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81.
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Tomotaka Yazaki Ichiro Moriyama Hiroshi Tobita Hiroki Sonoyama Eiko Okimoto Akihiko Oka Yoshiyuki Mishima Naoki Oshima Kotaro Shibagaki Kousaku Kawashima Norihisa Ishimura Taichi Nagami Riruke Maruyama Hiroaki Shiina Shunji Ishihara 《Internal medicine (Tokyo, Japan)》2022,61(10):1485
Immune checkpoint inhibitors (ICIs), which have anti-tumor effects, are currently approved for treatment of several kinds of advanced malignancies. However, with their increasing use, a variety of immune-related adverse events (irAEs) in administered patients have been reported. We herein report a rare case of the simultaneous onset of acute pancreatitis and colitis as irAEs during nivolumab treatment given to a patient with renal cell carcinoma, who then shown marked improvement with corticosteroid therapy. 相似文献
84.
Runa Emoto Shoichiro Yatsu Takuma Yoshihara Eiryu Sai Tadashi Miyazaki Taira Yamamoto Atsushi Amano Hiroyuki Daida Katsumi Miyauchi 《Internal medicine (Tokyo, Japan)》2022,61(10):1549
Mid-aortic syndrome (MAS) is a rare vascular disorder that causes refractory hypertension. A 76-year-old woman was hospitalized for acute heart failure (HF) with drug-resistant hypertension; other comorbidities included epigastric artery rupture, old myocardial infarction, an intraventricular thrombus, and a cerebral artery aneurysm. Angiography revealed severe narrowing of the descending aorta, which led to the diagnosis of MAS. Although intensive medical treatment improved her HF, optimal blood pressure (BP) could not be achieved. Percutaneous coronary intervention and surgical bypass for diseased aorta was then performed in two stages, resulting in the achievement of optimal BP and alleviation of HF. 相似文献
85.
A virtual reality‐based method of decreasing transmission time of visual feedback for a tele‐operative robotic catheter operating system 下载免费PDF全文
86.
Takeshi Yamashina Ryu Ishihara Noriya Uedo Kengo Nagai Fumi Matsui Natsuko Kawada Takashi Oota Hiromitsu Kanzaki Masao Hanafusa Sachiko Yamamoto Noboru Hanaoka Yoji Takeuchi Koji Higashino Hiroyasu Iishi 《Digestive endoscopy》2012,24(4):220-225
Background and Aim: Limited data are available regarding the use of endoscopic submucosal dissection (ESD) for superficial esophageal cancers ≥50 mm in diameter. The aim of the present study was to investigate the safety and success of ESD for superficial esophageal cancers ≥50 mm. Methods: A total of 39 patients with superficial esophageal squamous cell carcinoma ≥50 mm were treated with ESD at Osaka Medical Center for Cancer and Cardiovascular Diseases between January 2004 and April 2011, and were analyzed in a retrospective study. Results: En bloc resection was achieved in all patients. One mediastinal emphysema without perforation occurred during the procedure. Stricture developed in 11 of 39 patients, requiring a median of five endoscopic balloon dilatation procedures. Thirty‐three clinical epithelial or lamina propria mucosal cancers were treated by ESD with curative intent, of which invasion into the muscularis mucosa or deeper was detected in seven and lymphovascular involvement in three. The en bloc resection rate was 100% with a tumor‐free margin achieved in 92% of lesions. The curative resection and complication rates during ESD were 70% and 2.5%, respectively. Conclusion: ESD achieved a high en bloc resection rate of 92% with a tumor‐free margin. Curative resection rate of ESD in patients with clinical epithelial or lamina propria mucosal cancers was not low at 70%. However, the risk of stricture must be taken into account when considering the use of ESD in lesions ≥50 mm. 相似文献
87.
88.
Acute effects of coronary vasodilators (nifedipine, nicardipine, and nitroglycerin) on atrial natriuretic peptide (ANP) and the renin-angiotensin-aldosterone system were studied in normal subjects and patients with essential hypertension. Nifedipine lowered blood pressure both in normal subjects and in patients and elevated ANP, plasma renin activity, and angiotensin II in normal subjects but not in hypertensive patients. Nicardipine lowered blood pressure but failed to elevate ANP and angiotensin II in normal subjects. Nitroglycerin failed to elevate ANP in normal subjects. 相似文献
89.
Anomalous Junction of Pancreaticobiliary Duct without Congenital Choledochal Cyst: A Possible Risk Factor for Gallbladder Cancer 总被引:13,自引:0,他引:13
Shoichiro Yamauchi M.D. Akitoshi Koga M.D. Shinji Matsumoto M.D. Masao Tanaka M.D. Fumio Nakayama M.D. F.A.C.S. 《The American journal of gastroenterology》1987,82(1):20-24
Among 1586 patients subjected to endoscopic retrograde cholangiopancreatography, an anomalous junction of the pancreaticobiliary duct (AJPB) was found in 24 patients (1.5%). Eighteen of the 24 had an associated congenital choledochal cyst, and six did not. Four of these six patients (66.7%) had gallbladder cancer. A clinicopathological study was performed on these four and 43 such cases reported in the literature. The diagnosis of AJPB was made by direct cholangiography. Median age of these 47 (53.5 yr) was younger than those without AJPB. The length of the common channel ranged from 15 to 53 mm. The pancreatic-biliary type junction was present in 36 of 39 cases (92.3%). Gallstones were present in 7 of 40 (17.5%). Levels of amylase in bile were high in 10 of 11. Presence of AJPB without congenital choledochal cyst may be a high risk factor in gallbladder cancer; hence prophylactic cholecystectomy should be considered for patients with AJPB, without congenital choledochal cyst. 相似文献
90.
A single protein catalyzes both N-deacetylation and N-sulfation during the biosynthesis of heparan sulfate. 总被引:3,自引:0,他引:3 下载免费PDF全文
Z Wei S J Swiedler M Ishihara A Orellana C B Hirschberg 《Proceedings of the National Academy of Sciences of the United States of America》1993,90(9):3885-3888
Heparan sulfate is a highly sulfated carbohydrate polymer that binds to and modulates the activities of numerous proteins. The formation of these protein-binding domains in heparan sulfate is dependent on a series of biosynthetic reactions that modify the polysaccharide backbone; the initiating and rate-limiting steps of this process are the N-deacetylation and N-sulfation of N-acetylglucosamine residues in the polymer. We now report that in the rat liver, biosynthesis of heparan sulfate utilizes a single protein that possesses both N-deacetylase and N-sulfotransferase activities. This was accomplished by demonstrating that both activities resided in a purified soluble fusion protein containing the Golgi-lumenal portion of the enzyme. We propose that this protein be renamed the rat liver Golgi heparan sulfate N-deacetylase/N-sulfotransferase. 相似文献