures between MM ECs/FBs and human PC lines were used to evaluate possible PTX3 indirect effects on MM PCs. Adhesion molecules were studied by flow cytometry. PTX3 provides a direct time‐ and dose‐dependent apoptotic effect on MM ECs and FBs, but not on either MM primary PCs or human PC lines. PTX3 inhibits migration of MM ECs and FBs in a dose‐dependent manner, and impacts in vitro and in vivo FGF2‐mediated MM angiogenesis. Co‐cultures of PCs and ECs/FBs show that PTX3 treatment indirectly impairs PC viability and adhesion. We conclude that PTX3 is an anti‐angiogenic factor in MM and behaves as a cytotoxic molecule on MM cells by inhibiting the cross‐talk between PCs and ECs/FBs. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. 相似文献
100.