应用白芨建立门静脉高压动物模型

目的寻求制作门静脉高压动物模型的最佳方法，并以此为基础从事肝硬化后门静脉血液动力学基础研究。方法以3组共15只兔为动物模型，分别以0.2％、0．4％、0.8％浓度的白芨粉为栓塞材料，开腹注入兔门静脉内，手术前后行门静脉测压、血管造影及病理学检查，最长观察时间阎周.结果以0．4％浓度白芨粉制作门静脉高压模型最佳，4周后肝脏体积缩小20％，门静脉压平均升高40％，病理呈典型坏死后肝硬化表现。结论以白芨粉为栓塞材料制作肝硬化门静脉高压动物模型方法简单、效果可靠已重复性好.以不同浓度的白芨栓塞剂来控制坏死后肝纤维化的程度是本试验的一大特点,本动物模型的建立对深入研究肝硬化门静脉高压的成因及治疗措施有着重要意义。     

原发性颅内恶性淋巴瘤的CT诊断

原发性颅内恶性淋巴瘤的ＣＴ诊断郭凡樊长姝北京铁路总医院ＣＴ室１０００３８提要对６例经手术病理证实的原发性颅内恶性淋巴瘤的ＣＴ表现进行分析后，认为对发生在中线区表现为均匀高密度，边缘清楚具有分叶征象的病灶，可作为ＣＴ的表现的特点。在放、化疗过程中出现肿...     

Demonstration of a radionuclide pattern in phenochromocytomas in children

Scintigraphic findings in a child with pheochromocytomas is illustrated. The patient demonstrated a hypervascular lesion during the radionuclide angiogram, and renal displacement on subsequent static images.     

Circulating levels of inhibin in cancer

Study on frequency distribution of serum inhibin levels--a peptide hormone involved in suppression of follicle stimulating hormone--was carried out using a specific radioimmunoassay developed in this laboratory, on 237 sera from normal men and women, from male and female patients with cancer prostate, lung, stomach and breast, and from patients with non-malignant disease of the respective organ. The mean serum inhibin levels in patients with malignant and non-malignant disease of prostate (90 +/- 19 ng/ml and 54 +/- 8 ng/ml) were significantly higher than found in normal men (31 +/- 9 ng/ml). However, the levels in cancer of stomach (70 +/- 9 ng/ml) and lung (45 +/- ng/ml) were higher than those in normal as well as benign condition of stomach and lung. The mean serum inhibin in case of women with cancer of breast (27 +/- 5 ng/ml) and lung (53 +/- 16 ng/ml) were significantly higher than those found in normal women (15 +/- 2 ng/ml) and in women with benign disease of breast (10 +/- 3 ng/ml) and lung (21 +/- 4 ng/ml). Considering the levels in individual patient basis, 66% of the patients with cancer of stomach had higher inhibin concentration than the uppermost limit of inhibin found in normal men and in contrast none in benign disease of stomach.     

Effect of muscimol,a central GABA receptor agonist,on the catalepsy,striatal homovanillic acid increase,and analgesia induced by pilocarpine in rats

Muscimol, a structural analog of GABA, significantly potentiated pilocarpine-induced analgesia in rats, but failed to alter pilocarpine-induced catalepsy. It also failed to affect pilocarpine-elicited increase in homovanillic acid levels in the striatum. These findings suggest that the potentiation of pilocarpine-induced analgesia by muscimol is unrelated to an interaction of the GABAergic system with the striatal cholinergic or dopaminergic systems.