全文获取类型
收费全文 | 788篇 |
免费 | 40篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 21篇 |
妇产科学 | 18篇 |
基础医学 | 67篇 |
口腔科学 | 20篇 |
临床医学 | 64篇 |
内科学 | 228篇 |
皮肤病学 | 33篇 |
神经病学 | 35篇 |
特种医学 | 13篇 |
外科学 | 99篇 |
综合类 | 17篇 |
预防医学 | 32篇 |
眼科学 | 6篇 |
药学 | 71篇 |
中国医学 | 1篇 |
肿瘤学 | 91篇 |
出版年
2023年 | 10篇 |
2022年 | 24篇 |
2021年 | 18篇 |
2020年 | 12篇 |
2019年 | 20篇 |
2018年 | 30篇 |
2017年 | 13篇 |
2016年 | 20篇 |
2015年 | 14篇 |
2014年 | 29篇 |
2013年 | 39篇 |
2012年 | 58篇 |
2011年 | 55篇 |
2010年 | 26篇 |
2009年 | 28篇 |
2008年 | 31篇 |
2007年 | 41篇 |
2006年 | 42篇 |
2005年 | 41篇 |
2004年 | 46篇 |
2003年 | 27篇 |
2002年 | 36篇 |
2001年 | 20篇 |
2000年 | 18篇 |
1999年 | 12篇 |
1998年 | 10篇 |
1997年 | 4篇 |
1996年 | 3篇 |
1995年 | 4篇 |
1994年 | 7篇 |
1993年 | 6篇 |
1992年 | 11篇 |
1991年 | 8篇 |
1990年 | 6篇 |
1989年 | 7篇 |
1988年 | 4篇 |
1987年 | 2篇 |
1986年 | 3篇 |
1985年 | 2篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1979年 | 3篇 |
1976年 | 5篇 |
1974年 | 7篇 |
1973年 | 6篇 |
1972年 | 2篇 |
1970年 | 2篇 |
1969年 | 2篇 |
1966年 | 5篇 |
1929年 | 1篇 |
排序方式: 共有833条查询结果,搜索用时 15 毫秒
61.
Evaluation of a new radioimmunoassay for urinary albumin 总被引:1,自引:0,他引:1
We have evaluated a new commercially available radioimmunoassay kit for albumin determination in urine. The assay is precise; within-run precision (CV) in the clinically significant ranges is 1.8-3.5%, between-run, 1.2-8.5%. The minimum detection limit was 0.6 micrograms/ml. Analytic recovery of different concentrations of albumin added to urine ranged from 98% to 103%. Samples, stored in plastic containers, were stable at room temperature for periods up to 7 days. Mean albumin excretion rates, measured in 20 normal volunteers for 3-h and 24-h periods during the same day were similar (7.1 +/- 4.6 [SD] versus 6.5 +/- 5.0 micrograms/min). In 8 normal subjects, 3-h excretion rates measured daily for 5 days showed no significant variability. In eight insulin-dependent diabetic subjects, albumin excretion measured in short periods of urine collection (3 h) were also in close agreement with 24-h collections (24.7 +/- 28.9 versus 17.6 +/- 18 micrograms/min). From these results it appears that this commercially available kit is suitable for conveniently monitoring microalbuminuria in large numbers of patients in research studies as well as for office practice. Such widespread use should make it possible to better determine the clinical usefulness of this test in the management of diabetic patients. 相似文献
62.
A. Miranda A. Mickle B. Medda Z. Zhang R.J. Phillips N. Tipnis T.L. Powley R. Shaker J.N. Sengupta 《Neuroscience》2009
Background and aims: Several types of gastric surgeries have been associated with early satiety, dyspepsia and food intolerances. We aimed to examine alterations in gastric vagal afferents following gastric surgery–fundus ligation. 相似文献
63.
Al Wakeel JS Shaheen FA Mathew MC Abouzeinab HM Al Alfi A Tarif NM Al Mousawi MS Mahmoud TS Alorrayed AS Fagir EA Dham RS Shaker DS 《Transplantation proceedings》2008,40(7):2252-2257
We tested a hypothesized pharmacokinetic difference between the reference (Sandimmun Neoral) and test (Sigmasporin Microral) products to prove therapeutic equivalence in an open, multiple fixed dose, one-way crossover, multicenter, and multinational study over a period of 29 days. Forty two stable renal transplant recipients maintained on Sandimmun Neoral were enrolled. Whole blood was collected at day 14 of the study at 0, 0.5, 1.0, 1.5, 2, 3, 4, 5, 6, 8, 10, and 12 hours after reference dosing and the same schedule was repeated at day 29 after switching on an mg:mg basis to the test product at day 15 of the study. Analysis of variance was performed for the pharmacokinetic parameters (area under the curve [AUC](0-12), maximum concentration [C(max)]) of cyclosporine using log-transformed values. Tolerability was assessed by vital signs, adverse events, and laboratory investigations. The 90% confidence interval (CI) test for the Ln-transformed, pharmacokinetic parameters was all within the US Food and Drug Administration acceptable range of 80% to 125%, as Ln area under the steady-state curve (AUC(ss)) was within the range of 92.56 to 103.55 and Ln C(max) was within the range of 85.73 to 103.58; the same also applied for AUC(0-4), which may be considered the area of greatest inter- and intra-patient variability. Furthermore, in line with the newly adopted recommendations of the Expert Advisory Committee on Bioavailability and Bioequivalence of Health Canada, the 90% CI for AUC(ss) was within the narrow range of 90% to 112%. No significant difference in tolerability was recorded between the two products. Sigmasporin Microral (Julphar) was found to be bioequivalent and clinically interchangeable on an mg:mg basis with Sandimmun Neoral (Novartis). 相似文献
64.
Abstract A 34-year-old Marfan patient at the seventh week of pregnancy presented with acute type A aortic dissection and severe aortic regurgitation. The aortic valve and ascending aorta were replaced successfully using circulatory arrest and deep hypothermia. At 35 weeks of gestation, the patient underwent a cesarean section and delivered a healthy baby. To our knowledge, this case is the first to report a favorable fetal outcome following surgical repair of acute dissection in the first trimester of pregnancy. 相似文献
65.
Jatoi A Dakhil SR Nguyen PL Sloan JA Kugler JW Rowland KM Soori GS Wender DB Fitch TR Novotny PJ Loprinzi CL 《Cancer》2007,110(6):1396-1403
BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is a putative mediator of the cancer anorexia/weight loss syndrome. The current study was designed to determine whether etanercept (a dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75-kilodalton TNF receptor linked to the Fc portion of human immunoglobulin [Ig] G1) could palliate this syndrome. METHODS: A total of 63 evaluable patients were randomly assigned to receive either etanercept at a dose of 25 mg subcutaneously twice weekly versus a comparably administered placebo. All patients had an incurable malignancy, acknowledged loss of weight and/or appetite as a concern, and reported a weight loss of >2.27 kg over 2 months and/or a daily intake of <20 calories/kg body weight. RESULTS: Over time, weight gain was found to be minimal in both treatment arms; no patient gained >or=10% of their baseline weight. Previously validated appetite questionnaires revealed negligible improvements in both treatment arms. The median survival was also comparable (175 days vs 148 days in etanercept-treated and placebo-exposed patients, respectively; P = .82). Finally, preliminary data regarding adverse events demonstrated that patients treated with etanercept had higher rates of neurotoxicity (29% vs 0%) but lower rates of anemia (0% vs 19%) and thrombocytopenia (0% vs 14%). Infection rates were negligible in both groups. Genotyping for TNF-alpha-238 and TNF-alpha-308 polymorphisms revealed no clinical significance for these genotypes, except for a preliminary association between presence of the -238 G/A genotype and relatively less favorable survival. CONCLUSIONS: Etanercept, as prescribed in the current trial, does not appear to palliate the cancer anorexia/weight loss syndrome in patients with advanced disease. 相似文献
66.
67.
Melissa E Cloonan Marianne DiNapoli Shaker A Mousa 《Blood coagulation & fibrinolysis》2007,18(4):341-345
The efficacy of anticoagulants, low-molecular-weight heparins (LMWHs), the antiplatelet glycoprotein IIb/IIIa antagonist, or combinations on cancer-activated thrombosis was determined using thromboelastography. The LMWHs tinzaparin and enoxaparin (0.179, 1.79, 17.9 microg) were incubated in human citrated whole blood (n = 4) and then activated by calcium chloride (11 mmol/l) or Colo205 (cell count 10). Concentrations of 9.9, 17.9 and 179 microg glycoprotein IIb/IIIa antagonist, XV454, and combinations with each LMWH were carried out and activated under the same conditions. The experiment was repeated with tissue factor substituting for the Colo205 to induce platelet/fibrin clot formation. Parameters tested in the thrombelastography analysis included clotting time, rate of clot formation due to fibrin formation, clot kinetics, and clot strength related to platelet count (maximum amplitude). Tinzaparin (1.79 microg), enoxaparin (1.79 microg), and XV454 (17.9 microg) significantly reduced the angle by 64, 26 and 27%, respectively, in cancer-induced clotting. Significant reductions in the maximum amplitude occurred in tinzaparin 1.79 microg (31%), enoxaparin 1.79 microg (11%), and XV454 17.9 microg (59%). An overall antithrombotic additive effect occurred when each LMWH (1.79 microg) was combined with XV454 (17.9 microg). The results between cancer-activated and tissue factor-activated blood were similar. The study concludes that an additive effect is present between LMWHs and a glycoprotein IIb/IIIa antagonist in reducing cancer-mediated thrombosis. 相似文献
68.
Preliminary evidence on the efficacy of endoscopically performed interventional techniques for treatment of gastroesophageal
reflux disease has emerged in the last year. Three different techniques—radio frequency-induced thermal injury to the gastroesophageal
junction, endoscopic plication of gastric folds, and endoscopic implantation of inert polymers into the gastroesophageal junction—have
shown promising short-term results. In this review we describe and critically appraise the available published evidence on
the efficacy and safety of these techniques. In addition, we discuss clinical and physiologic aspects that are essential for
their evaluation and comparison. The need for well-designed controlled clinical trials that assess the long-term efficacy
and safety in a wider spectrum of patients is evident, and hopefully such trials are forthcoming. Operator experience and
continued evolution in these techniques are likely to be important determinants. 相似文献
69.
Petersdorf SH Rankin C Head DR Terebelo HR Willman CL Balcerzak SP Karnad AB Dakhil SR Appelbaum FR 《American journal of hematology》2007,82(12):1056-1062
Induction therapy for acute myeloid leukemia (AML) usually consists of 7 days of cytarabine at 100-200 mg/m(2)/day and an anthracycline. Such combinations produce complete response (CR) rates of 60-80% in patients with de novo AML. On the basis of a previous report, suggesting a higher CR rate using a regimen of standard daunomycin and cytarabine followed by 3 days of high-dose cytarabine (HDAC), 101 eligible patients received this regimen in a phase II trial. Sixty patients [59%, 95% confidence interval (CI) 49-69%] achieved a CR, and 10 patients died of infection during induction. Although cytogenetic risk group affected overall survival (P = 0.0016) and relapse-free survival (P = 0.0043), it had no impact on CR rate (P = 0.63). Patients received postremission therapy with repetitive courses of alternate day high-dose cytarabine; this was associated with considerable toxicity and the majority of patients could not receive all of the scheduled postremission therapy. The estimated median survival was 23 months (95% CI 15-34 months), and the estimated probability of surviving 5 years was 34% (95% CI 24-43%). The results of this intensive induction regimen were similar to that seen in previous trials and were not as promising as reported in the previous pilot study. 相似文献
70.
Opinion statement
相似文献
– | Oropharyngeal dysphagia (OPD) develops when a large number of local and systemic causes lead to abnormal oropharyngeal bolus transport and/or compromise of airway safety. |
– | Only a minority of cases of OPD are amenable to curative therapy. |
– | Rehabilitation of swallowing function is the cornerstone of therapy for the overwhelming majority of patients. |
– | Optimal management of oropharyngeal dysphagia requires a multidisciplinary approach involving a gastroenterologist, swallow/therapist, ENT physician, and rehabilitation and nutrition professionals, along with the support of family members. |
– | Therapy of OPD is directed at improvement of oropharyngeal bolus transport, ensuring adequate airway safety, and enhancing overall quality of life. |
– | A better understanding of the pathophysiologic basis of OPD has resulted in more efficacious therapy. However, given the large social and economic impact of OPD, continuing research is needed for development of better diagnostic and therapeutic modalities. |