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Incremental value of live/real time three‐dimensional transesophageal echocardiography in the assessment of ventricular septal rupture following acute myocardial infarction 下载免费PDF全文
Mohammed J. Arisha MD Ming C. Hsiung MD Navin C. Nanda MD Bulur Serkan MD Amier Ahmad MD Ahmed Elkaryoni MD Mahmoud Elsayed MD Leilani Adana MD Shravan Turaga MD Emel Guler MD Nermina Alagic MD 《Echocardiography (Mount Kisco, N.Y.)》2017,34(11):1680-1686
Ventricular septal rupture is a serious complication following acute myocardial infarctions and is associated with a significant mortality rate. Classically, two‐dimensional transthoracic echocardiography has been used to diagnose this complication and visualize its location. Two‐dimensional transesophageal echocardiography has supplemented the transthoracic approach by providing more accurate assessment of the defect size and in guiding closure both percutaneously and intraoperatively. This modality, however, is limited to two‐dimensional views only, and a greater breadth of information is instead available through the use of three‐dimensional transesophageal echocardiography. We present a series of 11 patients in which live/real time three‐dimensional transesophageal echocardiography offered incremental benefits over two‐dimensional imaging alone. 相似文献
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Barbara Domańska Oliver Stumpp Steven Poon Serkan Oray Irina Mountian Clovis Pichon 《Advances in therapy》2018,35(1):100-115
Introduction
We incorporated patient feedback from human factors studies (HFS) in the patient-centric design and validation of ava®, an electromechanical device (e-Device) for self-injecting the anti-tumor necrosis factor certolizumab pegol (CZP).Methods
Healthcare professionals, caregivers, healthy volunteers, and patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, or Crohn’s disease participated in 11 formative HFS to optimize the e-Device design through intended user feedback; nine studies involved simulated injections. Formative participant questionnaire feedback was collected following e-Device prototype handling. Validation HFS (one EU study and one US study) assessed the safe and effective setup and use of the e-Device using 22 predefined critical tasks. Task outcomes were categorized as “failures” if participants did not succeed within three attempts.Results
Two hundred eighty-three participants entered formative (163) and validation (120) HFS; 260 participants performed one or more simulated e-Device self-injections. Design changes following formative HFS included alterations to buttons and the graphical user interface screen. All validation HFS participants completed critical tasks necessary for CZP dose delivery, with minimal critical task failures (12 of 572 critical tasks, 2.1%, in the EU study, and 2 of 5310 critical tasks, less than 0.1%, in the US study).Conclusion
CZP e-Device development was guided by intended user feedback through HFS, ensuring the final design addressed patients’ needs. In both validation studies, participants successfully performed all critical tasks, demonstrating safe and effective e-Device self-injections.Funding
UCB Pharma.Plain Language Summary
Plain language summary available on the journal website.20.
Türkuçar Serkan Yıldız Kaan Küme Tuncay Açarı Ceyhun Dundar Hatice Adıgüzel Makay Balahan Kır Mustafa Ünsal Erbil 《Clinical rheumatology》2021,40(10):4199-4206
Clinical Rheumatology - This study aimed to evaluate the risk for atherosclerosis by using echocardiographic arterial stiffness (AS) parameters and serum endocan levels, as a biomarker of... 相似文献