全文获取类型
收费全文 | 9034篇 |
免费 | 405篇 |
国内免费 | 38篇 |
专业分类
耳鼻咽喉 | 57篇 |
儿科学 | 130篇 |
妇产科学 | 112篇 |
基础医学 | 1108篇 |
口腔科学 | 164篇 |
临床医学 | 607篇 |
内科学 | 2307篇 |
皮肤病学 | 136篇 |
神经病学 | 467篇 |
特种医学 | 433篇 |
外科学 | 1944篇 |
综合类 | 58篇 |
预防医学 | 327篇 |
眼科学 | 110篇 |
药学 | 464篇 |
中国医学 | 17篇 |
肿瘤学 | 1036篇 |
出版年
2023年 | 52篇 |
2022年 | 98篇 |
2021年 | 155篇 |
2020年 | 76篇 |
2019年 | 99篇 |
2018年 | 138篇 |
2017年 | 131篇 |
2016年 | 141篇 |
2015年 | 158篇 |
2014年 | 196篇 |
2013年 | 216篇 |
2012年 | 356篇 |
2011年 | 396篇 |
2010年 | 245篇 |
2009年 | 189篇 |
2008年 | 396篇 |
2007年 | 450篇 |
2006年 | 424篇 |
2005年 | 432篇 |
2004年 | 432篇 |
2003年 | 411篇 |
2002年 | 405篇 |
2001年 | 354篇 |
2000年 | 359篇 |
1999年 | 335篇 |
1998年 | 149篇 |
1997年 | 104篇 |
1996年 | 103篇 |
1995年 | 71篇 |
1994年 | 50篇 |
1993年 | 85篇 |
1992年 | 213篇 |
1991年 | 174篇 |
1990年 | 178篇 |
1989年 | 174篇 |
1988年 | 147篇 |
1987年 | 155篇 |
1986年 | 139篇 |
1985年 | 151篇 |
1984年 | 103篇 |
1983年 | 92篇 |
1982年 | 43篇 |
1979年 | 77篇 |
1978年 | 56篇 |
1977年 | 44篇 |
1974年 | 45篇 |
1973年 | 47篇 |
1971年 | 48篇 |
1968年 | 44篇 |
1967年 | 41篇 |
排序方式: 共有9477条查询结果,搜索用时 15 毫秒
21.
Late Effects of Childhood Acute Leukemia and Its Treatment 总被引:1,自引:0,他引:1
Masao Yamamoto M.D. Yoshitaka Fukunaga M.D. Ichiroh Tsukimoto M.D. Fumio Bessho M.D. Jun-ichi Akatsuka M.D. Ryohta Hosoya M.D. Shinpei Nakazawa M.D. Minoru Sakurai M.D. Kazuhiro Ueda M.D. Sumio Miyazaki M.D. Masaru Yokoyama M.D. Hideo Mugishima M.D. Kohzoh Nishimura M.D. 《Pediatrics international》1991,33(4):573-588
Late effects of childhood acute leukemia and its treatment were studied in 766 patients (684 ALL, 73 ANLL, and 9 others) in Japan who had remained in remission for more than 1 year after their first complete remission. Delayed adverse sequelae involve a wide variety of organs and their functions. Short stature was present in 2.61%, obesity in 3.79%, abnormalities of growth hormone secretion in 1.5%, delayed secondary sex characteristics in 1.5% of males and 0.6% of females, motor disturbances in 1.17%, sensory disturbances in 0.91%, intellectual and learning disabilities in 2.48%, abnormal findings in routine neurologic examinations in 1.31%, EEG abnormalities in 4.30%, brain CT abnormalities in 5.09% and cardiac dysfunction in 1.07%. Various other disorders were seen in 20 patients. Many of these delayed adverse sequelae are caused by or related to central nervous system prophylaxis and systemic combination chemotherapy. The results suggest that it is needed to improve therapeutic methods through the stratification of patients by risk factors and detailed analysis of prognostic factors. Moreover it is important to render medical and psychosocial support to long-term survivors of childhood leukemia through interactions between the patient, parents and medical staff. 相似文献
22.
Osseous xanthomatosis and a pathologic fracture in a patient with hyperlipidemia. A case report 总被引:1,自引:0,他引:1
Osseous xanthomatosis and a pathologic fracture of the femoral neck associated with hyperlipoproteinemia occurred in a 48-year-old woman. Widely distributed skeletal lesions suggested a primary neoplasm such as malignant lymphoma or multiple myeloma; however, needle aspiration cytology of the fracture site, cutaneous manifestations, and abnormally high concentrations of lipoproteins established a diagnosis of intraosseous xanthomatosis associated with hyperlipidemia. Histologically, the excised femoral head showed a dense aggregate of lipid-laden macrophages and depletion of normal bone trabeculae. The hyperlipidemia is classified as Type IIb hyperlipoproteinemia. 相似文献
23.
Shin-ichiro Maruya Hidekachi Kurotaki Ryuichi Wada Takashi Saku Hideichi Shinkawa Soroku Yagihashi 《Modern pathology》2004,17(6):637-645
Adenoid cystic carcinoma, a relatively uncommon tumor of salivary glands, is characterized by a prolonged clinical course and a fatal outcome. The molecular events underlying their progression are unknown. In this study, we examined the methylation status of E-cadherin gene and its protein expression in 23 cases of adenoid cystic carcinoma and correlated the results with the clinicopathologic factors to determine its role in these tumors. We also analyzed the effect of 5-azacytidine on the re-expression in a methylated cell line of adenoid cystic carcinoma for this gene. In our study, E-cadherin immunoreactivity, although heterogeneous, showed a progressive reduction with high histological grade and in metastatic and recurrent lesions. Promoter methylation was detected in 16 of 23 cases (70%), but there was no correlation with the histological grade or patient prognosis. Microdissection of immuno-negative cells in heterogeneous tumors showed positive methlyation. In the cell line from salivary adenoid cystic carcinoma with methylated E-cadherin, 5-azacytidine restored the E-cadherin expression. Our results indicate that: (1) E-cadherin gene promoter is frequently methylated in adenoid cystic carcinoma, leading to reduced E-cadherin expression, (2) variable E-cadherin expression might result from the intratumoral heterogeneity, and (3) increased extent of methylated areas may be associated with progression and advancement of the disease. 相似文献
24.
25.
26.
Blood pressure changes following extracorporeal shock wave lithotripsy for urolithiasis. 总被引:1,自引:0,他引:1
M Yokoyama F Shoji R Yanagizawa M Kanemura K Kitahara S Takahasi K Kawai H Oda M Osaka H Handa 《The Journal of urology》1992,147(3):553-7; discussion 557-8
Hypertension after extracorporeal shock wave lithotripsy (ESWL) has been a controversial subject. Changes in blood pressure were studied in 262 patients (mean age 47.8 years) 18.6 months after ESWL. According to World Health Organization criteria the number of patients who showed a decrease exceeded those who showed an increase in blood pressure. The patients who have been on antihypertensive therapy showed a significantly greater decrease in blood pressure than those without medication. Of 192 normotensive patients diastolic pressure increased 1.2 mm. Hg and 2 (1.0%) had hypertension 18.4 months after ESWL. Annualized increase in diastolic pressure and new onset of hypertension were calculated to be 0.78 mm. Hg and 0.65%, respectively. Significant elevation of diastolic pressure was noted in the patients who received a larger number of shock waves. Blood pressure should be carefully followed after ESWL especially in patients who have been treated by a greater number of shock waves. 相似文献
27.
M S Laskar M H Mahbub Kenjiro Yokoyama Masaiwa Inoue Noriaki Harada 《The European journal of contraception & reproductive health care》2006,11(3):220-227
OBJECTIVE: There might be a difference between non-working and working women in their perception of rights and privileges which may influence their contraceptive behavior. The purpose of this study was to examine contraceptive behavior among non-working and working women in Bangladesh determining associated factors. METHOD: Analysis was based on data from the 1999-2000 Bangladesh Demographic and Health Survey which employs nationally representative sample. RESULTS: The prevalence of current contraceptive use (any method) was 58.2% among non-working women and 65.5% among working women. Both rates are still low for the country. Some factors, such as discussed family planning with husband, husband approves family planning, desire for more children, and husband lives together, were influential determinants of lower contraceptive prevalence among the non-working women. CONCLUSION: The results indicate a necessity for social activities promoting husband-wife communication and women's participation in employment to enhance the use of contraceptives among Bangladeshi women, especially non-working women. 相似文献
28.
Y Fujibayashi Y Takemura K Matsumoto K Wada Y Yonekura J Konishi A Yokoyama 《Journal of nuclear medicine》1992,33(4):545-549
In view of the high binding ability of cardiac glycosides to the myocardial Na,K-ATPase, radioiodinated digoxin derivatives were surveyed as candidates for myocardial imaging, with particular emphasis on the noninvasive monitoring of cardiac glycoside therapy. Among the radioiodinated digoxin derivatives surveyed, 125I-digoxin-iodohistamine(bis(O-carboxymethyloxime)) showed the highest accumulation in the myocardium and similar binding ability to Na,K-ATPase as digoxin itself against ouabain displacement, as indicated by in vivo and in vitro studies. Based on these results, 123I labeling of digoxin-histamine(bis(O-carboxymethyloxime)) and imaging in a dog demonstrated uptake in the myocardium. 相似文献
29.
Amygdaloid-kindled rats received intravenous human copper-zinc superoxide dismutase (CuZn-SOD) either in free form or entrapped within liposomes (SOD-L), at 5, 10 or 20 mg/kg. The animals were stimulated at the generalized seizure-triggering threshold 5 min, 2 h and then every 24 h after the drug was given, until 5 consecutive stage 5 seizures were induced. Free CuZn-SOD had little or no effect. However, SOD-L, particularly at 10 mg/kg, had a prolonged anticonvulsant effect, although there was great individual variation in the onset and duration of seizure suppression. This effect of SOD-L may be due to the ability of liposomes to act as a depot for the sustained release of drugs. 相似文献
30.