病理学教学改革研究——以淋巴造血系统疾病为例

基础病理学教学中，淋巴造血系统疾病一直是难点，鉴于淋巴瘤发病率的逐年增高，教师对该章节的教学能力及教学质量也要更加重视。首都医科大学基础医学院病理学系以该教学难点为突破口，通过基础、临床的融合，整合及加强师资力量；集体备课提高年轻教师教学能力；收集及整理淋巴瘤的教学素材，包括典型病例、典型切片及分子诊断教学平台的搭建；积极开展课程思政融入教学等多种方式，同时多种教学方法联合应用，取得了很好的教学效果。并通过对以上工作及方法的总结，以期在未来的实验课教学、过程性考核、期末考核和线上虚拟教学平台中发挥重要作用，最终达到全面提高本科生基础病理学教学质量的目的。     

对我国多媒体健康教育项目发展的思考与启示

系统分析国外多媒体技术在病人健康教育中的应用研究,总结归纳多媒体项目设计特征与应用效果,以期为我国多媒体健康教育项目成功建设提供一定借鉴。     

Clinicopathological features and expression of four keratins (K10, K14, K17 and K19) in six cases of eruptive vellus hair cysts

Six cases of eruptive vellus hair cysts (EVHC) were evaluated for histopathology and the immunohistochemical profile of Ki‐67 and four keratins (K10, K14, K17 and K19). The pathological hallmark of EVHC was the existence of vellus hair shafts within the cystic cavity, but atypical pathological changes included two or three cysts and a foreign‐body granuloma in three cases. Our results demonstrate that atypical pathological changes are not uncommon in EVHC, and indicate that based on keratin expression, it is likely that EVHC is derived from the infrainfundibulum and sebaceous duct.     

护士主动报告护理不良事件影响因素的研究进展

阐述护士主动报告护理不良事件的现状,影响因素包括管理因素、文化因素、个人因素、工作环境因素,并提出构建以人为本的差错管理模式、营造开放的文化安全屏障,规范不良事件的管理文件,拓宽护理部管理职能、激励员工积极上报,倡导人文关怀、缓解护士压力等对策,为今后持续改进不良事件报告制度,构建高效、畅通、完善、人文化的报告系统提供参考。     

Investigation of Solid Dosage Form Components Interaction Using Orthogonal Techniques- Discovery of New Forms of Sodium Stearyl Fumarate

Physical or chemical interactions between drug product (DP) components can occur during manufacturing and/or upon storage; and may alter DP shelf life and performance. In this work a new Powder X-ray Diffraction (PXRD) peak was observed in DP under accelerated storage conditions. Due to the complex drug product matrix (including API, polymer, fillers, super disintegrant and lubricant), it was challenging to pinpoint the component(s) responsible for the new peak. In addition to PXRD, other orthogonal techniques including Differential Scanning Calorimetry (DSC), thermogravimetric analysis (TGA), dynamic vapor sorption (DVS), Solid State Nuclear Magnetic Resonance (SSNMR) and Infrared (IR) spectroscopy were employed in this investigation to understand the root cause mechanistically. Specifically, multi nuclei SSNMR (¹H, ²³Na, ¹³C) was instrumental in delineating the components of the matrix. We identified the root cause to be an acid base reaction occurring in the DP, whereby sodium ion in sodium stearyl fumarate (SSF) is replaced by proton leading to SSF form conversion. We also identified commercially available SSF to be a hydrate that can dehydrate to an anhydrous form upon heating. In general, the same techniques can be used to investigate interactions of any multi component solid dosage forms.     

新版GMP规范下无菌制剂洗烘灌封联动分装线URS

URS是设备采购的重要技术资料,针对新版GMP规范要求,结合洗烘灌封联动分装线系统及无菌制药工艺特点制定相关URS。