慢性肾脏病非透析患者脑钠素与动脉粥样硬化及心功能的关系

目的 研究脑钠素（BNP）与慢性肾脏病（CKD）非透析患者动脉粥样硬化及心功能不全的关系。 方法 采用双抗夹心免疫荧光法检测203例CKD非透析患者与16例高血压患者对照组全血BNP水平，分析其与颈动脉超声结果、心脏彩超结果及既往心血管疾病史的关系。 结果 CKD非透析患者BNP水平与对照组相比显著升高[M（范围）：54.40(15.10～ 173.00) ng/L比9.35(7.35～15.00) ng/L，P < 0.01]。Spearman相关分析显示CKD患者BNP与颈动脉内膜中层厚度（IMT）、左室心肌重量指数（LVMI）等呈正相关。存在颈动脉斑块、左室肥厚或既往发生过心血管事件的患者血BNP水平显著增高。多元回归分析显示LVMI、既往心血管事件均是影响BNP水平的独立因素。 结论 CKD非透析患者BNP水平和动脉粥样硬化性疾病、左室肥厚及心功能不全相关，提示BNP水平可作为一项评价CKD非透析患者心功能及动脉粥样硬化的敏感生物学指标。     

喉咽癌手术放疗后甲状腺功能减退

本文对４２例喉咽癌手术及放疗后患者甲状腺功能的变化的初步探讨表明：在治疗结束后不同时间内有５７．１％的患者Ｔ４降低及（或）ＴＳＨ升高，其中放疗结合甲状腺部分切除者其发生率高达７３．９％，而未行甲状腺部分切除者仅３８．５％，两者呈显著差异（Ｐ＝０．０３）。术前或术后放疗对甲状腺功能影响较小，亦无明显差异。发生时间在治疗结束后２年内尤其在１年左右为多见。     

经直肠超声引导下经会阴125I粒子永久植入治疗前列腺癌的初步经验

目的探讨经直肠超声引导下经会阴125I粒子永久植入治疗前列腺癌的疗效和并发症。方法本组前列腺癌患者5例。年龄61￣83岁,平均70.4岁。临床分期T2bN0M0者2例,T3aN0M0者3例。Gleason评分6分者2例,7分者1例,8分者2例。术前前列腺特异性抗原(PSA)4.5￣17.5ng/ml。T3a期患者植入治疗前先行内分泌治疗。术前制定治疗计划,经直肠超声引导下经会阴125I粒子永久植入操作。术后观察PSA水平变化,连续3次PSA升高即为生化复发,观察术后尿路和直肠并发症发生情况。结果5例患者均术后恢复顺利。术后随访18个月,PSA均明显下降,PSA为0.1ng/ml者3例,0.01ng/ml者1例,0.04ng/m1者1例。5例患者术后均出现不同程度的尿路刺激症状,但6个月后逐渐好转。4例术后出现排便次数增多,术后3个月均好转。未发现尿失禁、直肠溃疡等并发症。结论经直肠超声引导下经会阴125I粒子永久植入治疗前列腺癌的疗效确切,创伤较小。     

抗白色念珠菌鸡卵黄抗体(IgY)的研制

目的：观察鸡蛋黄中抗体的产量、纯度、来源及稳定性。方法：应用白色念珠菌作为抗原免疫25周龄Leghorn鸡，通过改良水溶法（WD）提取蛋黄中抗体IgY，双紫外光测定抗体含量，SDS-APGE电泳检测抗体纯度，Western blot免疫印迹法测定该抗体来源，ELISA检测热处理后的抗体活性。结果：抗体含量13mg/ml蛋黄液，抗体纯度达到95%，Western blot免疫印迹证明该抗体与鸡血清中的IgG具有相同的分子量和抗原性。ELISA检测热处理后的抗体活性，其具有良好的热稳定性。结论：鸡蛋黄内含有丰富的抗体，通过WD水溶提取法可得到高产量，高纯度的特异性抗体IgY，证明其来源于鸡血清中的IgG，对热具有高度稳定性。     

角膜移植术护理探讨

以１５例角膜移植术的护理实践，总结出该手术的护理常规，并对本组病例中发生的并发症的护理进行了讨论，强调护士密切观察病情，有效地处理并嫌下对手术成功的重要性。     

基于MATLAB胎儿心电实时显示

文章介绍了从母亲体中采集到的心电信号，利用MATLAB软件对采集到的心电信号进行准确的数据实时处理，分离出胎儿心电（ECG）信号，实验结果表明，这种方法有一定的实用性。     

Attitudes towards mental illness: testing the contact hypothesis among Chinese student nurses in Hong Kong

This study investigated whether previous contact with mental illness affected the attitudes to mental illness (AMI) of general student nurses in Hong Kong — the contact hypothesis. We employed a quasi-experimental design. We compared the attitudes to mental illness of students who had previous contact with mental illness through having taken a psychiatric secondment with those who had not taken a psychiatric secondment. Also, we compared the AMI of: students who had taken other courses related to mental illness with those who had not; those who had a family history of mental illness with those who had not; and those who lived with a mentally ill relative with those who did not. We found that previous contact with mental illness had no significant effect on the attitudes to mental illness of the students. In other words our findings do not support the contact hypothesis. Our sample expressed positive general attitudes to mental illness when presented with general issues about mental illness. However, their attitudes were less positive when presented with specific issues about mental illness that might impinge upon their daily lives. We discuss the implications of these findings for mental health nursing practice, education and research.