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81.
Chie Kitahara Shuhei Morita Shohei Kishimoto Shohei Matsuno Shinsuke Uraki Ken Takeshima Yasushi Furukawa Hidefumi Inaba Hiroshi Iwakura Hiroyuki Ariyasu Hiroto Furuta Masahiro Nishi Takashi Akamizu 《Journal of diabetes investigation.》2021,12(4):664-667
We report the first case of intraoperatively detected euglycemic diabetic ketoacidosis (DKA) associated with sodium–glucose cotransporter 2 inhibitors during thoracic surgery. A 59-year-old man had a 12-year history of type 2 diabetes mellitus treated with insulin and empagliflozin. The patient developed bacterial empyema and was initiated with antibiotics at a local hospital. Owing to the persistence of his symptoms, he was transferred to our hospital after the medication of empagliflozin the day before surgery. After overnight fasting, the patient underwent thoracoscopic debridement and intrathoracic lavage surgery. During this surgery, he was noted to have euglycemic ketosis and acidosis, and diagnosed as euglycemic DKA. Immediately after the consultation in our department, the patient underwent treatment for DKA. He awoke from anesthesia normally and showed no symptoms of DKA. DKA gradually resolved over the next 24 h. Early identification and management are critical for rapid recovery from perioperative euglycemic DKA associated with sodium–glucose cotransporter 2 inhibitors, especially during thoracic surgery. 相似文献
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Hiroyuki Hanakawa MD Yorihisa Orita MD PhD Yasuharu Sato MD PhD Soshi Takao MD PhD Hidenori Marunaka MD Tokiwa Morishita MD Yasuhiko Yamashita MD Yasutaka Hori MD Shuhei Domae MD Ikuo Inokuchi MD PhD Seiko Akagi MD Eisei Kondo MD PhD Noriko Iwaki MD Kana Motomiya MD Hirokazu Okumura MD PhD Tadashi Yoshino MD PhD Kazunori Nishizaki MD PhD 《Head & neck》2014,36(4):551-556
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Ono Masateru Azuchi Maako Ichio Misato Jiyoubi Yuki Tsutsumi Shuhei Yasuda Shin Tsuchihasi Ryota Okawa Masafumi Kinjo Junei Yoshimitsu Hitoshi Nohara Toshihiro 《Journal of natural medicines》2019,73(1):11-22
Journal of Natural Medicines - Seven new resin glycosides, multifidins III (1)–IX (7), were isolated from the seeds of Quamoclit?×?multifida (syn. Q. sloteri House)... 相似文献
88.
Kazuhiko Uchiyama Takeshi Ishikawa Naoyuki Sakamoto Hirokazu Kajikawa Tomohisa Takagi Osamu Handa Yoshihide Tatsumi Nobuaki Yagi Yuji Naito Yoshito Itoh Shuhei Takemura 《Journal canadien de gastroenterologie》2014,28(1):31-34
BACKGROUND:
Transnasal esophagogastroduodenoscopy (EGD) without sedation has been reported to be safe and tolerable. It has recently been used widely in Japan for the detection of upper gastrointestinal disease. Alternatively, transoral examination using a thin endoscope has also been reported to be highly tolerable.OBJECTIVE:
To examine the cardiocirculatory effects of transoral versus transnasal EGD in an attempt to determine the most suitable endoscopic methods for patients ≥75 years of age.METHODS:
Subjects who underwent monitoring of respiratory and circulatory dynamics without sedation during endoscopic screening examinations were enrolled at the New Ooe Hospital (Kyoto, Japan) between April 2008 and March 2009. A total of 165 patients (age ≥75 years) provided written informed consent and were investigated in the present study. Patients were randomly divided into three subgroups: UO group – thin endoscope; SO group – standard endoscope; and UT group – transnasal EGD. Percutaneous arterial blood oxygen saturation, heart rate and blood pressure were evaluated just before EGD and at five time points during EGD. After transnasal EGD, patients who had previously been examined using transoral EGD with a standard endoscope were asked about preferences for their next examination.RESULTS:
There were no statistical differences in the characteristics among the groups. Percutaneous oxygen saturation in the UT group showed a transient drop compared with the SO and UO groups at the beginning of the endoscopic procedure. Heart rate showed no significant differences among the SO, UO and UT groups; Systolic blood pressure in the UO group was lower immediately after insertion compared with the SO and UT groups. The rate pressure product in the UO group was comparable with that in the UT group during endoscopy, and the SO group showed a continuously higher level than the UO and UT groups. More than one-half (54.4%) of patients were ‘willing to choose transnasal EGD for next examination’.CONCLUSIONS:
For elderly patients, unsedated transnasal EGD failed to show an advantage over unsedated standard endoscopy. Transoral thin EGD was estimated to be safe and tolerable. 相似文献89.
Shuhei Nishiguchi Hirayuki Enomoto Nobuhiro Aizawa Hiroki Nishikawa Yukio Osaki Yasuhiro Tsuda Kazuhide Higuchi Kazuichi Okazaki Toshihito Seki Soo Ryang Kim Yasushi Hongo Hisato Jyomura Naoshi Nishida Masatoshi Kudo 《Journal of gastroenterology》2014,49(3):492-501
Background
We conducted a multicenter randomized clinical trial to determine the optimal treatment strategy against chronic hepatitis C virus (HCV) with genotype 1b and a high viral load (G1b/high).Methods
The study subjects included 153 patients with G1b/high. Patients were initially treated with PEG-IFNα-2a alone and then randomly assigned to receive different treatment regimens. Ribavirin (RBV) was administered to all patients with HCV RNA at week 4. Patients negative for HCV RNA at week 4 were randomly assigned to receive PEG-IFNα-2a (group A) or PEG-IFNα-2a/RBV (group B). Patients who showed HCV RNA at week 4 but were negative at week 12 were randomly assigned to receive weekly PEG-IFNα-2a (group C) or biweekly therapy (group D). Patients who showed HCV RNA at week 12 but were negative at week 24 were randomly assigned to receive PEG-IFNα-2a/RBV (group E) or PEG-IFNα-2a/RBV/fluvastatin (group F).Results
Overall, the rate of sustained virological response (SVR) was 46 % (70/153). The total SVR rate in the group (A, D, and F) of response-guided therapy was significantly higher than that in the group (B, C, and E) of conventional therapy [70 % (38/54) versus 52 % (32/61), p = 0.049]. Although IL28-B polymorphism and Core 70 mutation were significantly associated with efficacy, patients with rapid virological response (RVR) and complete early virological response (cEVR) achieved high SVR rates regardless of their status of IL-28B polymorphism and Core 70 mutation.Conclusion
In addition to knowing the IL-28B polymorphism and Core 70 mutation status, understanding the likelihood of virological response during treatment is critical in determining the appropriate treatment strategy. 相似文献90.
Hiroki Shimizu Atsushi Shiozaki Daisuke Ichikawa Hitoshi Fujiwara Hirotaka Konishi Hiromichi Ishii Shuhei Komatsu Takeshi Kubota Kazuma Okamoto Mitsuo Kishimoto Eigo Otsuji 《Journal of gastroenterology》2014,49(4):655-666