Aortopulmonary collateral artery embolization during postoperative extracorporeal membrane oxygenation after arterial switch procedure

Aortopulmonary collateral arteries sometimes complicate cyanotic congenital heart defects. Combined with a relevant left-right shunt, this could result in massive airway bleeding during and after corrective surgery. A preoperatively diagnosed 1.2 mm small aortopulmonary collateral artery in a newborn suffering from transposition of the great arteries caused life-threatening airway bleeding during surgery. Postoperative extracorporeal membrane oxygenation (ECMO) was necessary, and coil embolization was performed on ECMO to terminate pulmonary bleeding.     

Clonidine induced hyperphagia and weight gain in monkeys

The effect of the -noradrenergic receptor agonist, clonidine, on food intake and weight was examined in ten adult Stumptail macaque monkeys. An intramuscular injection of 0.1 mg/kg of clonidine HCl for seven consecutive days significantly increased food intake from baseline levels throughout treatment. All but two monkeys gained weight during clonidine treatment with seven animals gaining from 5–15% of their original body weight by the end of 1 week.To whom offprint requests should be sent     

心脏不停跳心内直视手术对心肌保护效应的研究

目的　观察心脏跳动下心内直视手术对心肌的保护效应。方法　选择常温下心脏不停跳心内直视手术患者 2 0例为实验组 ,浅低温心脏停跳下手术患者 2 0例为对照组。观察2组患者磷酸肌酸激酶 (CK -MB)、心肌细胞凋亡及心肌细胞超微结构的变化。结果　术后 12h及 2 4h ,实验组CK -MB低于对照组 ,术后 4 8h 2组均恢复正常 ;实验组心肌细胞凋亡率和心肌细胞超微结构破坏程度均明显低于对照组。结论　常温下心脏不停跳心内直视手术仍存在一定程度的心肌损伤 ,但较浅低温心脏停跳术减轻 ,对心肌有一定保护作用     

环氧合酶-2、P-gp在胃癌组织中的表达及其意义

目的　探讨环氧合酶 2 (COX 2 )在胃癌组织中的表达及其对P糖蛋白 (P gp)表达的影响。 方法　应用免疫组织化学方法 ,检测 48例胃癌及 10例正常胃组织中COX 2与P gp的表达。 结果　正常胃组织中未见COX 2表达 ,胃癌组织中COX 2表达阳性率为 60 .4% ( 2 9/ 48) ,其阳性表达与肿瘤的TNM分期及淋巴结转移相关 (P <0 .0 5 )。COX 2阳性组中P gp表达阳性率为 82 .8% ( 2 4/ 2 9) ,而COX 2阴性组P gp同时阴性表达率为 63 .2 % ( 12 / 19) ,两者表达呈高度正相关 (γ =0 .470 ,P <0 .0 1)。 结论COX 2表达参与胃癌的发生及恶性进展 ,并可能通过干预P gp的表达参与对肿瘤多药耐药 (MDR)的调节作用     

中药干预应激性溃疡大鼠模型的实验研究

【目的】初步探讨应激性溃疡的中医学病理机制。【方法】采用水浸束缚造成大鼠应激性胃溃疡模型。将60只大鼠随机分为5组，即正常空白组、造模组、心身1号组、雷尼替丁组、阿普唑仑组。观察不同药物对大鼠应激性溃疡发生的干预作用。【结果】不同给药组大鼠胃黏膜溃疡指数、pH值均存在显著差异。中药组大鼠的溃疡指数低于造模组，但中药组pH值与造模组无差异。【结论】行气活血、降逆散结的中药心身1号片可以预防应激性溃疡的发生。应激性溃疡的基本病机为气机紊乱。     

四格表指标统计分析报表的SAS宏程序

为规范临床试验数据管理,简化程序并减少数据统计分析过程中的错误来源,我们编制了一些特定的SAS宏程序,可以直接输出临床试验四格表指标统计分析报表。     

新生儿及婴儿完全型肺静脉异位引流的外科治疗

目的　回顾性探讨新生儿及婴儿完全型肺静脉异位引流 (TAPVC)的早期外科手术效果。方法　 2 0 0 1年 3月～ 2 0 0 3年 4月 ,共收治 8kg以下完全型肺静脉异位引流患儿 13例 ,男 11例 ,女 2例。体重 (3.5～ 8)kg ,平均体重 (5 .0 3± 1.15 )kg。年龄 2 0d～ 11个月 ,平均年龄 (3.73± 3.30 )个月。心上型 6例 (4 6 .15 % 6 /13) ,心内型 4例 (30 .77% 4 /13) ,心下型 2例 (15 .38% 2 /13) ,混合型 1例 (7.6 9% 1/13)。所有患儿均在全麻低温体外循环下行矫治术。结果　术后早期死亡 2例(15 .38% ) ,均为心上型 ,2例心下型全部存活 ,随访 9例 ,时间为 2个月～ 2年 ,心功能均良好。结论　完全型肺静脉异位引流早期矫治效果良好 ,心下型肺静脉异位引流一旦确诊应急诊手术 ,不增加手术死亡率。     

2005年吉林省农村生活饮用水监测县水质分级评价

目的掌握吉林省农村生活饮用水基本状况，并为农村改水工作提供科学的依据。方法依据“农村实施《生活饮用水卫生标准》准则”，对2005年吉林省农村生活饮用水监测县的枯水期和丰水期水质分别进行分级评价。结果100个监测水点中，枯水期安全饮用水监测点数34个，非安全饮用水监测点数66个；丰水期安全饮水的监测点数66个，非安全饮用水监测点是34个。结论细菌总数和大肠菌群这两项微生物学指标是影响本省农村饮水水质的重要因素。必须进行适当净化和消毒处理，加强对饮水水源的卫生防护，以保障农村居民的身体健康。     

西酞普兰和阿米替林治疗老年抑郁症效果比较

目的比较西酞普兰与阿米替林治疗老年抑郁症的疗效及不良反应。方法将72例符合CCMD-3诊断标准的老年抑郁症病人随机分为两组,分别采用西酞普兰和阿米替林治疗8周,采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)和副反应量表(TESS)评定疗效和不良反应。结果西酞普兰组疗效优于阿米替林组(uc=1.81,P<0.05),副作用轻于阿米替林组(t=5.01~15.91,P<0.05、0.01)。结论西酞普兰是一种既有效又安全的新型抗抑郁药,适用于老年抑郁症的治疗。     

Paramagnetic thermosensitive liposomes for MR-thermometry.

MR-thermometry methods have been developed for the guidance and control of thermal therapies such as thermal ablation or regional hyperthermia. However, they are limited to the measurement of temperature changes and, thus, cannot be used to assess absolute temperature values. Paramagnetic thermosensitive liposomes are innovative contrast agents offering the potential to overcome these limitations. They are composed of a gadolinium- or manganese-based compound enclosed by a phospholipid membrane with a distinct gel-to-liquid crystalline phase transition temperature (Tm). At this temperature, the phospholipid membrane changes from a gel-phase to a liquid-crystalline phase which is associated with an increased transmembrane permeability towards solutes and water. Under these conditions, both types of paramagnetic thermosensitive liposomes demonstrate a significant increase in longitudinal (T1) relaxivity, attributed to the release of paramagnetic material from the liposome and/or to the increased water exchange rate between the liposome interior and exterior. Paramagnetic thermosensitive liposomes have already been successfully studied in animal models and have demonstrated a clear correlation between tissue temperature changes and signal intensity changes in MRI. Nevertheless, before entering clinical trials they have to be studied in more detail with regard to dose, pharmacokinetics and toxicity.