Effects of the Interaction of the ANKK1/DRD2 TaqIA and HTR2C Cys23Ser Polymorphisms on Approach Motivation in Schizophrenia Patients and Healthy People

Neuroscience and Behavioral Physiology - Objective. To assess the association of the DRD2 gene and its interaction with the HTR2C gene with the characteristics of the hedonistic and activatory...     

水体中克雷伯菌属的分布及其在水源性急性肠道感染中的价值

俄罗斯不同气候地区不同功能水体中克雷伯菌属广泛分布。克雷伯菌属可见于遭受生物、化学污染的集中供水的地表水源,无防护的地下蓄水层,缺乏有效清洁、消毒系统的饮用水。研究表明,水体中的克雷伯菌属具有致病性和毒性,对现代药物和消毒剂(氯、紫外线)具有抗性,很容易穿透进入地下蓄水层。克雷伯菌属细菌有很强的致病性(粘附力、侵袭力、磷酸酯酶、卵磷脂酶、脱氧核糖核酸酶、溶血活性),含有致病性遗传标记cnf-1。克雷伯菌属(100 CFU/dm³)可引起急性肠道感染。在不检测总大肠菌群的情况下,检测水体尤其是饮用水中的克雷伯菌属,可以评估所用水的流行病学危险。     

重组腺病毒bcl-xs基因对人卵巢癌裸鼠移植瘤作用的研究

目的 观察重组腺病毒bcl-xs基因（adv-bcl-xs基因,简称bcl-xs基因）对人卵巢癌裸鼠移植瘤的生长抑制和荷瘤裸鼠生存率的影响。为卵巢癌的基因治疗提供实验基础。方法 采用以复制缺陷型腺病毒bcl-xs基础感染的人胚肾细胞,使bcl-xs基因对NUTU-19细胞的生长抑制作用并检测其病毒滴度后,将bxl-xs基因导入人卵巢癌裸鼠移植瘤中,观察bcl-xs基因对腹水的生长抑制作用,计算裸鼠的生存时间,并观察bcl-xs基因对裸鼠全身和局部的毒副作用。电镜观察bcl-xs基因的病毒颗粒,以免疫细胞化学染色测定bcl-xs基因表达情况。结果 bcl-xs基因可在人胚肾细胞内扩增,对NUTU-19细胞有抑制和杀伤作用。并在裸鼠体内呈过度表达,使裸鼠腹水形成的时间由5-10d延长至11-23d,裸鼠平均生存时间由24d延长至39d,bcl-xs基因对裸鼠全身和局部无明显毒副作用。结论 bcl-xs基因导入人卵巢癌裸鼠移植肿瘤,能延缓腹水形成,延长裸鼠的生存时间,为卵巢癌的基因治疗提供了一种新方法。     

Overview on the Evaluation of the Elastic Properties of Non-Carbon Nanotubes by Theoretical Approaches

Low-dimensional structures, such as nanotubes, have been the focus of research interest for approximately three decades due to their potential for use in numerous applications in engineering and technology. In addition to extensive investigation of carbon nanotubes, those composed of elements other than carbon, the so-called non-carbon nanotubes, have also begun to be studied, since they can be more suitable for electronic and optical nano-devices than their carbon counterparts. As in the case of carbon nanotubes, theoretical (numerical and analytical) approaches have been established predominantly to study non-carbon nanotubes. So far, most of work has dealt with the investigation of the structural and electrical properties of non-carbon nanotubes, paying less attention to the evaluation of their mechanical properties. As the understanding of the mechanical behaviour of the constituents is fundamental to ensure the effective performance of nanotube-based devices, this overview aims to analyse and systematize the literature results on the elastic properties of inorganic non-carbon nanotubes.     

Copolymers prepared on the basis of isopropenyl derivatives of o-carborane

New mono- and bifunctional isopropenyl derivatives of o-carborane were synthesized according to the Witting reaction, from the corresponding acetyl derivatives and methylenetriphenylphosphorane. The radical copolymerization with methyl methacrylate was investigated and thermal and thermomechanical characteristics of the obtained copolymers were studied. In copolymers prepared on the basis of a monofunctional carborane-containing monomer, the increase of glass transition temperature takes practically a linear course with increasing boron content. In crosslinked copolymers the presence of o-carborane fragments leads to the widening of the glass transition temperature range, predominantly at low temperatures, irrespective of the type of bifunctional monomer used.     

Program for interpreting acid-base disorders and assessing blood oxygenation

The paper describes a program for the interpretation of deviations in the acid-base state (AAS) and the estimation of the blood oxygenation levels. The program was developed for the Iskra-226 microcomputer and is intended for a direct measurement of the gas composition of the blood. The program makes it possible to calculate the AAS and the blood oxygenation levels (20 parameters), to estimate the AAS deviation type and the degree of its compensation, it accumulates and stores the patient data, keeps records of case histories.