武警某部军人慢性前列腺炎样症状的调查研究

目的 了解武警军人慢性前列腺炎样症状的发病情况并研究在部队特殊环境下的发病因素,为进一步探讨其发病机制与针对性治疗提供依据.方法 应用自制问卷和美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)对301名武警某部军人进行调查.结果 (1)慢性前列腺炎样症状阳性率为23.6％.(2)单因素分析结果,年龄、BMI、...     

PET研究慢性疲劳综合征中枢机制现状

慢性疲劳综合征(CFS)与中枢系统功能异常密切相关,常伴认知困难、焦虑抑郁及痛觉改变等,目前尚无特异性诊断方法。PET可为研究CFS中枢系统异常提供重要参考依据。本文就PET研究CFS中枢机制现状进行综述。     

糖尿病黄斑水肿的诊断和治疗进展

糖尿病黄斑水肿(DME)的发病率正逐渐上升,其作为导致糖尿病患者视力不可逆丧失的主要原因,一直受到医学研究者的关注。目前,在应用诸如光学相干断层扫描和抗血管内皮生长因子等针对DME的诊疗方法的同时,多种新兴的解决方案正在被研发。因此,本文将对现有DME的诊断和治疗方案进行总结讨论,以期为未来DME诊疗标准的统一奠定基础。     

Nursing of adverse effects in patients treated with liver resection plus sorafenib for hepatocellular carcinoma： 5 cases report

There were very few reports of adverse effects in patients treated by liver resection in combination with sorafenib. We present 5 cases of hepatocellular carcinoma treated with liver resection plus sorafenib , trying to observing the adverse effects and seeking the nursing options to the adverse effects. The 5 patients were all males, and the mean age was (38.6±13.4) years. Tumor sizes were (6.7±2.2) cm, and liver function was Child-Pugh class A. Diagnosis of Hepatocellular carcinoma (HCC) was confirmed by postoperative pathology. During the follow-ups, all the 5 patients had different degrees of adverse effects, of which 5 patients had diarrhea, 3 had hand-foot skin reaction, 1 had hypertension and 1 had alopecie. Diarrhea seems common in these patients, and it appeared early after treatment. For those patients with adverse effects, management measures were given immediately, including nursing interventions and some medicines. Psychological and symptomatic nursing guidance can help patients overcome the adverse effects. No patients suffered dose reduction or treatment discontinuation.     

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??OBJECTIVE To assess a panel of 9 human monoclonal antibodies against human erythropoietin (EPO) with defined characteristics (non-neutralizing, neutralizing, affinities) for suitability for EPO antibody assays. METHODS A multi-center collaborative study involving three different laboratories and different assay platforms was carried out. Direct ELISA was used to test the affinities of the samples by Shenyang Sunshine pharmaceutical Co., Ltd and National Institutes for Food and Drug control,while indirect ELISA was used by Xiamen amoytop biotech Co., Ltd. The neutralizing assays were performed using UT-7 cell line by all the three laboratories. RESULTS The properties of the 9 human monoclonal antibodies against human erythropoietin were assessed efficiently by all the three laboratories using different METHODS.CONCLUSION It is suggested that the EPO antibody panel is established to enable the evaluation of the performance of different EPO antibody assays and thus the selection of appropriate assay for clinical use.     

三种输尿管上段结石治疗方法的临床比较

目的 探讨治疗上段输尿管结石的最佳方法.方法 回顾分析我院2006年5月至2009年5月101例输尿管结石患者的外科治疗方法.A组应用小切口手术即输尿管上段切开取石术22例;B组应用微创经皮肾输尿管镜碎石术41例;C组应用后腹腔镜下输尿管切开取石术38例.分析比较三种方法在输尿管上段结石治疗中的差异.结果 A、B、C三...     

产科护士职业倦怠状况的调查与分析

目的了解产科护士职业倦怠的状况。方法采用Maslach职业倦怠量表对149名产科护士进行调查，并与杭州市常模进行比较。结果108名产科护士职业倦怠检出率为72．5％；情感耗竭、去人格化维度明显高于杭州市常模。结论产科护士职业倦怠发生率较高，应引起护理管理者重视。     

柚皮素β-环糊精包合物的制备及对模型大鼠脉络膜新生血管形成的抑制作用

目的:制备柚皮素β-环糊精(β-CD)包合物,研究其对模型大鼠脉络膜新生血管(CNV)形成的抑制作用。方法:采用饱和溶液法制备柚皮素β-CD包合物;利用红外光谱、X射线衍射法对包合物进行表征分析,测定柚皮素的含量与水溶解度;通过氪激光复制大鼠CNV模型,15只BN大鼠随机均分为溶媒对照(等容溶媒)组、柚皮素(20 mg/kg)组与柚皮素β-CD包合物(97.4 mg/kg)组,腹腔注射给药,每天1次,连续4周。以脉络膜铺片法测量大鼠CNV面积。结果:柚皮素和β-CD形成了稳定的包合物,柚皮素β-CD包合物中柚皮素质量分数为20.53%,柚皮素在水中的溶解度为单体的11.8倍。与溶媒对照组比较,柚皮素组、柚皮素β-CD包合物组大鼠CNV面积减小,差异有统计学意义(P<0.01或P<0.05);与柚皮素组比较,柚皮素β-CD包合物组大鼠CNV面积减小,差异有统计学意义(P<0.05)。结论:柚皮素和β-CD包合后,水溶性增加;柚皮素β-CD包合物抑制模型大鼠CNV形成的作用优于柚皮素。     

110例药品不良反应汇总分析

目的通过对我院2012年收集的110例不良反应报告汇总,分析药物不良反应(ADR)发生情况、发生特点及相关因素;通过对ADR上报范围及趋势的分析,进一步促进我院ADR监测工作的进步。方法采用病例回顾性研究的方法,总结药品不良反应发生特点及上报特点。结果 14岁以下及45岁以上年龄段占比例较高;男性与女性ADR发生率大致相同;静脉滴注给药途径引起ADR的比例较高;涉及的药品以抗肿瘤药物、抗菌药物和中成药制剂居多;2012年ADR上报数量及质量较往年显著提高,药师上报ADR数量居首。结论药品不良反应发生率受人口学因素、给药途径、药品差异等多种因素影响,临床应用中应以患者为中心,充分发挥医、护、药多种职业的协同优势,加强防患意识,做好药品不良反应的监测和上报工作,为临床合理用药提供支持。     

刘开运教授小儿推拿取穴精要

刘开运(1918-2003),我国著名中医推拿专家,湖南省首批审定50名名老中医之一.曾担任全国推拿学会副主任委员,湖南省推拿学会主任委员.出身中医世家,幼承家学,融汉、苗医药于一炉,独树一旗,是国内唯一精通中医、草医、推拿的名老中医,尤以独具特色的小儿推拿而蜚声于国内外.他的"刘氏小儿推拿术"在全国自成一派,且临床疗效奇特.本文从刘老的小儿推拿临床取穴特色方面进行临床经验总结,以便更好的继承和发展——"刘氏小儿推拿"这一特殊技术.现将刘老小儿推拿取穴经验总结为4个方面报道如下.