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排序方式: 共有1646条查询结果,搜索用时 15 毫秒
71.
Lydie Boussicault Anne-Sophie Hérard Noel Calingasan Fanny Petit Carole Malgorn Nicolas Merienne Caroline Jan Marie-Claude Gaillard Rodrigo Lerchundi Luis F Barros Carole Escartin Thierry Delzescaux Jean Mariani Philippe Hantraye M Flint Beal Emmanuel Brouillet Céline Véga Gilles Bonvento 《Journal of cerebral blood flow and metabolism》2014,34(9):1500-1510
Huntington''s disease (HD) is caused by cytosine-adenine-guanine (CAG) repeat expansions in the huntingtin (Htt) gene. Although early energy metabolic alterations in HD are likely to contribute to later neurodegenerative processes, the cellular and molecular mechanisms responsible for these metabolic alterations are not well characterized. Using the BACHD mice that express the full-length mutant huntingtin (mHtt) protein with 97 glutamine repeats, we first demonstrated localized in vivo changes in brain glucose use reminiscent of what is observed in premanifest HD carriers. Using biochemical, molecular, and functional analyses on different primary cell culture models from BACHD mice, we observed that mHtt does not directly affect metabolic activity in a cell autonomous manner. However, coculture of neurons with astrocytes from wild-type or BACHD mice identified mutant astrocytes as a source of adverse non-cell autonomous effects on neuron energy metabolism possibly by increasing oxidative stress. These results suggest that astrocyte-to-neuron signaling is involved in early energy metabolic alterations in HD. 相似文献
72.
Patricia Facchinetti Emilie Dorard Vincent Contremoulins Marie-Claude Gaillard Nicole Déglon Véronique Sazdovitch Chantal Guihenneuc-Jouyaux Emmanuel Brouillet Charles Duyckaerts Bernadette Allinquant 《Neurobiology of aging》2014
Caspase cleaved amyloid precursor protein (APPcc) and SET are increased and mislocalized in the neuronal cytoplasm in Alzheimer Disease (AD) brains. Translocated SET to the cytoplasm can induce tau hyperphosphorylation. To elucidate the putative relationships between mislocalized APPcc and SET, we studied their level and distribution in the hippocampus of 5 controls, 3 Down syndrome and 10 Alzheimer patients. In Down syndrome and Alzheimer patients, APPcc and SET levels were increased in CA1 and the frequency of both localizations in the neuronal cytoplasm was high in CA1, and low in CA4. As the increase of APPcc is already present at early stages of AD, we overexpressed APPcc in CA1 and the dentate gyrus neurons of adult mice with a lentiviral construct. APPcc overexpression in CA1 and not in the dentate gyrus induced endogenous SET translocation and tau hyperphosphorylation. These data suggest that increase in APPcc in CA1 neurons could be an early event leading to the translocation of SET and the progression of AD through tau hyperphosphorylation. 相似文献
73.
Lo?c Le Dé JC Gaillard Anthony Gampell Nickola Loodin Graham Hinchliffe 《国际灾害风险科学学报(英文版)》2021,(6):867-878
This article focuses on children's participation in disaster risk reduction.It draws on a 2018 study done in New Zealand with 33 school children who conducted p... 相似文献
74.
Morokoff Andrew Jones Jordan Nguyen Hong Ma Chenkai Lasocki Arian Gaillard Frank Bennett Iwan Luwor Rod Stylli Stanley Paradiso Lucia Koldej Rachel Paldor Iddo Molania Ramyar Speed Terence P. Webb Andrew Infusini Guiseppe Li Jason Malpas Charles Kalincik Tomas Drummond Katharine Siegal Tali Kaye Andrew H. 《Journal of neuro-oncology》2020,148(3):401-418
Journal of Neuro-Oncology - We performed a systematic review and meta-analysis of clinical outcomes for patients with acromegaly treated with stereotactic radiosurgery (SRS). Primary outcomes were... 相似文献
75.
Aleida Rivas Mark Landon Trudy Gaillard Dara Schuster Kwame Osei 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2010,4(2):89-94
AimsTo assess the awareness of risk factors for type 2 diabetes and lifestyle changes that can decrease such risks in women with GDM.MethodsThe study comprised responses to health questionnaires by 319 women: 31 pregnant women with current GDM (CGDM), 88 women with previous GDM (PGDM), 100 pregnant women without DM (PWDM) and 100 non-pregnant women without DM (NPWDM). The CGDM group answered the questionnaires at the initiation and 4 weeks after participating in formal education on GDM. Two types of awareness scores (AS) were established. One AS was about the risks associated with GDM (GDMR), and the other was related to the awareness of lifestyle changes that can decrease the risks of type 2 diabetes (DM2R).ResultsThe PGDM group had the highest GDMR and DM2R scores (9.55 ± 2.66) (13.2 ± 2.26) compared with the other groups (CGDM 7.48 ± 3.14, NPWDM 6.10 ± 3.17, PWDM 2.89 ± 2.48) (p < 0.05) and (NPWDM 12.05 ± 2.73, CGDM 11.29 ± 2.45, PWDM 8.27 ± 4.14) (p < 0.05). The CGDM group increased the GDMR score from 7.48 ± 3.14 to 10.54 ± 2.57 (p < 0.0001) and the DM2R score from 11.29 ± 2.45 to 14.04 ± 1.26 (p < 0.001).ConclusionsWomen had limited awareness of risk factors for type 2 diabetes and lifestyle modifications that can decrease such risk of diabetes. AS were higher in women with current and previous GDM after receiving formal education. 相似文献
76.
77.
Functional MRI (fMRI), a tool increasingly used to study cognitive function, is also an important tool for understanding not
only normal development in healthy children, but also abnormal development, as seen in children with epilepsy, attention-deficit/hyperactivity
disorder, and autism. Since its inception almost 15 years ago, fMRI has seen an explosion in its use and applications in the
adult literature. However, only recently has it found a home in pediatric neurology. New adaptations in study design and technologic
advances, especially the study of resting state functional connectivity as well as the use of passive task design in sedated
children, have increased the utility of functional imaging in pediatrics to help us gain understanding into the developing
brain at work. This article reviews the background of fMRI in pediatrics and highlights the most recent literature and clinical
applications. 相似文献
78.
79.
Congenital diaphragmatic hernia: new models,new ideas 总被引:1,自引:0,他引:1
A. E. Brandsma R. Tenbrinck H. Ijsselstijn E. C. Scheffers J. L. J. Gaillard D. Kluth A. A. W. ten Have-Opbroek B. Lachmann D. Tibboel 《Pediatric surgery international》1995,10(1):10-15
An animal model for congenital diaphragmatic hernia following interference with the development of the primary lung bud by 2,4-dinitro-p-diphenylether (nitrofen) is described. It has been used for pathogenetic studies to evaluate the presence of pulmonary hypoplasia and a closing defect of the diaphragm. Functional studies revealed abnormal surfactant levels and differences in pressure/volume curves following birth and during artificial ventilation for 6 h together with a disturbed antioxidant enzyme response. This animal model opens up new ways of studying the effects of prenatal hormonal modulation (corticosteroids, thyrotrophin-releasing hormone) on lung development as a novel therapeutic modality. 相似文献
80.
Y Lenne A Gaillard J Bonnard J Billet M Fiche A Gordeeff G Ayoun 《Revue de stomatologie et de chirurgie maxillo-faciale》1985,86(6):378-381
A rare affection of unknown etiology that is benign but frequently recurrent, Kimura's disease involves infiltration of the dermis and hypodermis usually of the face. Documented data exists describing clinical findings and results of histopathology that are analogous but are grouped under other names: angiolymphoid hyperplasia with eosinophilia, pyogenic pseudogranuloma, atypical pyogenic granuloma. A case followed up for 13 years is reported. 相似文献