全文获取类型
收费全文 | 935214篇 |
免费 | 65107篇 |
国内免费 | 2448篇 |
专业分类
耳鼻咽喉 | 12799篇 |
儿科学 | 29635篇 |
妇产科学 | 26793篇 |
基础医学 | 131671篇 |
口腔科学 | 25279篇 |
临床医学 | 78603篇 |
内科学 | 190635篇 |
皮肤病学 | 19740篇 |
神经病学 | 75052篇 |
特种医学 | 37772篇 |
外国民族医学 | 347篇 |
外科学 | 146926篇 |
综合类 | 19451篇 |
一般理论 | 277篇 |
预防医学 | 67634篇 |
眼科学 | 20780篇 |
药学 | 66298篇 |
中国医学 | 1903篇 |
肿瘤学 | 51174篇 |
出版年
2019年 | 7235篇 |
2018年 | 10085篇 |
2017年 | 7974篇 |
2016年 | 8585篇 |
2015年 | 9695篇 |
2014年 | 13652篇 |
2013年 | 20838篇 |
2012年 | 28153篇 |
2011年 | 29878篇 |
2010年 | 18054篇 |
2009年 | 17015篇 |
2008年 | 28128篇 |
2007年 | 29875篇 |
2006年 | 29933篇 |
2005年 | 29309篇 |
2004年 | 28035篇 |
2003年 | 26943篇 |
2002年 | 26413篇 |
2001年 | 41911篇 |
2000年 | 43090篇 |
1999年 | 36783篇 |
1998年 | 10295篇 |
1997年 | 9400篇 |
1996年 | 9324篇 |
1995年 | 8667篇 |
1994年 | 8260篇 |
1993年 | 7734篇 |
1992年 | 28502篇 |
1991年 | 27277篇 |
1990年 | 26693篇 |
1989年 | 25577篇 |
1988年 | 23788篇 |
1987年 | 23437篇 |
1986年 | 22521篇 |
1985年 | 21404篇 |
1984年 | 16015篇 |
1983年 | 13648篇 |
1982年 | 8208篇 |
1979年 | 14805篇 |
1978年 | 10362篇 |
1977年 | 8768篇 |
1976年 | 8273篇 |
1975年 | 9066篇 |
1974年 | 10834篇 |
1973年 | 10319篇 |
1972年 | 9770篇 |
1971年 | 9030篇 |
1970年 | 8674篇 |
1969年 | 8119篇 |
1968年 | 7777篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
121.
JANE P. F. BAI HAE-JIN HONG DAVID A. ROTH ENBERGER W. DOUGLAS WONG JOHN G. BULS 《The Journal of pharmacy and pharmacology》1996,48(11):1180-1184
The aim of this research is to characterize the presence of insulin-degrading enzyme in human colon and ileal mucosal cells. Biochemical studies, including the activity-pH profiles, the effects of enzyme inhibitors, immunoprecipitation and western blots, were conducted. The majority of insulin-degrading activity in colon mucosal cells was localized in the cytosol. In both colon and ileum, cytosolic insulin-degrading activities had a pH optimum at pH 7.5, and were extensively inhibited by each of N-ethylmaleimide, p-chloromercuribenzoate, and 1,10-phenanthroline, but were very weakly affected by each of leupeptin, chymostatin, diisopropyl phosphofluoridate and soybean trypsin inhibitor. In the colon and ileum, more than 93% and 96%, respectively, of cytosolic insulin-degrading activities were removed by the mouse monoclonal antibody to human RBC insulin-degrading enzyme, as compared with less than 20% by the normal mouse IgG for both tissues. Further, a western blot analysis revealed that a cytosolic protein of 110 kD, in both human colon and ileum, reacted with the monoclonal antibody to insulin-degrading enzyme. It is concluded that insulin-degrading enzyme is present in the cytosol of human colon and ileal mucosal cells. 相似文献
122.
What is the value of bcl-2 protein detection for histopathologists? 总被引:15,自引:0,他引:15
123.
Our study was intended to determine whether power Doppler sonography can be considered superior to color Doppler technique in depiction of normal orbital vasculature. Ten healthy volunteers (20 eyes) were examined with a 10 MHz linear probe; each orbital vessel was recorded with both color and power Doppler methods; the images were reviewed independently by all the observers, who agreed that power Doppler clearly is superior to color Doppler technique for evaluation of the anatomy of orbital arteries and veins. 相似文献
124.
125.
A E van der Merwe F J Mattheyse M Bedford P D van Helden D J Rossouw 《Burns : journal of the International Society for Burn Injuries》1990,16(3):193-197
Cultured keratinocytes were used as allografts on burn wounds in two patients. In both patients successful covering of the wounds was obtained. DNA fingerprinting of the epidermis covering the wounds 21 days later showed that the cultured keratinocytes were replaced by the patients' cells. 相似文献
126.
J Combe P Poinsard J Besancenot G Camelot F Cattin J F Bonneville T Moulin J L Henlin J L Chopard L Cotte 《Annals of vascular surgery》1990,4(6):558-562
Free-floating clots of the extracranial internal carotid artery are generally considered as surgical emergencies. This retrospective study analyzes six free-floating clots diagnosed by arteriography. Three of these patients had a fixed stroke while the other three had an evolving stroke. Three patients had antecedent ocular or hemispheric transient ischemic attacks. The causes of free-floating clots in the internal carotid artery were atheromatous stenosis in two cases, ulcerated plaque in three cases, and carotid artery dissection in one. All six patients were seen late, approximately 15 hours after their neurologic accident. They were treated with intravenous heparin over a two to five week period. Repeat arteriograms demonstrated complete clot lysis in four instances, while partial lysis was seen in one case. Moderate extension of thrombus occurred in one case only. No further neurologic complications were noted during the treatment by heparin. As indicated by follow-up arteriographic findings, secondary surgery was performed for major carotid lesions and residual clots in five cases. The free-floating thrombus syndrome of the carotid artery should not be considered as a surgical emergency when discovered late in the wake of an acute neurologic accident. 相似文献
127.
We report a case of left iliofemoral vein thrombosis with extension to the inferior vena cava associated with giant right hydronephrosis secondary to ureteropelvic junction obstruction. Surgery revealed marked infrarenal vena caval compression and deviation to the left side caused by the dilated right renal pelvis, with resultant kinking of the origin of the left iliac vein. It is postulated that the reduction in blood flow caused by this compression and distortion predisposed this patient to venous thrombosis. 相似文献
128.
129.
A. Taytard J. F. Tessier J. G. Faugere J. Vergeret P. Freour 《European journal of epidemiology》1988,4(3):326-330
Professional exposure to vegetable dusts affect the respiratory function of the exposed subjects. A previous survey conducted in an industrial flour-mill demonstrated a higher frequency of respiratory symptoms in workers compared to a control group. Ten subjects employed in a work site particularly exposed to dust were studied. Each subject answered a questionnaire and performed on Mondays and Fridays, at the begenning and end of his work shift, a flow volume curve and an isocapnic hyperventilation test. The aerobiology of the professional environment was also measured. We noted: 1) in the flow volume curves: a drop in the FEV1 during the Monday morning shift, a significant difference between the FEV1 (p<0.05) and the MMEFR 25–75 (p<0.05) measured at 6 am on Monday and Friday, and between the MMEFR 25–75 values obtained at 12 noon on Monday and Friday (p<0.05). 2) after isocapnic hyperventilation, a significant drop in the MMEFR 25–75 at 6 am on Monday (p<0.01) and in the FEV1 and MMEFR 25–75 at 12 noon on Mondays (p<0.05), a significant drop in the FEV1 at 1 pm on Monday (p<0.01). 相似文献
130.
LUCAS D.; MENEZ J. F.; BODENEZ P.; BACCINO E.; BARDOU L. G.; FLOCH H. H. 《Alcohol and alcoholism (Oxford, Oxfordshire)》1988,23(1):23-31
Acetaldehyde, the first metabolite of ethanol, reacts with haemoglobinin vitro to produce acetaldehydehaemoglobin adducts.Some clinical studies on the minor haemoglobins have suggestedthat these adducts may be formed in people abusing alcohol.Under hydrolysis of haemoglobin, with oxalic acid at 100°Cin sealed vials, some acetaldehyde was released and then specificallydetermined by HPLC. The kinetics of hydrolysis were studiedusing haemoglobin previously labelled with 14[C] acetaldehyde.The maximum liberation of 14[C] acetaldehyde was obtained after3 hr 30 min hydrolysis and this time factor was then utilizedin the analysis of alcoholic and control haemoglobin. Thus,we have confirmed the formation of acetaldehyde haemoglobinadducts in vivo. It must be noted that the released acetaldehydecorresponds only to an index of the stable adducts. The levelswere higher in alcoholics than in controls (1.417±0.171and 1.295±0.139 nmol/mg Hb, respectively, P<0.001).In conclusion, this marker is not a convenient tool for themonitoring of alcohol exposure levels because of the low differencesbetween alcoholic and control haemoglobins. 相似文献