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81.
Aysun Ankay Yilbas Cigdem Kanburoglu Filiz Uzumcugil Coskun Cifci Ozge Ozen Saralp Heves Karagoz Seda Banu Akinci Anil Arat 《Brazilian Journal of Anesthesiology》2018,68(2):194-196
Background
Cervical hematomas can lead to airway compromise, a life threatening condition, regardless of the cause. The following case is the first presentation of cervical hematoma as a complication of endovascular treatment of middle cerebral artery aneurysm.Case report
A 49 year‐old woman was scheduled for stent placement under general anesthesia for middle cerebral artery aneurysm. Few days before intervention, acetyl salicylic acid and clopidogrel treatment was started. Following standard monitoring and anesthesia induction, the patient's trachea was intubated with a 7.5 mm endotracheal tube and the procedure was completed without any complications. Three hours later, dyspnea developed and physical examination revealed progressive swelling and stiffness in the neck. Endotracheal intubation was performed with a 6 mm diameter uncuffed tube with the aid of sedation. The vocal cords were completely closed due to compression. There was no leak around the endotracheal tube. The rapidly performed computerized tomography scans showed an enormous hematoma around the neck and extravasation of contrast medium through superior thyroid artery. After coil embolization of superior thyroid artery, she was taken to the intensive care unit as intubated and sedated. Surgical exploration of the hematoma was not recommended by the surgeons, because she was on clopidogrel. After two days, the patient's trachea was extubated safely ensuring that the swelling was sufficiently ceased and leak detected around the endotracheal tube.Conclusions
Securing the airway rapidly by endotracheal intubation is the most crucial point in the management of cervical hematomas. Diagnostic and therapeutic procedures should be performed only afterwards. 相似文献82.
Anıl Sera Çakmak Soner Çakmak H. Seda Vatansever Menemşe Gümüşderelioğlu 《Lasers in medical science》2018,33(4):785-794
Low-level laser therapy (LLLT) has been used for more than 30 years to heal wounds. In recent years, LLLT or photostimulation has been indicated as an effective tool for regenerative and dental medicine by using monochromatic light. The aim of this study is to indicate the usability of plasma arc light source for bone regeneration. This is why we used polychromatic light source providing effective wavelengths in the range of 590–1500 nm for cellular response and investigated photostimulation effects on osteogenic differentiation of human mesenchymal stem cells (hMSCs) seeded on 3D silk scaffolds. Cellular responses were examined by using cell culture methods in terms of proliferation, differentiation, and morphological analyses. The results showed that photostimulation with a polychromatic light source (applied for 5 min from the 3rd day after seeding up to the 28th day in 2-day intervals with 92-mW/cm2 power from 10-cm distance to the cells) enhanced osteogenic differentiation of hMSCs according to higher alkaline phosphatase (ALP) activity, collagen and calcium content, osteogenic gene expressions, and matrix mineralization. In conclusion, we suggest that the plasma arc light source that was used here has a great potential for bone regeneration. 相似文献
83.
Mesenchymal stem cells and ligand incorporation in biomimetic poly(ethylene glycol) hydrogels significantly improve insulin secretion from pancreatic islets 下载免费PDF全文
Tuğba Bal Caner Nazli Alparslan Okcu Gökhan Duruksu Erdal Karaöz Seda Kizilel 《Journal of tissue engineering and regenerative medicine》2017,11(3):694-703
The main goal of this study was to investigate pancreatic islet function with mesenchymal stem cells (MSCs) in a ligand‐functionalized poly(ethylene glycol) (PEG) hydrogel for the treatment of type 1 diabetes (T1D). Rat bone marrow‐derived MSCs (rBM‐MSCs) were encapsulated within synthetic PEG hydrogel, and cell viability and apoptosis within this 3D environment was examined in detail. ATP content and caspase‐3 activity of encapsulated MSCs showed that fibronectin‐derived RGDS, laminin‐derived IKVAV and/or insulinotropic glucagon‐like peptide (GLP‐1) were required to maintain MSC survival. Incorporation of these peptides into the hydrogel environment also improved pancreatic islet viability, where combinations of peptides had altered effects on islet survival. GLP‐1 alone was the leading stimulator for insulin secretion. Cell adhesion peptides RGDS and IKVAV improved insulin secretion only when they were used in combination, but could not surpass the effect of GLP‐1. Further, when pancreatic islets were co‐encapsulated with MSCs within synthetic PEG hydrogel, a two‐fold increase in the stimulation index was measured. Synergistic effects of MSCs and peptides were observed, with a seven‐fold increase in the stimulation index. The results are promising and suggest that simultaneous incorporation of MSCs and ECM‐derived peptides and/or GLP‐1 can improve pancreatic islet function in response to altered glucose levels in the physiological environment. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
84.
85.
Erdal Karakaya Oğuz Ateş Feza M. Akgür Mustafa Olguner 《International urology and nephrology》2010,42(2):357-360
Recently, anti-inflammatory and tissue protective effects of statins have been shown independent from its anti-hyperlipidemic
effect. It has been shown that one of the statins, rosuvastatin, may reduce ischemia/reperfusion (I/R)-induced tissue injury
in the brain, intestines, and heart. We planned an experimental study to evaluate the effect of rosuvastatin on I/R injury
encountered after the detorsion of the testicular torsion. Rats were divided into three groups. In group 1, testis basal blood
flow (basal value) was measured with LASER Doppler flowmeter (LDF). Testis was relocated into the scrotum without torsion.
Two and 3 h after the basal measurement, testis was brought out from the same incision, and the second (second value) and
third (third value) testicular blood flow measurements were done, respectively. In group 2, after the measurement of basal
value testicular torsion was created. Second and third value measurements were obtained with LDF at the end of the 2 h of
testicular torsion just before the detorsion and 1 h after detorsion. In group 3, same procedures in torsion/detorsion group
were repeated in this group, but 10 mg/kg rosuvastatin was injected intraperitoneally 30 min before detorsion. Second values
in groups 2 and 3 were significantly lower than group 1. Third values were significantly low in group 2 compared to groups
1 and 3. Regarding the third measurement, there was no significant difference between the groups 1 and 3. Tissue injury is
closely related with condition of microvascular perfusion after I/R. Rosuvastatin can protect tissue perfusion in the experimental
testicular torsion model. 相似文献
86.
Diabetic foot disease causes important morbidity in diabetic population, and amputation due to diabetic foot disease occurs more often than in general population. We have been evaluating patients with diabetic foot disease in a multidisciplinary approach since year 2000. In the current study, we sought to investigate the change in amputation rate and its predictors in diabetic foot with a multidisciplinary team approach. Seventy-four patients (52 male, 22 female) hospitalised between January 2002 and December 2007 were retrospectively analysed. Sixteen out of 74 have undergone amputation. We found overall amputation rate as 21.6%, which is lower than previously reported from our institution (36.7 and 39.4%, respectively). Major amputations (syme, below-knee, above-knee) were applied to 11 patients (14.9%). A logistic regression model including osteomyelitis, peripheral neuropathy, peripheral vascular disease, hypertension, gangrene and age revealed that gangrene is now the only significant predictor for amputation. Our observations confirm that amputation rate has declined after implementation of a multidisciplinary team work, and risk factors apart from presence of gangrene are no longer amputation predictors in our centre. 相似文献
87.
88.
Gopalan RC Emerce E Wright CW Karahalil B Karakaya AE Anderson D 《Toxicology letters》2011,207(3):322-325
Malaria is a mosquito-borne infectious disease caused by the genus Plasmodium. It causes one million deaths per year in African children under the age of 5 years. There is an increasing development of resistance of malarial parasites to chloroquine and other currently used anti-malarial drugs. Some plant products such as the indoloquinoline alkaloid cryptolepine have been shown to have potent activity against P. falciparum in vitro. On account of its toxicity, cryptolepine is not suitable for use as an antimalarial drug but a number of analogues of cryptolepine have been synthesised in an attempt to find compounds that have reduced cytotoxicity and these have been investigated in the present study in human sperm and lymphocytes using the Comet assay. The results suggest that cryptolepine and the analogues cause DNA damage in lymphocytes, but appear to have no effect on human sperm at the assessed doses. In the context of antimalarial drug development, the data suggest that all cryptolepine compounds and in particular 2,7-dibromocryptolepine cause DNA damage and therefore may not be suitable for pre clinical development as antimalarial agents. 相似文献
89.
Ozdemir E Cetinkaya S Ersan S Kucukosman S Ersan EE 《Progress in neuro-psychopharmacology & biological psychiatry》2009,33(1):62-65
There is mounting evidence indicating that reactive free radical species are involved in initiation and development of many different forms of human pathologies including psychiatric disorders. In the present study, we aimed to determine whether serum selenium (Se), antioxidant enzyme (glutathione peroxidase, GSH-Px, superoxide dismutase, SOD, and catalase, CAT) activities, and plasma malondialdehyde (MDA) levels, a product of lipid peroxidation, were associated with obsessive-compulsive disorder (OCD). The participants were 28 patients with OCD that were drug-free at least for a month and a control group (n=28) of healthy subjects, matched with respect to age and sex. In both groups, the levels of the erythrocyte MDA, GSH-Px, SOD, Se, and the CAT were measured. The levels of MDA and SOD were statistically significantly higher (p<0.01, p<0.05 respectively) in patients than controls. The activities of CAT, GSH-Px, and serum Se levels were statistically significantly lower (p<0.0001, p<0.001, and p<0.001 respectively) in patients than controls. There was a positive correlation in patients between plasma GSH-Px activity and Se concentration (r=52, p=0.001). However, in patients with OCD, CAT and SOD activities were significantly and negatively correlated with MDA levels (r=-0.45, p=0.017 for CAT and r=-0.54, p=0.020 for SOD). The study shows the presence of a significant relationship of OCD and oxidative stress, and consequently, an involvement of free radicals and of the antioxidant defence. 相似文献
90.