全文获取类型
收费全文 | 21556篇 |
免费 | 1373篇 |
国内免费 | 63篇 |
专业分类
耳鼻咽喉 | 344篇 |
儿科学 | 1210篇 |
妇产科学 | 538篇 |
基础医学 | 1904篇 |
口腔科学 | 403篇 |
临床医学 | 1677篇 |
内科学 | 5120篇 |
皮肤病学 | 352篇 |
神经病学 | 1099篇 |
特种医学 | 758篇 |
外国民族医学 | 2篇 |
外科学 | 3840篇 |
综合类 | 484篇 |
一般理论 | 3篇 |
预防医学 | 1233篇 |
眼科学 | 922篇 |
药学 | 1628篇 |
1篇 | |
中国医学 | 82篇 |
肿瘤学 | 1392篇 |
出版年
2023年 | 159篇 |
2022年 | 305篇 |
2021年 | 817篇 |
2020年 | 429篇 |
2019年 | 642篇 |
2018年 | 763篇 |
2017年 | 521篇 |
2016年 | 549篇 |
2015年 | 549篇 |
2014年 | 845篇 |
2013年 | 1053篇 |
2012年 | 1567篇 |
2011年 | 1424篇 |
2010年 | 898篇 |
2009年 | 689篇 |
2008年 | 1047篇 |
2007年 | 1071篇 |
2006年 | 1008篇 |
2005年 | 924篇 |
2004年 | 850篇 |
2003年 | 718篇 |
2002年 | 642篇 |
2001年 | 509篇 |
2000年 | 537篇 |
1999年 | 425篇 |
1998年 | 171篇 |
1997年 | 146篇 |
1996年 | 121篇 |
1995年 | 123篇 |
1994年 | 116篇 |
1993年 | 90篇 |
1992年 | 291篇 |
1991年 | 261篇 |
1990年 | 232篇 |
1989年 | 231篇 |
1988年 | 185篇 |
1987年 | 189篇 |
1986年 | 166篇 |
1985年 | 174篇 |
1984年 | 154篇 |
1983年 | 147篇 |
1982年 | 66篇 |
1981年 | 76篇 |
1979年 | 118篇 |
1978年 | 86篇 |
1977年 | 63篇 |
1974年 | 79篇 |
1973年 | 110篇 |
1972年 | 101篇 |
1971年 | 70篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
131.
Chitti R. Moorthy J. Rao Nibhanupudy Ebrahim Ashayeri Alfred L. Goldson Maria C. Espinoza Joseph J. Nidiry Oswald G. Warner Vincent J. Roux 《Journal of the National Medical Association》1982,74(3):261-266
The objective of radiotherapeutic management in esophageal cancer is to accomplish maximum tumor sterilization with minimal normal tissue damage. This sincere effort is most often countered by the differential in tumor dose response vs normal tissue tolerance. Intraluminal isotope radiation, with its inherent advantage of rapid dose falloff, spares the lungs, the spinal cord, and other vital structures, yet yields adequately high doses to esophageal tumor. Though in existence since the turn of the century, the method of intracavitary radium bougie application dropped out of favor due to technical difficulties imposed by the size of the radium source and radiation exposure to the personnel involved. The authors describe a simple “iridium 192 afterloading intraluminal technique” that eliminates technical problems and reduces radiation exposure considerably. 相似文献
132.
Pathogenic potential of environmental Vibrio cholerae strains carrying genetic variants of the toxin-coregulated pilus pathogenicity island 总被引:5,自引:0,他引:5 下载免费PDF全文
Faruque SM Kamruzzaman M Meraj IM Chowdhury N Nair GB Sack RB Colwell RR Sack DA 《Infection and immunity》2003,71(2):1020-1025
The major virulence factors of toxigenic Vibrio cholerae are cholera toxin (CT), which is encoded by a lysogenic bacteriophage (CTXPhi), and toxin-coregulated pilus (TCP), an essential colonization factor which is also the receptor for CTXPhi. The genes for the biosynthesis of TCP are part of a larger genetic element known as the TCP pathogenicity island. To assess their pathogenic potential, we analyzed environmental strains of V. cholerae carrying genetic variants of the TCP pathogenicity island for colonization of infant mice, susceptibility to CTXPhi, and diarrheagenicity in adult rabbits. Analysis of 14 environmental strains, including 3 strains carrying a new allele of the tcpA gene, 9 strains carrying a new allele of the toxT gene, and 2 strains carrying conventional tcpA and toxT genes, showed that all strains colonized infant mice with various efficiencies in competition with a control El Tor biotype strain of V. cholerae O1. Five of the 14 strains were susceptible to CTXPhi, and these transductants produced CT and caused diarrhea in adult rabbits. These results suggested that the new alleles of the tcpA and toxT genes found in environmental strains of V. cholerae encode biologically active gene products. Detection of functional homologs of the TCP island genes in environmental strains may have implications for understanding the origin and evolution of virulence genes of V. cholerae. 相似文献
133.
Anjali Ramaswamy Nina N. Brodsky Tomokazu S. Sumida Michela Comi Hiromitsu Asashima Kenneth B. Hoehn Ningshan Li Yunqing Liu Aagam Shah Neal G. Ravindra Jason Bishai Alamzeb Khan William Lau Brian Sellers Neha Bansal Pamela Guerrerio Avraham Unterman Victoria Habet Carrie L. Lucas 《Immunity》2021,54(5):1083-1095.e7
134.
McNeilly MD Robinson EL Anderson NB Pieper CF Shah A Toth PS Martin P Jackson D Saulter TD White C Kuchibatla M Collado SM Gerin W 《International journal of behavioral medicine》1995,2(4):321-338
It has been speculated that exposure to the chronic stress of racism contributes to the high rates of hypertension among African Americans. Social support may buffer the effects of stress on cardiovascular (CV) health by attenuating stress-induced CV responses that have been linked to hypertension. In this study we investigated the effects of racism and social support on CV reactivity in African American women. Participants showed greater increases in CV and emotional responses while responding and listening to racist provocation. Augmented blood pressure (BP) persisted through recovery following racial stress. Participants receiving no support showed the greatest increases in anger during racist provocation. No significant effects were seen for support on CV reactivity. These results provide some of the first evidence that interactive confrontation with racism elicits significant increases in CV reactivity and emotional distress. Furthermore, individuals receiving less support may be at greater risk for the potentially health-damaging effects of racial stress. These findings may have significant implications for the health of African Americans. 相似文献
135.
N. K. Kaushik Parul Sharma Ashok Shah T. A. Venkitasubramanian 《Medical microbiology and immunology》1993,182(6):317-327
The phospholipid-associated protein (55–67 kDa) fraction of Mycobacterium tuberculosis H37Rv was purified as the DE-V protein fraction. This DE-V fraction was used for diagnosis of tuberculosis by enzyme-linked immunosorbent assay (ELISA), detecting IgG antibody in sera collected from different categories of tuberculosis patients, i.e. with acid fast bacilli (AFB) culture-positive pulmonary tuberculosis, with AFB culture-negative, but radiologically suspected, pulmonary tuberculosis, extrapulmonary tuberculosis, and control groups of patients suffering from diseases other than tuberculosis (asthma and/or rhinitis, lepromatous leprosy) as well as from healthy volunteers. Encouraging operational ELISA validity could be achieved with 93% sensitivity, 100% specificity, 97% efficiency, 100% positive predictivity and 95% negative predictability even among the extrapulmonary and suspected pulmonary tuberculosis patients. The above assay was insensitive but with 100% specificity among control group of patients suffering from diseases other than tuberculosis. The DE-V protein fraction was associated with phosphatidyl inositol and phosphatidyl inositol mannosides. The dissociation of phospholipid-protein complex decreased ELISA specificity. ELISA reactivity of the DE-V fraction appeared to be thermostable; thus, it may have serodiagnostic utility in developing countries. 相似文献
136.
Siddharth K. Prakash Soniely Lugo‐Ruiz Michelle Rivera‐Dávila Nunilo Rubio Jr. Avni N. Shah Rebecca C. Knickmeyer Cindy Scurlock Melissa Crenshaw Shanlee M. Davis Gary A. Lorigan Aaron T. Dorfman Karen Rubin Cheryl Maslen Vaneeta Bamba Paul Kruszka Michael Silberbach Scientific Advisory Board of the TSRR 《American journal of medical genetics. Part C, Seminars in medical genetics》2019,181(1):7-12
To address knowledge gaps about Turner syndrome (TS) associated disease mechanisms, the Turner Syndrome Society of the United States created the Turner Syndrome Research Registry (TSRR), a patient‐powered registry for girls and women with TS. More than 600 participants, parents or guardians completed a 33‐item foundational survey that included questions about demographics, medical conditions, psychological conditions, sexuality, hormonal therapy, patient and provider knowledge about TS, and patient satisfaction. The TSRR platform is engineered to allow individuals living with rare conditions and investigators to work side‐by‐side. The purpose of this article is to introduce the concept, architecture, and currently available content of the TSRR, in anticipation of inviting proposals to utilize registry resources. 相似文献
137.
138.
139.
140.
Bhatt AD Dalal DG Shah SJ Joshi BA Gajjar MN Vaidya RA Vaidya AB Antarkar DS 《Journal of postgraduate medicine》1995,41(1):5-7
An open comparative trial was conducted in 58 adult obese patients (Body Mass Index > or = 25 kg/square metre). Group I (n = 27), non-drug, was advised diet (1200-1600 cals) and a brisk walk for 30 minutes. Group II, in addition, received Guggulu (Medohar) 1.5-3 gms/day for 30 days. Mean difference in weight loss between Guggulu and non-drug group was 0.32 kg (ns) on day 15 and 0.58 kg on day 30 (ns). The mean weight reduction in patients (> 90 kgs) was 1.92 kg (ns) and 2.25 kg (ns) higher in Guggulu group. All patients weighing > 90 kg lost weight in Guggulu group whilst 3 in non-drug group did not lose weight. Guggulu was tolerated well. The data from this pilot study suggest a synergistic diet-Guggulu interaction over 30 days in patients weighing > 90 kgs which needs to be confirmed in a large placebo controlled study. 相似文献