全文获取类型
收费全文 | 338篇 |
免费 | 23篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 8篇 |
妇产科学 | 5篇 |
基础医学 | 55篇 |
口腔科学 | 18篇 |
临床医学 | 27篇 |
内科学 | 70篇 |
皮肤病学 | 1篇 |
神经病学 | 30篇 |
特种医学 | 4篇 |
外科学 | 57篇 |
综合类 | 17篇 |
预防医学 | 26篇 |
眼科学 | 2篇 |
药学 | 22篇 |
中国医学 | 2篇 |
肿瘤学 | 17篇 |
出版年
2023年 | 2篇 |
2022年 | 5篇 |
2021年 | 12篇 |
2020年 | 4篇 |
2019年 | 7篇 |
2018年 | 10篇 |
2017年 | 7篇 |
2016年 | 7篇 |
2015年 | 4篇 |
2014年 | 12篇 |
2013年 | 20篇 |
2012年 | 16篇 |
2011年 | 22篇 |
2010年 | 13篇 |
2009年 | 9篇 |
2008年 | 17篇 |
2007年 | 22篇 |
2006年 | 26篇 |
2005年 | 17篇 |
2004年 | 15篇 |
2003年 | 9篇 |
2002年 | 13篇 |
2001年 | 10篇 |
2000年 | 12篇 |
1999年 | 5篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1995年 | 4篇 |
1993年 | 1篇 |
1992年 | 3篇 |
1991年 | 4篇 |
1990年 | 5篇 |
1989年 | 8篇 |
1988年 | 3篇 |
1987年 | 4篇 |
1986年 | 1篇 |
1985年 | 7篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1972年 | 1篇 |
1971年 | 3篇 |
1970年 | 1篇 |
1966年 | 2篇 |
排序方式: 共有363条查询结果,搜索用时 15 毫秒
31.
On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog 总被引:1,自引:14,他引:1
下载免费PDF全文
![点击此处可从《The Journal of clinical investigation》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Eduardo Slatopolsky Sali Caglar J. P. Pennell Dennis D. Taggart Janet M. Canterbury Eric Reiss Neal S. Bricker 《The Journal of clinical investigation》1971,50(3):492-499
Healthy adult dogs were subjected to stepwise reduction of nephron population so as to create the transition from normal renal function to advanced renal insufficiency. Studies were performed at each level of renal function. Glomerular filtration rate (GFR), renal phosphate clearance, and serum radioimmunoassayable parathyroid hormone (PTH) levels were measured. Two groups of animals were studied. In one, phosphorous intake was maintained at 1200 mg/day. As GFR declined, fractional phosphate excretion rose reciprocally, and PTH levels increased over 20-fold. In the second group, phosphorous intake was maintained at less than 100 mg/day. As GFR fell, fractional phosphate excretion changed little, and no increment in PTH levels occurred. The data suggest that the control system regulating phosphate excretion contributes importantly to the pathogenesis of secondary hyperparathyroidism in advancing renal insufficiency. 相似文献
32.
OPTN p.Met468Arg and ATXN2 intermediate length polyQ extension in families with C9orf72 mediated amyotrophic lateral sclerosis and frontotemporal dementia
下载免费PDF全文
![点击此处可从《American journal of medical genetics. Part B, Neuropsychiatric genetics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
33.
Abdulbari Bener Abdulla A. Al-Ansari Mahmoud Zirie Abdulla O. A. A. Al-Hamaq 《International urology and nephrology》2009,41(4):777-784
Objective
The aim of this study was to determine the prevalence of infertility in Qatari men with Diabetes Mellitus (T2DM) and to examine the association between T2DM and infertility. 相似文献34.
Mhd Baraa Habib Mohamed Abdelrazek Sali Alatasi Mouhand F. H. Mohamed Hamda Ali Mohamad Khair Hamad 《Clinical Case Reports》2021,9(8)
Pheochromocytoma can present with right hypochondrial pain, elevated liver enzymes, and a misleading appearance on ultrasound scan mimicking hepatic mass due to the proximity of adrenal masses to the liver. 相似文献
35.
36.
Saad J. Taj-Aldeen Nasser Al-Ansari Sittana El Shafei Jacques F. Meis Ilse Curfs-Breuker Bart Theelen Teun Boekhout 《Journal of clinical microbiology》2009,47(6):1791-1799
Trichosporon species have been reported as emerging pathogens and usually occur in severely immunocompromised patients. In the present work, 27 clinical isolates of Trichosporon species were recovered from 27 patients. The patients were not immunocompromised, except for one with acute myeloid leukemia. Sequence analysis revealed the isolation of Trichosporon dohaense Taj-Aldeen, Meis & Boekhout sp. nov., with CBS 10761T as the holotype strain, belonging to the Ovoides clade. In the D1-D2 large-subunit rRNA gene analysis, T. dohaense is a sister species to T. coremiiforme, and in the internal transcribed spacer analysis, the species is basal to the other species of this clade. Molecular identification of the strains yielded 17 T. asahii, 3 T. inkin, 2 T. japonicum, 2 T. faecale, and 3 T. dohaense isolates. The former four species exhibited low MICs for five antifungal azoles but showed high MICs for amphotericin B. T. dohaense demonstrated the lowest amphotericin B MIC (1 mg/liter). For the majority of T. asahii isolates, amphotericin B MICs were high (MIC at which 90% of isolates were inhibited [MIC90], ≥16 mg/liter), and except for fluconazole (MIC90, 8 mg/liter), the azole MICs were low: MIC90s were 0.5 mg/liter for itraconazole, 0.25 mg/liter for voriconazole, 0.25 mg/liter for posaconazole, and 0.125 mg/liter for isavuconazole. The echinocandins, caspofungin and anidulafungin, demonstrated no activity against Trichosporon species.Trichosporon species are yeast-like fungi, widely distributed in nature and commonly isolated from soil and other environmental sources, which have been involved in a variety of opportunistic infections and have been recognized as emerging fungal pathogens in immunocompromised hosts (19, 79, 80). Disseminated Trichosporon infections are potentially life-threatening and are often fatal in neutropenic patients (7, 22). Although uncommon, pathogenic species of this genus have been reported increasingly, mostly in patients with malignant diseases (3, 6, 9, 10, 11, 20, 32, 44, 47, 48, 63, 77), neonates (18, 56, 84), a bone marrow transplant recipient (22), a solid organ transplant recipient (50), and patients with human immunodeficiency virus (34, 35, 46). Trichosporon has also been reported to cause fungemia (5, 9, 25, 29, 30, 33, 53, 62). Members of the genus Trichosporon have occasionally been implicated as nail pathogens (16, 28, 74) and in subcutaneous infections (66). Trichosporon is considered an opportunistic agent, and therefore, recovery of Trichosporon species capable of growing at 37°C, especially from immunocompromised patients, should be regarded as potentially significant. Several reports have addressed the difficulty of identifying Trichosporon to the species level by physiological and biochemical characteristics (2, 64); therefore, molecular methods based on the sequencing of the internal transcribed spacer (ITS) have been developed (15, 69, 71, 72).In the present paper, we report the isolation of Trichosporon species from clinical specimens over a 4-year period in Qatar, the poor performance of biochemical identification methods, the significance of molecular identification, and the antifungal susceptibility data for the isolates. While investigating the molecular identification of Trichosporon species, we found three strains that do not match any of the published strains in the literature. We describe this organism as Trichosporon dohaense Taj-Aldeen, Meis & Boekhout, sp. nov., the name proposed for this species. 相似文献
37.
38.
Carvalho MA Marsillac SM Karchin R Manoukian S Grist S Swaby RF Urmenyi TP Rondinelli E Silva R Gayol L Baumbach L Sutphen R Pickard-Brzosowicz JL Nathanson KL Sali A Goldgar D Couch FJ Radice P Monteiro AN 《Cancer research》2007,67(4):1494-1501
Germ line inactivating mutations in BRCA1 confer susceptibility for breast and ovarian cancer. However, the relevance of the many missense changes in the gene for which the effect on protein function is unknown remains unclear. Determination of which variants are causally associated with cancer is important for assessment of individual risk. We used a functional assay that measures the transactivation activity of BRCA1 in combination with analysis of protein modeling based on the structure of BRCA1 BRCT domains. In addition, the information generated was interpreted in light of genetic data. We determined the predicted cancer association of 22 BRCA1 variants and verified that the common polymorphism S1613G has no effect on BRCA1 function, even when combined with other rare variants. We estimated the specificity and sensitivity of the assay, and by meta-analysis of 47 variants, we show that variants with <45% of wild-type activity can be classified as deleterious whereas variants with >50% can be classified as neutral. In conclusion, we did functional and structure-based analyses on a large series of BRCA1 missense variants and defined a tentative threshold activity for the classification missense variants. By interpreting the validated functional data in light of additional clinical and structural evidence, we conclude that it is possible to classify all missense variants in the BRCA1 COOH-terminal region. These results bring functional assays for BRCA1 closer to clinical applicability. 相似文献
39.
The results of this study suggest that infection with beta-glucuronidase active bacteria is the initial event
in the nucleation of primary bile duct stones (PBDS).PBDS from five patients were morphologically fragile and “earthy” with alternating light and dark
brown pigment layers with no evidence of a distinct central nucleus that may have been reminiscent of a
different structure. Chemically, calcium bilirubinate and calcium palmitate were prominent throughout
their structure. All bile duct biles had a positive culture and were always associated with at least one
bacterial species which was beta-glucuronidase active. Moreover, fragments of PBDS nuclear areas had
positive cultures that were comparable with those present in their individual bile duct bile. Microscopic
examination of bile showed abundant precipitation of calcium bilirubinate granules in all samples.Thus, bile duct bile infection with beta-glucuronidase active bacteria (e.g. E. coli, C. perfringens)
appears to be a key factor in PBDS pathogenesis, having a precursor role, rather than being a
consequence. Bile stasis is likely to be a co-factor which must have a supportive role in subsequent stone
growth. 相似文献
40.