全文获取类型
收费全文 | 76662篇 |
免费 | 3821篇 |
国内免费 | 214篇 |
专业分类
耳鼻咽喉 | 1150篇 |
儿科学 | 2310篇 |
妇产科学 | 1736篇 |
基础医学 | 11574篇 |
口腔科学 | 2496篇 |
临床医学 | 6899篇 |
内科学 | 13930篇 |
皮肤病学 | 2115篇 |
神经病学 | 7822篇 |
特种医学 | 3867篇 |
外国民族医学 | 23篇 |
外科学 | 10637篇 |
综合类 | 286篇 |
一般理论 | 39篇 |
预防医学 | 4812篇 |
眼科学 | 1576篇 |
药学 | 5393篇 |
1篇 | |
中国医学 | 113篇 |
肿瘤学 | 3918篇 |
出版年
2023年 | 405篇 |
2022年 | 288篇 |
2021年 | 630篇 |
2020年 | 677篇 |
2019年 | 746篇 |
2018年 | 1536篇 |
2017年 | 1299篇 |
2016年 | 1697篇 |
2015年 | 1509篇 |
2014年 | 1667篇 |
2013年 | 2979篇 |
2012年 | 3878篇 |
2011年 | 4257篇 |
2010年 | 2285篇 |
2009年 | 1574篇 |
2008年 | 4146篇 |
2007年 | 4436篇 |
2006年 | 4178篇 |
2005年 | 4081篇 |
2004年 | 3911篇 |
2003年 | 3916篇 |
2002年 | 3830篇 |
2001年 | 3183篇 |
2000年 | 3918篇 |
1999年 | 2322篇 |
1998年 | 796篇 |
1997年 | 676篇 |
1996年 | 540篇 |
1995年 | 445篇 |
1994年 | 429篇 |
1993年 | 411篇 |
1992年 | 609篇 |
1991年 | 601篇 |
1990年 | 572篇 |
1989年 | 611篇 |
1988年 | 510篇 |
1987年 | 504篇 |
1986年 | 472篇 |
1985年 | 517篇 |
1984年 | 501篇 |
1983年 | 380篇 |
1982年 | 366篇 |
1981年 | 300篇 |
1980年 | 293篇 |
1979年 | 415篇 |
1978年 | 298篇 |
1977年 | 308篇 |
1976年 | 294篇 |
1975年 | 314篇 |
1973年 | 304篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
21.
T. S. Lie M. Höfer Ch. Höhnke 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1987,372(1):893-894
Zusammenfassung Bei einem 55jährigen Mann wurde 7 Monate nach orthotoper Lebertransplantation eine Lungentuberkulose diagnostiziert. Die tuberculostatische Therapie erfolgte mit Isoniazid (3 x 0,2 g/Wo) und Ethambutol (1,6 g/d) über 11 Monate. Nach 3 Monaten waren keine Mycobakte rien mehr nachweisbar, und der Patient ist im 3. Jahr nach Transplantation ohne Zeichen einer aktiven Tuberkulose in gutem Gesundheitszustand bei guter Transplantatfunktion. Die Tuberculostatica-Dosierung sollte je nach Metabolisierungsleistung des Transplantats reduziert werden. Bei Beachtung dieses Kardinalpunktes könnte eine Tuberkulose nach Lebertransplantation erfolgreich behandelt werden. 相似文献
22.
F R Ochsendorf H Sch?fer R Milbradt 《Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete》1987,38(7):400-403
In an 80-year-old woman with pemphigus erythematosus, we demonstrated ANA as well as anti-DNA antibodies in the serum. This finding supports the argument that this skin disorder represents a combination of a disease of the pemphigus group with systemic lupus erythematosus. 相似文献
23.
U. Bolm-Audorff S. Brandenburg T. Brüning H. Dupuis R. Ellegast G. Elsner K. Franz H. Grasshoff V. Grosser L. Hanisch B. Hartmann E. Hartung K. G. Hering G. Heuchert M. Jäger J. Krämer Dr. A. Kranig E. Ludolph A. Luttmann A. Nienhaus W. Pieper K.-D. Pöhl T. Remé D. Riede G. Rompe K. Schäfer S. Schilling E. Schmitt F. Schröter A. Seidler M. Spallek M. Weber 《Trauma und Berufskrankheit》2005,7(3):211-252
Occupational diseases Nos. 2108 and 2110 correspond to intervertebral disc-related diseases of the lumbar spine from many years of carrying or lifting heavy loads, occupations in extreme postures of full flexion or oscillation of the whole body when seated, and which compel the cessation of all activities which are or could be the cause for the origin, exacerbation or recurrence of the disease. These occupational diseases came into force at the start of 1993, but there have been considerable problems in their implementation. The present Part I of the contribution is the result of the work of an interdisciplinary study group and contains medical criteria for the assessment of possibly strain-related clinical characteristics and the evaluation of other possible causes. Part II is to be published in Volume 4/2005 and will deal with questions related to forced cessation and to the assessment of the loss of earning ability. Agreement was reached in many areas related to the assessment of occupational claims. This should allow for evidence-based decision making in the future for the occupational diseases Nos. 2108 and 2110. 相似文献
24.
Isabella Sch?ll George Boltz-Nitulescu Erika Jensen-Jarolim 《Journal of controlled release》2005,104(1):1-27
For the treatment of infectious diseases, cancer and allergy, the directed induction of an appropriate immune response is the ultimate goal. Therefore, with the development of pure, often very small proteins, peptides or DNA by molecular biology techniques, the research for suitable adjuvants or delivery systems became increasingly important. Particle formulations are made of a variety of materials, including lipids, proteins or amino acids, polysaccharides, polyacrylic substances or organic acids. Microparticles serve as vehicles and provide a depot for the entrapped or coupled antigen. The release occurs in a pulsatile or continuous manner, a feature, which is well controllable for many particulate systems. Particles attract antigen presenting cells to the administration site, thereby guaranteeing the efficient presentation of the antigen to the immune system. Importantly, particles also protect the entrapped substance. This is especially necessary after oral application to avoid gastric or tryptic breakdown. In this article, the design and construction of different antigen delivery systems and their immune effects, with special focus on the suitability for allergy treatment, are discussed. 相似文献
25.
26.
The galanin peptide family and its three receptors have with compelling evidence been implicated in several high-order physiological disorders. The co-localization with other neuromodulators and the distinct up-regulation during and after pathological disturbances has drawn attention to this neuropeptide family. In the current study we present data on receptor binding and functional response for a novel galanin receptor type 2 (GalR2) selective chimeric peptide, M1145 [(RG)2-N-galanin(2-13)-VL-(P)3-(AL)2-A-amide]. The M1145 peptide shows more than 90-fold higher affinity for GalR2 over GalR1 and a 76-fold higher affinity over GalR3. Furthermore, the peptide yields an agonistic effect in vitro, seen as an increase in inositol phosphate (IP) accumulation, both in the absence or the presence of galanin. The peptide design with a N-terminal extension of galanin(2-13), prevails new insights in the assembly of novel subtype specific ligands for the galanin receptor family and opens new possibilities to apply the galanin system as a putative drug target. 相似文献
27.
Georges Schüler 《International journal of public health》1986,31(1):39-41
This review on air pollution and lung cancer recapitulates the main issues in this field (urban-rural-gradients; experimental data and occupational epidemiology of exposure to PAH; smoking and occupation as confounders). Definite risk increases have been observed in the vicinity of point emission sources. Within Switzerland lung cancer shows an urban/rural gradient in both sexes. The geographical distribution of the male cases can hardly be explained only by the patterns of smoking alone. 相似文献
28.
Effect of impact exercise on bone mineral density in elderly women with low BMD: a population-based randomized controlled 30-month intervention 总被引:4,自引:3,他引:1
Raija Korpelainen Sirkka Keinänen-Kiukaanniemi Jorma Heikkinen Kalervo Väänänen Juha Korpelainen 《Osteoporosis international》2006,17(1):109-118
Evidence of the effect of exercise on bone loss comes mainly from studies in voluntary postmenopausal women, and no population-based, long-term interventions have been performed. The purpose of this population-based, randomized, controlled trial was to determine the effect of long-term impact exercise on bone mass at various skeletal sites in elderly women with low bone mineral density (BMD) at the radius and hip. Participants ( n =160) were randomly assigned to 30 months either of supervised and home-based impact exercise training or of no intervention. The primary outcome measures were femoral neck, trochanter and total hip BMD, and the secondary outcomes were bone density measures at the radius and calcaneum. Outcomes were assessed at baseline, 12 months and 30 months using blinded operators. The analyses were performed on an intention-to-treat analysis. Mean femoral neck and trochanter BMD decreased in the control group [–1.1%, 95% confidence interval (CI) –0.1% to –2.1% and –1.6%, 95% CI –0.4% to –2.7%], while no change occurred in the exercise group. Mean trochanter BMC decreased more in the control group (–7.7%, 95% CI –9.7% to –5.6% vs. –2.9%, 95% CI –5.3 to –0.9). There were six falls that resulted in fractures in the exercise group and 16 in the control group during the 30-month intervention ( P =0.019). A significant bone loss occurred in both groups at the radius and calcaneum. In multivariate analysis, weight gain was associated with increased BMD and BMC at all femur sites both in the exercise group and in the pooled groups. In conclusion, impact exercise had no effect on BMD, while there was a positive effect on BMC at the trochanter. Exercise may prevent fall-related fractures in elderly women with low bone mass.There was no conflict of interest. 相似文献
29.
Prof. Dr. C. Haasen A. Kutzer I. Schäfer 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2010,53(4):267-270
In the past, addiction disorders were considered to be mainly substance use disorders. The main focus has been on dependence disorders. Dependence criteria do not differ substantially in the two main classification systems ICD and DSM, while harmful use (ICD) and abuse (DSM) criteria show much less concordance. Presently diagnostic criteria for behavioral addiction disorders are only available for pathological gambling, however, under the category of disorders of impulse control, while other disorders have to be categorized under disorders not otherwise specified. Evidence of neurobiological similarities implies that future ICD and DSM revisions, in addition to other needed changes, will group behavioral addiction and substance use disorders together. 相似文献
30.
A multiply injured patient’s airway is primarily secured with a laryngeal tube by the responding EMS. For helicopter transfer the flight physician decides not to intubate the patient’s trachea. Mechanical ventilation was performed without complications. 相似文献