Cardioprotective effect of Chinese herbal medicine for anthracycline-induced cardiotoxicity in cancer patients: A meta-analysis of prospective studies

Background:To assess the benefits and harmful effects of Chinese herbal medicine (CHM) formulations in preventing anthracyclines (ANT)-induced cardiotoxicity.Method:The Cochrane Library, Pubmed and EMBASE databases were electronically searched for relevant randomized controlled trials (RCTs) published till December 2021 in English or Chinese-language, in addition to manual searches through the reference lists of the selected papers, and the Chinese Conference Papers Database. Data was extracted by 2 investigators independently.Result:Seventeen RCTs reporting 11 different CHMs were included in this meta-analysis. The use of CHM reduced the occurrence of clinical heart failure (RR 0.48, 95% CI 0.39 to 0.60, P < .01) compared to the control group. Data on subclinical heart failure in terms of LVEF values showed that CHM reduced the occurrence of subclinical heart failure (RR 0.47, 95% CI 0.35 to 0.62, P < .01) as well.Conclusion:CHM is an effective and safe cardioprotective intervention that can potentially prevent ANT-induced cardiotoxicity. However, due to the insufficient quality of the included trials, our results should be interpreted with cautious.     

蝶枕角与颅底诸结构至耳眼平面垂直距离的纵向比较

目的:为人颅底的生长发育研究提供正常的颅底结构测量数据和参照标准;初步分析颅底生长发育趋势和特点。方法:对人不同生长发育阶段颅底标本诸结构进行观察和测量,并对其进行相互比较和纵向分析。结果:颅底在不同发育阶段各有其趋势和特点,蝶枕角随着年龄的增长逐渐变小,但性别之间无差异,颅前窝诸结构变化幅度最大,颅中窝的变化相对最小,11项测量指标在不同生长发育阶段的变化各异。结论:观察测量数据可为人颅底生长发育进一步研究提供依据,蝶枕角、耳眼(FH)平面可作为颅底生长发育的观察测量指标和参照平面。     

Regularized sensitivity encoding (SENSE) reconstruction using bregman iterations

In parallel imaging, the signal‐to‐noise ratio (SNR) of sensitivity encoding (SENSE) reconstruction is usually degraded by the ill‐conditioning problem, which becomes especially serious at large acceleration factors. Existing regularization methods have been shown to alleviate the problem. However, they usually suffer from image artifacts at high acceleration factors due to the large data inconsistency resulting from heavy regularization. In this paper, we propose Bregman iteration for SENSE regularization. Unlike the existing regularization methods where the regularization function is fixed, the method adaptively updates the regularization function using the Bregman distance at different iterations, such that the iteration gradually removes the aliasing artifacts and recovers fine structures before the noise finally comes back. With a discrepancy principle as the stopping criterion, our results demonstrate that the reconstructed image using Bregman iteration preserves both sharp edges lost in Tikhonov regularization and fines structures missed in total variation (TV) regularization, while reducing more noise and aliasing artifacts. Magn Reson Med 61:145–152, 2009. © 2008 Wiley‐Liss, Inc.     

β-FIBRINOGEN PROMOTER-455 G／A （HaeⅢ） POLYMORPHISM PREDICTION OF PLASMA FIBRINOGEN BUT NOT OF ISCHEMIC CEREBROVASCULAR DISEASE

Objective The-455 G/A (HaeⅢ) polymorphism of β-fibrinogen gene influences levels of plasma fibrinogen. We further investigated whether it influences the risk of isehemie cerebrovaseular disease. Methods We accumulated 134 acute isehemic eerebrovaseular disease (ICVD) eases and compared their -455 G/A status with a control group (n=166). The β-fibrinogen gene -455 G/A polymorphism was analyzed for all subjects by PCR-RFLP with the restrictive enzyme HaeⅢ. Results Plasma fibrinogen was higher in AA homozygous participants (341mg/dL) than in participants carrying the G allele: GA (290mg/dL), GG (298mg/dL) in the control group. Plasma fibrinogen was also higher in AA homozygous patients (353mg/dL) than in eases carrying the G allele: GA (287mg/dL), GG (302mg/dL) in the ICVD group. However, there was no significant association between β-fibrinogen gene -455 G/A polymorphism and ICVD group. Conclusions Although a small effect cannot be excluded, β-fibrinogen gene -455 G/A polymorphism is an independent predictor of plasma fibrinogen, but not of isehemie cerebrovaacular disease.     

头皮肿瘤切除后的修复(附27例报告)

本文报道27例头皮肿瘤手术切除和修复的经验。作者指出;头皮恶性肿瘤切除范围至少要距肿瘤边缘1.5～2.5cm,切除的深度要比肿瘤所侵润的组织深1～2个层次。对肿瘤切除后所致头皮缺损的修复,应根据头皮缺损的范围和深度,分别应用局部头皮辨;游离植皮;局部皮瓣和游离植皮相结合;身体其它部位皮瓣移植等方法。对于颅骨缺损,作者不主张即刻修复。     

人发角蛋白人工腱肌肉植入的组织相容性观察

为了研究人发角蛋白人工腱（human hair keratin artifical tendon,HHKAT）材料在体内的降解及其对周围组织的影响，将12只日本大耳白兔随机分组，在脊旁肌埋藏不同处理程度的人发角蛋白人工腱度件F及Z，用正常人发O做对照，分别在2，6，12，24周取材，观察人发角蛋白的降解及其周围的组织反应，结果：实验中发现不同程度处理的HHKAT其降解速度不同，其中降解最快的F组在24周时已完全吸收，而Z组在24周时只有部分降解，O组未见降解，HHKAT及人发在肌肉组织内无明显的炎症排斥反应，随着HHKAT材料的降解吸收，其周围的组织反应逐渐降低，研究表明人发角蛋白人腱材料具有良好的生物相容性，在体内能够被降解吸收，可根据不同的需要调节其降解速度，是良好肌腱替代材料。     

双钢板垂直和平行放置治疗C型肱骨远端骨折的对比研究

Background Double plate osteosynthesis is the standard treatment for intra-articular fractures of the distal humerus. However, there is still controversy concerning dual plate positions in terms of providing optimal stability. The purpose of this retrospective study was to compare the clinical outcomes in patients with type C intra-articular distal humeral fractures using perpendicular and parallel plating methods.

Methods Between March 2008 and June 2011, a total of 45 patients with type C distal humerus fractures were treated using two different dual plating methods. Of them, 24 patients were treated by perpendicular plating (group I) and 21 patients were treated by parallel plating (group II). The surgical time, blood loss, and union time were compared between the two groups. The flexion-extension arc, the total range of flexion and extension at the end of follow-up were compared between the two groups. The Mayo Elbow Performance Score (MEPS) was used to determine the elbow functional results.

Results All patients were followed up. The mean duration of follow-up was 16 months (range 12–25 months) in group I and 15.5 months in group II (range 12–25 months). There were no significant differences in the surgical time, blood loss, and the bone union time between the two groups. In group I, the mean elbow flexion-extension arc was 101° and the mean MEPS was 85 points. The rate of excellent and good results was 87.5%. In group II, the mean flexion-extension arc was 100° and the mean MEPS was 86.1 points. The rate of excellent and good results was 90.5%. There were no significant differences in the MEPS, flexion-extension arc, and the total range of flexion and extension between the two groups.

Conclusions Perpendicular and parallel plate configurations with the appropriate surgical techniques can provide anatomical reconstruction and stable fixation of type C intra-articular distal humeral fractures and allow early mobilization of the elbow after an operation. The occurrence of post-operative elbow stiffness can be reduced and good outcomes can be obtained.

     

孤立性心室肌致密化不全一例报告

1 临床资料患者,男,56岁,因反复发作的胸闷、气短于2002年入院,患者缘于2000年2月出现劳力时胸闷、气短,未经治疗,此后上述症状反复发作,于2002年10月上述症状加重,休息时也有胸闷、气短症状,逐渐出现夜间阵发性呼吸困难和端坐呼吸,于当地医院诊断为扩张型心肌病,经治疗无明显好转后转院入我科.入院后给予强心、利尿、扩血管等药物治疗,患者胸闷、气短症状曾一度好转,心电图提示心房纤颤,二维超声心动图可在左室心尖部、前侧壁心内膜面探及多发性突入左室腔内的肌小梁,小梁之间可见深度不同的间隙.