Melioidosis: a review of orthopedic manifestations, clinical features, diagnosis and management

Melioidosis is an infectious disease caused by gram-negative soil-dwelling bacillus Burkholderia pseudomallei. Musculoskeletal melioidosis mimics other infections both clinically and radiologically. An extensive literature review has been performed over musculoskeletal melioidosis through various search engines such as Pubmed, Embase, Medscape, Altavista and Google. Diagnosis requires a high index of clinical suspicion and is dependent on microbiological confirmation. Prompt treatment with long-term combination antibiotics in high dosages and surgical drainage of abscesses improves survival.     

Barbed Versus Traditional Sutures: Closure Time,Cost, and Wound Related Outcomes in Total Joint Arthroplasty

The purpose of this study was to compare barbed sutures to traditional sutures in three domains: time, cost, and wound related outcomes in total knee arthroplasty (TKA) and total hip arthroplasty (THA). A total of 34 patients were enrolled in a prospective randomized controlled trial to assess time to wound closure and cost. In addition, a retrospective chart review of an additional 100 patients was conducted to further assess wound-related outcomes. On average, barbed sutures decreased time to wound closure by 9.72 min (P < 0.05) after controlling for length of incision, patient's BMI and number of physicians closing. Further, using barbed sutures saved an average of $549.59 per case. However, increased frequency and severity of wound complications were associated with barbed sutures.     

In Vitro and In Vivo Study of Argyreia speciosa on Chronic Gastric Ulceration and Metabolic Studies

Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - Chronic gastric ulcer being the most prevalent gastrointestinal disorder is considered a major cause of...     

Post-coital Contraceptive Action of Pueraria tuberosaDC. Extract in Rats

Biochemical and physiological alterations have been observed in the ovary and uterus of pregnant rats treated with an extract of Pueraria tuberosa DC. Its administration from day 1 to 5 post-coitally caused a significant increase in the wet weight, protein and glycogen contents. Activity of acid phosphatase and ATPase was depleted sharply on days 4 and 5, but the activity of alkaline phosphatase was elevated on days 4 and 5. Ovaries of treated rats showed an increased number of follicles of different age. Cells of the corpora lutea showed hypertrophy. Uterine histoarchitecture appeared nonreceptive on the day of implantation. No deciduoma was observed on day 5. These changes have been correlated with the antiimplantation action of the butanol extract.     

Antilipid Peroxidative Property of Shilajit

We have investigated the effect of shilajit on lipid peroxidation and glutathione content in rat liver homogenate. It inhibited lipid peroxidation induced by cumene hydroperoxide and ADP/Fe⁺⁺ complex in a dose dependent manner. It also reduced the rate of oxidation of reduced glutathione content and inhibited ongoing lipid peroxidation, induced by these agents immediately after its addition to the incubation system.     

Antifeedant Activity of Ursolic Acid Isolated from Duboisia Myoporoides

Ursolic acid isolated from the leaves and stems of Duboisia myoporoides (Solanaceae) was bioassayed by leaf disc method for feeding deterrence using Spilosoma obliqua and Spodoptera litura as test insects. This compound was proved to be a potent antifeedant under laboratory conditions. Azadirachtin was used as standard. Ursolic acid produced 90.12% and 91.96% inhibition at 5000 ppm concentration, respectively, against S. obliqua and S. litura .     

Protective Action of Butanolic Extract of Pueraria tuberosa DC. Against Carbon Tetrachloride Induced Hepatotoxicity in Adult Rats

Administration of CCl₄ at a dose of 0.1 mL/kg/day for 7 days to normal rats provoked significant alterations in the various biochemical variables. It also caused severe histopathological lesions. Priming with the butanol extract of P. tuberosa or conjoint administration of extract along with CCl₄, provided significant protection against CCl₄ induced injury.