全文获取类型
收费全文 | 188235篇 |
免费 | 13988篇 |
国内免费 | 775篇 |
专业分类
耳鼻咽喉 | 2135篇 |
儿科学 | 4852篇 |
妇产科学 | 3450篇 |
基础医学 | 24366篇 |
口腔科学 | 3801篇 |
临床医学 | 19176篇 |
内科学 | 37977篇 |
皮肤病学 | 2520篇 |
神经病学 | 16435篇 |
特种医学 | 7423篇 |
外科学 | 30553篇 |
综合类 | 2661篇 |
现状与发展 | 1篇 |
一般理论 | 228篇 |
预防医学 | 17673篇 |
眼科学 | 4135篇 |
药学 | 13394篇 |
3篇 | |
中国医学 | 227篇 |
肿瘤学 | 11988篇 |
出版年
2023年 | 959篇 |
2022年 | 1466篇 |
2021年 | 3640篇 |
2020年 | 2069篇 |
2019年 | 3411篇 |
2018年 | 4149篇 |
2017年 | 2997篇 |
2016年 | 3184篇 |
2015年 | 3851篇 |
2014年 | 5697篇 |
2013年 | 8375篇 |
2012年 | 12343篇 |
2011年 | 13034篇 |
2010年 | 7196篇 |
2009年 | 6557篇 |
2008年 | 11487篇 |
2007年 | 12349篇 |
2006年 | 11849篇 |
2005年 | 11875篇 |
2004年 | 11301篇 |
2003年 | 10660篇 |
2002年 | 10329篇 |
2001年 | 2128篇 |
2000年 | 1878篇 |
1999年 | 2204篇 |
1998年 | 2228篇 |
1997年 | 1781篇 |
1996年 | 1712篇 |
1995年 | 1702篇 |
1994年 | 1447篇 |
1993年 | 1385篇 |
1992年 | 1372篇 |
1991年 | 1341篇 |
1990年 | 1249篇 |
1989年 | 1189篇 |
1988年 | 1178篇 |
1987年 | 1106篇 |
1986年 | 1136篇 |
1985年 | 1256篇 |
1984年 | 1267篇 |
1983年 | 1160篇 |
1982年 | 1374篇 |
1981年 | 1380篇 |
1980年 | 1169篇 |
1979年 | 867篇 |
1978年 | 895篇 |
1977年 | 778篇 |
1976年 | 700篇 |
1975年 | 642篇 |
1974年 | 680篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
22.
Richard Kim Elaine Tan Emily Wang Amit Mahipal Dung-Tsa Chen Biwei Cao Fadzai Masawi Cindy Machado James Yu Dae Won Kim 《The oncologist》2020,25(12):e1893-e1899
Lessons Learned
- The combination of trametinib and sorafenib has an acceptable safety profile, albeit at doses lower than approved for monotherapy.
- Maximum tolerated dose is trametinib 1.5 mg daily and sorafenib 200 mg twice daily.
- The limited anticancer activity observed in this unselected patient population does not support further exploration of trametinib plus sorafenib in patients with hepatocellular carcinoma.
23.
24.
Paul J. Devlin Brian W. McCrindle James K. Kirklin Eugene H. Blackstone William M. DeCampli Christopher A. Caldarone Ali Dodge-Khatami Pirooz Eghtesady James M. Meza Peter J. Gruber Kristine J. Guleserian Bahaaladin Alsoufi Linda M. Lambert James E. OBrien Erle H. Austin Jeffrey P. Jacobs Tara Karamlou 《The Journal of thoracic and cardiovascular surgery》2019,157(2):684-695.e8
Objective
Arch obstruction after the Norwood procedure is common and contributes to mortality. We determined the prevalence, associated factors, and practice variability of arch reintervention and assessed whether arch reintervention is associated with mortality.Methods
From 2005 to 2017, 593 neonates in the Congenital Heart Surgeons' Society Critical Left Heart Obstruction cohort underwent a Norwood procedure. Median follow-up was 3.7 years. Multivariable parametric models, including a modulated renewal analysis, were performed.Results
Of the 593 neonates, 146 (25%) underwent 218 reinterventions for arch obstruction after the Norwood procedure: catheter-based (n = 168) or surgical (n = 50) at a median age of 4.3 months (quartile 1-quartile 3, 2.6-5.7). Interdigitation of the distal aortic anastomosis was protective against arch reintervention. Development of ≥ moderate tricuspid valve regurgitation and right ventricular dysfunction at any point was associated with arch reintervention. Nonsignificant variables for arch reintervention included shunt type and preoperative aortic measurements. Surgical arch reintervention was protective against arch reintervention, but transcatheter reintervention was associated with increased reintervention. Arch reintervention was not associated with increased mortality. There was wide institutional variation in incidence of arch reintervention (range, 0-40 reinterventions per 100 years patient follow-up) and in preintervention gradient (range, 0-64 mm Hg).Conclusions
Interdigitation of the distal aortic anastomosis during the Norwood procedure decreased the risk of arch reintervention. Surgical arch reintervention is more definitive than transcatheter. Arch reintervention after the Norwood procedure is not associated with increased mortality. Serial surveillance for arch obstruction, integrated with changes in right ventricular function and tricuspid valve regurgitation, is recommended after the Norwood procedure to improve outcomes. 相似文献25.
26.
27.
28.
Turnbull Chris D. Stockley James A. Madathil Shyam Huq Syed S. A. Cooper Brendan G. Ali Asad Wharton Simon Stradling John R. Heitmar Rebekka 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2022,260(7):2129-2139
Graefe's Archive for Clinical and Experimental Ophthalmology - Retinal microvascular endothelial dysfunction is thought to be of importance in the development of ocular vascular diseases.... 相似文献
29.
Edmund Sonuga-Barke Pasco Fearon Stephen Scott 《Journal of child psychology and psychiatry, and allied disciplines》2022,63(1):1-3
The recent death of our colleague and friend Professor Sir Michael Rutter has quite rightly been greeted by an outpouring of gratitude and respect from distinguished commentators across the globe working in diverse fields of the basic, social and clinical sciences as well as from clinicians and policy makers. These have without exception highlighted his seminal role as a pioneer, perhaps The Pioneer, of the application of the scientific method to the study of child and adolescent mental health and disorder – the father of evidence-based Child Psychiatry and the most influential voice in the new field of Developmental Psychopathology (Stevenson, 2022). In this editorial, we will attempt to build on these commentaries. We will parse Mike’s scientific contributions to our field, in order to identify the personal characteristics and intellectual modus operandi that made him such a uniquely important figure, whose influence will resonate through the many fields he influenced for decades to come. We will also attempt something of a reframing of that contribution. Our thesis being that, although he never agitated for it politically or even stated it as a goal explicitly, Mike’s work was motivated by a desire for social reform and created the scientific catalyst for such reform to occur. 相似文献
30.
Alexander Real Chierika Ukogu Divya Krishnamoorthy Nicole Zubizarreta Samuel K. Cho Andrew C. Hecht James C. Iatridis 《The spine journal》2019,19(2):225-231