全文获取类型
收费全文 | 28942篇 |
免费 | 1937篇 |
国内免费 | 217篇 |
专业分类
耳鼻咽喉 | 290篇 |
儿科学 | 1051篇 |
妇产科学 | 837篇 |
基础医学 | 3594篇 |
口腔科学 | 522篇 |
临床医学 | 2921篇 |
内科学 | 6419篇 |
皮肤病学 | 575篇 |
神经病学 | 2920篇 |
特种医学 | 706篇 |
外国民族医学 | 1篇 |
外科学 | 2881篇 |
综合类 | 284篇 |
一般理论 | 41篇 |
预防医学 | 3462篇 |
眼科学 | 495篇 |
药学 | 1776篇 |
1篇 | |
中国医学 | 65篇 |
肿瘤学 | 2255篇 |
出版年
2024年 | 38篇 |
2023年 | 431篇 |
2022年 | 813篇 |
2021年 | 1413篇 |
2020年 | 872篇 |
2019年 | 1124篇 |
2018年 | 1247篇 |
2017年 | 947篇 |
2016年 | 1000篇 |
2015年 | 1099篇 |
2014年 | 1415篇 |
2013年 | 1768篇 |
2012年 | 2557篇 |
2011年 | 2576篇 |
2010年 | 1353篇 |
2009年 | 1160篇 |
2008年 | 1746篇 |
2007年 | 1701篇 |
2006年 | 1564篇 |
2005年 | 1397篇 |
2004年 | 1165篇 |
2003年 | 990篇 |
2002年 | 833篇 |
2001年 | 171篇 |
2000年 | 150篇 |
1999年 | 148篇 |
1998年 | 133篇 |
1997年 | 130篇 |
1996年 | 93篇 |
1995年 | 99篇 |
1994年 | 63篇 |
1993年 | 66篇 |
1992年 | 63篇 |
1991年 | 67篇 |
1990年 | 61篇 |
1989年 | 57篇 |
1988年 | 72篇 |
1987年 | 54篇 |
1986年 | 43篇 |
1985年 | 35篇 |
1984年 | 47篇 |
1983年 | 26篇 |
1982年 | 34篇 |
1981年 | 38篇 |
1980年 | 28篇 |
1979年 | 20篇 |
1978年 | 17篇 |
1974年 | 20篇 |
1973年 | 20篇 |
1972年 | 16篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Luca G. Campana Giuseppe Bianchi Simone Mocellin Sara Valpione Laura Campanacci Antonella Brunello Davide Donati Elisabetta Sieni Carlo R. Rossi 《World journal of surgery》2014,38(4):813-822
Aims
Our aim was to evaluate the activity, toxicity, and feasibility of electrochemotherapy (ECT) in patients with soft-tissue sarcomas (STS).Methods
A two-stage phase II trial was conducted between October 2006 and March 2012. Patients (N = 34) with locally advanced or metastatic STS, unsuitable for standard oncological treatments and with maximum 3-cm deep tumors, received an intravenous bolus of bleomycin (15,000 IU/m2), followed by tumor electroporation according to the European Standard Operating Procedures of ECT. Outcome measures included local response according to response evaluation criteria in solid tumors (RECIST), toxicity and tumor control. Feasibility measures included the accuracy of electrode placement and the intensity of electric current flowing in tumor tissue.Results
Median tumor size was 4.0 cm (range 2–12). Objective response, assessed on 71 target lesions, was 92.2 % (complete 32.3, 95 % CI 28–64). A total of 15 patients received up to four cycles due to incomplete response, but re-treatment did not significantly improve outcome (p = 0.205). After a median follow-up of 19.3 months, 2-year local control rate was 72.5 %. Median time to local failure (N = 11 patients) was 5.1 months. Tumor response (p = 0.041) and control (p = 0.047) correlated with histological grading. Relevant toxicity consisted of G3 skin ulceration and soft tissue necrosis (35 and 23 % of patients, respectively), although this was manageable on an outpatient basis. The accuracy of electrode placement was 47.1 %, and the adequacy of electroporative current 85.3 %.Conclusions
ECT may represent an active and safe treatment to achieve local control in advanced STS patients with symptomatic disease. Future research challenges include the improvement of electrode placement and voltage delivery together with the containment of soft tissue toxicity. 相似文献992.
Sara E. Murray Priya R. Pathak Sarah C. Schaefer Herbert Chen Rebecca S. Sippel 《World journal of surgery》2014,38(3):542-548
Background
The aim of the present study was to investigate the incidence of sleep disturbance and insomnia in patients with primary hyperparathyroidism (PHPT), and to evaluate the effect of parathyroidectomy.Methods
A questionnaire was prospectively administered to adult patients with PHPT who underwent curative parathyroidectomy over an 11-month period. The questionnaire, administered preoperatively and 6 months postoperatively, included the Insomnia Severity Index (ISI) and eight additional questions regarding sleep pattern. Total ISI scores range from 0 to 28, with >7 signifying sleep difficulties and scores >14 indicating clinical insomnia.Results
Of 197 eligible patients undergoing parathyroidectomy for PHPT, 115 (58.3 %) completed the preoperative and postoperative questionnaires. The mean age was 60.0 ± 1.2 years and 80.0 % were women. Preoperatively, 72 patients (62.6 %) had sleep difficulties, and 29 patients (25.2 %) met the criteria for clinical insomnia. Clinicopathologic variables were not predictive of clinical insomnia. There was a significant reduction in mean ISI score after parathyroidectomy (10.3 ± 0.6 vs 6.2 ± 0.5, p < 0.0001). Postoperatively, 79 patients (68.7 %) had an improved ISI score. Of the 29 patients with preoperative clinical insomnia, 21 (72.4 %) had resolution after parathyroidectomy. Preoperative insomnia patients had an increase in total hours slept after parathyroidectomy (5.4 ± 0.3 vs 6.1 ± 0.3 h, p = 0.02), whereas both insomnia patients and non-insomnia patients had a decrease in the number of awakenings (3.7 ± 0.4 vs 1.9 ± 0.2 times, p = 0.0001).Conclusions
Sleep disturbances and insomnia are common in patients with PHPT, and the majority of patients will improve after curative parathyroidectomy. 相似文献993.
Francesco Boccardo M.D. Ph.D. Federico Casabona M.D. Franco DeCian M.D. Daniele Friedman M.D. Federica Murelli M.D. Maria Puglisi M.D. Corrado C. Campisi M.D. Lidia Molinari M.D. Stefano Spinaci M.D. Sara Dessalvi M.D. Corradino Campisi M.D. Ph.D. F.A.C.S. 《Microsurgery》2014,34(6):421-424
Breast cancer‐related lymphedema (LE) represents an important morbidity that jeopardizes breast cancer patients' quality of life. Different attempts to prevent LE brought about improvements in the incidence of the pathology but LE still represents a frequent occurrence in breast cancer survivors. Over 4 years ago, Lymphatic Microsurgical Preventing Healing Approach (LYMPHA) was proposed and long‐term results are reported in this study. From July 2008 to December 2012, 74 patients underwent axillary nodal dissection for breast cancer treatment together with LYMPHA procedure. Volumetry was performed preoperatively in all patients and after 1, 3, 6, 12 months, and once a year. Lymphoscintigraphy was performed in 45 patients preoperatively and in 30 also postoperatively after at least over 1 year. Seventy one patients had no sign of LE, and volumetry was coincident to preoperative condition. In three patients, LE occurred after 8–12 months postoperatively. Lymphoscintigraphy showed the patency of lymphatic‐venous anastomoses at 1–4 years after operation. LYMPHA technique represents a successful surgical procedure for primary prevention of arm LE in breast cancer patients. © 2014 Wiley Periodicals, Inc. Microsurgery 34:421–424, 2014. 相似文献
994.
995.
The actual incidence of empyema thoracis is still increasing worldwide and remains a clinical challenge with significant impact on public health; early recognition and prompt evaluation are of prime importance. Despite a lack of standardization of treatments, management should be planned according to stage, avoiding delays on referral. Exudative empyema (stage I) should be treated by aspiration or tube thoracostomy. Fibrinopurulent empyema (stage II) can be treated effectively by video-assisted thoracic surgery. Debridement and decortication are the main components of surgical treatment of stage III empyema. It is worthwhile to assess most cases by video-assisted thoracoscopy. 相似文献
996.
997.
998.
Iñigo Gabilondo MD Elena H. Martínez‐Lapiscina MD Eloy Martínez‐Heras MSc Elena Fraga‐Pumar BO Sara Llufriu MD Santiago Ortiz MD Santiago Bullich PhD Maria Sepulveda MD Carles Falcon PhD Joan Berenguer MD Albert Saiz MD Bernardo Sanchez‐Dalmau MD Pablo Villoslada MD 《Annals of neurology》2014,75(1):98-107
999.
Chiara Bertossi Matteo Cassina Luca De Palma Marilena Vecchi Sara Rossato Irene Toldo Marta Donà Alessandra Murgia Clementina Boniver Stefano Sartori 《Brain & development》2014
Introduction: Duplications of 14q12 encompassing FOXG1 gene have been recently associated with developmental delay, severe speech impairment, epilepsy, aspecific neuroimaging findings and minor dysmorphisms. Aim and methods: In order to refine the epileptic phenotype associated with 14q12 duplications, we have performed a review of the electroclinical picture of the patients reported to date in the literature, adding a new personal case. A comprehensive set of clinical and instrumental data (with a particular focus on the electroclinical aspects including seizure type, age of onset, EEG at onset and after antiepileptic therapy, drug efficacy) has been taken into account. Results: 9/14 patients carrying 14q12 duplications developed seizures, all in the first months of life. Most of them developed infantile spasms (8/9 epileptic patients) and presented hypsarrhythmia or modified hypsarrhythmia on EEG. After therapy 5/9 patients became seizure free and 3/9 present a good seizure control. At last available follow up, 2/3 of the epileptic patients displayed an almost normal EEG, or a quite organized background activity, with diffuse or focal (mostly temporal) slowing. Conclusions: The review of the available data allowed to recognize a common epileptic core, characterized by early onset, age dependent epileptic encephalopathy with infantile spasms and typical, atypical or modified hypsarrhythmia. Antiepileptic therapy soon led to a good or complete control of seizures with a nearly normal background activity in most patients. 相似文献
1000.
Katherine A O’Donnell Hélène Gaudreau Sara Colalillo Meir Steiner Leslie Atkinson Ellen Moss Susan Goldberg Sherif Karama Stephen G Matthews John E Lydon Patricia P Silveira Ashley D Wazana Robert D Levitan Marla B Sokolowski James L Kennedy Alison Fleming Michael J Meaney 《Revue canadienne de psychiatrie》2014,59(9):497-508