全文获取类型
收费全文 | 1134篇 |
免费 | 52篇 |
国内免费 | 8篇 |
专业分类
儿科学 | 30篇 |
妇产科学 | 25篇 |
基础医学 | 123篇 |
口腔科学 | 6篇 |
临床医学 | 149篇 |
内科学 | 208篇 |
皮肤病学 | 26篇 |
神经病学 | 135篇 |
特种医学 | 26篇 |
外科学 | 248篇 |
综合类 | 9篇 |
预防医学 | 82篇 |
眼科学 | 9篇 |
药学 | 57篇 |
肿瘤学 | 61篇 |
出版年
2023年 | 8篇 |
2022年 | 23篇 |
2021年 | 46篇 |
2020年 | 16篇 |
2019年 | 26篇 |
2018年 | 40篇 |
2017年 | 25篇 |
2016年 | 30篇 |
2015年 | 43篇 |
2014年 | 46篇 |
2013年 | 48篇 |
2012年 | 73篇 |
2011年 | 83篇 |
2010年 | 40篇 |
2009年 | 35篇 |
2008年 | 61篇 |
2007年 | 72篇 |
2006年 | 75篇 |
2005年 | 53篇 |
2004年 | 69篇 |
2003年 | 43篇 |
2002年 | 47篇 |
2001年 | 13篇 |
2000年 | 16篇 |
1999年 | 12篇 |
1998年 | 10篇 |
1996年 | 4篇 |
1992年 | 5篇 |
1991年 | 4篇 |
1990年 | 4篇 |
1989年 | 3篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1984年 | 8篇 |
1983年 | 8篇 |
1981年 | 4篇 |
1980年 | 6篇 |
1979年 | 7篇 |
1978年 | 4篇 |
1977年 | 10篇 |
1976年 | 13篇 |
1975年 | 6篇 |
1974年 | 7篇 |
1973年 | 4篇 |
1970年 | 5篇 |
1969年 | 4篇 |
1968年 | 3篇 |
1967年 | 2篇 |
1966年 | 2篇 |
1965年 | 2篇 |
排序方式: 共有1194条查询结果,搜索用时 15 毫秒
61.
Shapiro SL Bootzin RR Figueredo AJ Lopez AM Schwartz GE 《Journal of psychosomatic research》2003,54(1):85-91
OBJECTIVE: The diagnosis of breast cancer, the most common type of cancer among American women, elicits greater distress than any other diagnosis regardless of prognosis. Therefore, the present study examined the efficacy of a stress reduction intervention for women with breast cancer. METHODS: As part of a larger, randomized, controlled study of the effects on measures of stress of a mindfulness-based stress reduction (MBSR) intervention for women with breast cancer, the current analyses examined the effects on sleep complaints. RESULTS: Analyses of the data indicated that both MBSR and a free choice (FC) control condition produced significant improvement on daily diary sleep quality measures though neither showed significant improvement on sleep-efficiency. Participants in the MBSR who reported greater mindfulness practice improved significantly more on the sleep quality measure most strongly associated with distress. CONCLUSION: MBSR appears to be a promising intervention to improve the quality of sleep in woman with breast cancer whose sleep complaints are due to stress. 相似文献
62.
63.
64.
65.
66.
67.
This report describes a unique case of spontaneous esophageal perforation (Boerhaave's syndrome) presenting as meningitis. After a delay in diagnosis (16 days), the patient was successfully treated with debridement, primary closure, and drainage. Although rare, central nervous system infections have been reported in association with esophageal perforation caused by instrumentation, trauma, and malignancy. We report this case of spontaneous esophageal perforation giving rise to meningitis. 相似文献
68.
69.
70.
Müerköster S Weigand MA Choi C Walczak H Schirrmacher V Umansky V 《British journal of cancer》2002,86(5):828-836
The endogenous viral superantigen 7 in DBA/2 mice serves as a target antigen on syngeneic ESb-MP lymphoma cells for allogeneic graft-vs-leukaemia reactive cells. Allogeneic viral superantigen 7 reactive Vbeta6+ T cells are able to transfer graft-vs-leukaemia reactivity and to kill specifically viral superantigen 7+ ESb-MP tumour cells in vitro. Here we elucidate the mechanism of this superantigen specific cell lysis. Already 10 min after co-incubation with in vitro stimulated Vbeta6+ T cells, viral superantigen 7+ ESb-MP tumour cells show an apoptotic phenotype (Annexin V-positivity, DNA-fragmentation). This extremely rapid type of cell death is not mediated by the death inducing ligands CD95L, TRAIL and TNF but by perforin and granzyme B. Surprisingly, neither mitochondria nor any of the known caspases appear to be involved in this type of tumour cell killing. In contrast, nitric oxide, released by activated macrophages and endothelial cells, induces in the same tumour cells another type of apoptosis which is much slower and involves mitochondria and caspase activation. A synergistic effect between the two different effector mechanisms of superantigen reactive donor cytotoxic T lymphocytes and nitric oxide releasing host macrophages and endothelial cells might explain the effective immune rejection of even advanced metastasised cancer in this graft-vs-leukaemia animal model. 相似文献