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41.
R Savage 《The Journal of hand surgery, European volume》1990,15(1):126-128
A case of fracture-separation of the distal phalanx epiphysis, with complete detachment from soft tissue, is reported and discussed. 相似文献
42.
It is known that the postoptic commissures mediate the interocular transfer of visual discriminations in fish. Our experiments demonstrated that information relating to shape crosses in one of these commissures, the horizontal, whereas a completely separate commissure, the minor, mediates the transfer of information relating to color. Such a clear distinction provides a valuable model for the further study of interhemispheric phenomena. 相似文献
43.
Michael P. Savage M.D. Santiago J. Munoz M.D. Walter M. Herman M.D. Victoria M. Kusiak M.D. 《The American journal of gastroenterology》1987,82(10):1088-1090
Chylous ascites is an uncommon clinical entity associated with lymphatic obstruction usually caused by underlying malignancy. The authors describe a patient with chylous ascites caused by constrictive pericarditis in the absence of mechanical lymphatic obstruction. Pathophysiological mechanisms for the development of chylous ascites in constrictive pericarditis include augmented lymph production and high impedance to lymph drainage caused by central venous hypertension. After pericardiectomy, the patient's ascites and edema resolved. Constrictive pericarditis should be considered a rare but potentially curable cause of chylous ascites. 相似文献
44.
V. MALMSTRÖM K. K. Y. HO J. LUN P. P. L. TAM K. S. E. CHEAH & R. HOLMDAHL 《Scandinavian journal of immunology》1997,45(6):670-677
Collagen type II (CII) induced arthritis (CIA) in mice is an experimental model for rheumatoid arthritis. Induction with non-self (e.g. human) CII induces severe arthritis whereas the mice are less susceptible to induction with self CII (i.e. mouse). To analyse whether an autoimmune response to human CII can develop and is pathogenic the authors have established transgenic mice expressing human CII in cartilage and backcrossed them into two different gene backgrounds susceptible to CIA (DBA/1 and C3H.Q). The transgenic human CII expression was restricted to cartilage and did not disturb cartilage morphology or lead to chondrodystrophy. In addition, development of stress-induced arthritis was not affected by the transgene. The cartilage specific expression of human CII reduced, but did not eliminate, the susceptibility to CIA irrespective of the species source (human, bovine, chick, rat) of CII used for immunization. A common denominator between these heterologous CII in comparison with mouse CII is the previously defined CII 256–270 epitope. An expression level dependent T-cell tolerance was seen in this epitope as well as to the entire CII. However, all human transgenic mouse lines could still mount significant autoreactive T- and B-cell responses. Approximately 10% of the transgenic mice developed arthritis after immunization with human CII. These findings show, therefore, that cartilage-located human CII induce tolerance but can nevertheless be a target for development of arthritis. 相似文献
45.
D. A. Savage S. C. Ng H. S. Howe J. L. F. Ngai C. Darke K. M. Hui 《Tissue antigens》1995,46(3):213-216
46.
West nile virus surveillance in Romania: 1997-2000 总被引:1,自引:0,他引:1
Ceianu CS Ungureanu A Nicolescu G Cernescu C Nitescu L Tardei G Petrescu A Pitigoi D Martin D Ciulacu-Purcarea V Vladimirescu A Savage HM 《Viral immunology》2001,14(3):251-262
In response to the 1996 West Nile (WN) fever epidemic that occurred in Bucharest and southeastern Romania, a surveillance program was established. The surveillance system detected 39 clinical human WN fever cases during the period 1997-2000: 14 cases in 1997, 5 cases in 1998, 7 cases in 1999, and 13 cases in 2000. Thirty-eight of the 39 case-patients lived in the greater Danube Valley of southern Romania, and 1 case-patient resided in the district of Vaslui, located on the Moldavian plateau. The estimated annual case incidence rate for the surveillance area during the period 1997-2000 was 0.95 cases per million residents. Thirty-four cases were serologically confirmed, and 5 cases were classified as probable. Twenty-four case-patients presented with clinical symptoms of meningitis (62%), 12 with meningoencephalitis (31%), 1 with encephalitis (3%), and 2 with febrile exanthema (5%). Five of the 39 cases were fatal (13%). Fourteen case-patients resided in rural areas, and 25 in urban and suburban areas, including 7 case-patients who resided in Bucharest. The ages of case-patients ranged from 8 to 76 years with a median age of 45 years. Twenty-four case-patients were males and 15 were females. Dates of onset of illness occurred from May 24 through September 25, with 82% of onset dates occurring in August and September. Limited entomological surveillance failed to detect WN virus. Retrospective sampling of domestic fowl in the vicinity of case-patient residences during the years 1997-2000 demonstrated seroprevalence rates of 7.8%-29%. Limited wild bird surveillance demonstrated seroprevalence rates of 5%-8%. The surveillance data suggest that WN virus persists focally for several years in poorly understood transmission cycles after sporadic introductions or that WN virus is introduced into Romania at relatively high rates, and persists seasonally in small foci. 相似文献
47.
Influences of conjugal genetic transfer functions of colicin V plasmids on adhesion of Escherichia coli to murine intestinal tissue. 总被引:2,自引:0,他引:2
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Cells of strains of Escherichia coli K-12 291 bearing one of three colicin V plasmids, pF54, pH247, or pF70, were tested in comparison with cells of strain 291 for their ability to adhere to murine intestinal tissue in vitro. The plasmids were either repressed or derepressed in conjugal genetic transfer functions. The strains bearing pF54 and pH247 repressed in transfer functions (pColVF54 luminal diameter r and pColVH247 luminal diameter r) adhered in higher numbers to the murine tissue than did the host strain lacking the plasmid or the strains containing the plasmids with active transfer functions (pColVF54drd and pColVH247drd). The number of cells (CFU) of strain 291(pColVF54 luminal diameter r) adherent to the tissue was related directly to the time of incubation (up to 30 min) and to the number of cells (CFU) to which the tissues were exposed. As indicated by tests for sensitivity to F factor (F)-pilus-specific bacteriophages, the cells of strains bearing the plasmids derepressed for conjugal functions had F pili on their surfaces, while such structures were missing from cells of the parental strain (291) and the strains containing the plasmids in repressed form. This finding was supported by transmission electron microscopy of cells of strain 291, 291(pColVF54 luminal diameter r), and 291(pColVF54drd). F pili could be seen on cells of the latter strain but not on those of the parental strain or the strain bearing pColVF54 luminal diameter r. Pili other than F pili were not seen on cells of the strains bearing pF54 in either form. Strains 291(pColVF70drd) and 291(pColVF70 luminal diameter r) adhered to the tissues in numbers comparable to those of strain 291. Nevertheless, these findings are further evidence that for certain colicin V plasmids (A. M. Nilius and D. C. Savage, Infect. Immun. 43:947-953, 1984), conjugal genetic transfer functions influence properties that may be important in the pathogenesis of invasive E. coli strains. 相似文献
48.
Paul Kruszka Tommy Hu Sungkook Hong Rebecca Signer Benjamin Cogné Betrand Isidor Sarah E. Mazzola Jacques C. Giltay Koen L. I. van Gassen Eleina M. England Lynn Pais Charlotte W. Ockeloen Pedro A. Sanchez‐Lara Esther Kinning Darius J. Adams Kayla Treat Wilfredo Torres‐Martinez Maria F. Bedeschi Maria Iascone Stephanie Blaney Oliver Bell Tiong Y. Tan Marie‐Ange Delrue Julie Jurgens Brenda J. Barry Elizabeth C. Engle Sarah K. Savage Nicole Fleischer Julian A. Martinez‐Agosto Kym Boycott Elaine H. Zackai Maximilian Muenke 《American journal of medical genetics. Part A》2019,179(10):2075-2082
Zinc finger protein 462 (ZNF462) is a relatively newly discovered vertebrate specific protein with known critical roles in embryonic development in animal models. Two case reports and a case series study have described the phenotype of 10 individuals with ZNF462 loss of function variants. Herein, we present 14 new individuals with loss of function variants to the previous studies to delineate the syndrome of loss of function in ZNF462. Collectively, these 24 individuals present with recurring phenotypes that define a multiple congenital anomaly syndrome. Most have some form of developmental delay (79%) and a minority has autism spectrum disorder (33%). Characteristic facial features include ptosis (83%), down slanting palpebral fissures (58%), exaggerated Cupid's bow/wide philtrum (54%), and arched eyebrows (50%). Metopic ridging or craniosynostosis was found in a third of study participants and feeding problems in half. Other phenotype characteristics include dysgenesis of the corpus callosum in 25% of individuals, hypotonia in half, and structural heart defects in 21%. Using facial analysis technology, a computer algorithm applying deep learning was able to accurately differentiate individuals with ZNF462 loss of function variants from individuals with Noonan syndrome and healthy controls. In summary, we describe a multiple congenital anomaly syndrome associated with haploinsufficiency of ZNF462 that has distinct clinical characteristics and facial features. 相似文献
49.
R A Savage 《American journal of clinical pathology》1989,92(3):295-299
Sporadically, hematology analyzers generate grossly erroneous results for one or several parameters of the complete blood count (CBC) because of a characteristic or peculiarity of an individual patient specimen. This article presents three cases of relatively less well-known analytic errors of this sort, falsely elevating white blood cell count and platelet count and decreasing total white blood cell count, as determined on a Coulter Aperture Impedence Analyzer. The type of alteration in the CBC parameters and the instrument histogram abnormalities seen in each of these different types of analytic inaccuracy are discussed. 相似文献
50.
McIlroy SP Vahidassr MD Savage DA Patterson CC Lawson JT Passmore AP 《American journal of medical genetics》1999,88(2):140-144
The epsilon-4 allele of apolipoprotein E (APOE) is associated with increased risk of Alzheimer's disease (AD), but the pathogenic mechanism is unknown. The 5-repeat allele of a CGG repeat polymorphism in the 5' untranslated region of the very low-density lipoprotein receptor (VLDL-R) gene, a receptor for apoE, has been found to be associated with increased risk of AD in a Japanese population. Other groups have been unable to replicate this in American Caucasian populations. A case-control study utilizing a clinically well-defined group of late-onset AD patients (n = 108) and age- and sex-matched control subjects (n = 108) from Northern Ireland was performed to test this association in a relatively homogeneous population. The 9,9 genotype of the VLDL-R was found to be significantly increased in patients compared to controls (P = 0.003; Pcorr = 0.035), leading to an increased risk of AD to subjects with this genotype (OR = 3.9; 95% CI, 1.52-11.25). In contrast to results from the Japanese study, the 5-repeat allele was found to be significantly reduced in the patient group when compared to controls (P = 0.008; Pcorr = 0.047). The results from this study suggest that individuals who have the 9,9 genotype of the VLDL-R gene are at increased risk of AD in Northern Ireland. 相似文献