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21.
Halileh S Abu-Rmeileh N Watt G Spencer N Gordon N 《Maternal and child health journal》2008,12(5):606-612
The objective of this cross sectional study is to look at determinants of birth weight and their association with the gender
of the baby in 2,795 full term children living in the occupied Palestinian territory, derived from a stratified random sample
of 2,994 households in the West Bank and 2,234 households in the Gaza Strip. The response rate was 85%. Multivariable analysis
using analysis of variance for mixed models showed that sex and birth order, maternal age and education and to a lesser extent
region were determinants of birth weight for all children. The effect of maternal education on birth weight differed for female
and male infants, tending to be relatively unchanged for male infants and with mean birth weights increasing with maternal
education in female infants. The effect of birth order differed by maternal age, with mean birth weight increasing with maternal
age for first and second births; but being unaffected by maternal age for infants of birth order greater than two. We conclude
that birth weight is influenced by common biological determinants across cultures, but is also influenced by social, ethnic,
and environmental factors that are culture specific, of which some might be gender related.
相似文献
Samia HalilehEmail: |
22.
Samia S Islam Sandy Neargarder Shraddha B Kinger Joshua T Fox-Fuller Robert D Salazar Alice Cronin-Golomb 《上海精神医学》2022,35(3)
BackgroundParkinson’s disease (PD) is associated with perceived stigma and affects quality of life (QoL). Additional health conditions may influence these consequences of PD.AimsThis study assessed the impact of health conditions on perceived stigma and QoL in persons with PD. We hypothesised that individuals with more health conditions would report more stigma and poorer QoL. We also examined the contributions of demographic and clinical characteristics to the correlations between health conditions and perceived stigma/QoL.MethodsWe identified 196 eligible participants from the Boston University Online Survey Study of Parkinson’s Disease and examined their health history, performance on multiple stigma measures, and scores on the 39-item Parkinson’s Disease Questionnaire assessing QoL.ResultsAt least one health condition was reported by 79% of the sample, with a median of 2 and a range of 0–7 health conditions. More perceived stigma and poorer QoL were associated with thyroid disease, depression, anxiety, and the total number of health conditions. These correlations were related to younger age, less education, and earlier disease onset. Other health conditions (high blood pressure, back/leg surgery, headache, cancer/tumours, and heart disease) were not significantly correlated with stigma or QoL.ConclusionsHaving more health conditions, or thyroid disease, depression, or anxiety, was associated with more perceived stigma and poorer QoL, with younger age, less education, and earlier disease onset affecting the associations. It is important to consider the burden of health conditions and how they affect persons with PD with specific clinical characteristics. 相似文献
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Eduardo Alexandre Loth Samia Khalil Biazim José Henrique Fermino Ferreira dos Santos Rosana Puccia Rosimeire Costa Brancalh?o Lucinéia de Fátima Chasco Rinaldo Ferreira Gandra Rita de Cássia Garcia Sim?o Marcello Fabiano de Franco 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(3):259-264
Paracoccidioidomycosis (PCM) is caused by the dimorphic fungus
Paracoccidioides brasiliensis (Pb) and corresponds to prevalent
systemic mycosis in Latin America. The aim of the present work was to evaluate the
dose response effect of the fungal yeast phase for the standardization of an
experimental model of septic arthritis. The experiments were performed with groups of
14 rats that received doses of 103, 104 or 105
P. brasiliensis (Pb18) cells. The fungi were injected in 50 µL of
phosphate-buffered saline (PBS) directly into the knee joints of the animals. The
following parameters were analyzed in this work: the formation of swelling in knees
infused with yeast cells and the radiological and anatomopathological alterations,
besides antibody titer by ELISA. After 15 days of infection, signs of inflammation
were evident. At 45 days, some features of damage and necrosis were observed in the
articular cartilage. The systemic dissemination of the fungus was observed in 11% of
the inoculated animals, and it was concluded that the experimental model is able to
mimic articular PCM in humans and that the dose of 105 yeast cells can be
used as standard in this model. 相似文献
25.
An animal component free medium that promotes the growth of various animal cell lines for the production of viral vaccines 总被引:1,自引:0,他引:1
IPT-AFM is a proprietary animal component free medium that was developed for rabies virus (strain LP 2061) production in Vero cells. In the present work, we demonstrated the versatility of this medium and its ability to sustain the growth of other cell lines and different virus strains. Here, three models were presented: Vero cells/rabies virus (strain LP 2061), MRC-5 cells/measles virus (strain AIK-C) and BHK-21 cells/rabies virus (strain PV-BHK21). The cell lines were first adapted to grow in IPT-AFM, by progressive reduction of the amount of serum in the culture medium. After their adaptation, BHK-21 cells grew in suspension by forming clumps, whereas MRC-5 cells remained adherent. Then, kinetics of cell growth were studied in agitated cultures for both cell lines. In addition, kinetics of virus replication were investigated. 相似文献
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Samia M Larivière KE Rochon MH Hibbert BM Basak A Trudeau VL 《General and comparative endocrinology》2004,139(3):198-205
The secretory vesicle protein secretogranin-II (SgII), a precursor for the bioactive peptide secretoneurin, is expressed at all levels of the goldfish reproductive axis, including the hypothalamus, pituitary and ovaries. These findings led us to hypothesize that SgII is involved in reproduction and is physiologically regulated. We investigated the effects of different sex steroids on pituitary SgII expression throughout the seasonal reproductive cycle of the female goldfish, as well as the effects of GnRH and testosterone on pituitary LHbeta subunit, GH, and SgII expression in sexually recrudescent female fish using northern blot analysis. We demonstrated that SgII expression levels vary seasonally, with levels being highest in winter and lowest in spring. Sex steroids did not alter SgII expression at any of the time periods studied. In sexually mature goldfish, injection of a GnRH agonist stimulated the expression of LHbeta and SgII specifically in the pars distalis but not the neurointermediate lobe of the pituitary. Although testosterone alone did not alter the expression of either of these genes, it did abolish the stimulatory effects of GnRH on both LHbeta and SgII expression. This represents the first study where testosterone is shown to modulate SgII expression in the pituitary. 相似文献