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91.
TAKASHI NAKANO YOSHIKI SHIMONO KENJI SUGIYAMA HIDEHIRO NISHIHARA MASAMUNE HIGASHIGAWA YOSHIHIRO KOMADA MASAHIRO ITO MINORU SAKURAI AZUSA YOSHIDA KENJI KITAMURA TOSHIAKI IHARA HITOSHI KAMIYA MINORU HAMAZAKI TETSUTARO SATA 《Pediatrics international》1996,38(3):212-217
Measles is often fatal for immunocompromised hosts. Protective immunity against measles has been studied but is still not completely understood. Recently, five cases of measles were encountered in immunocompromised children. Two of these were allogeneic bone marrow transplanted cases (one common variable immunodeficiency and one severe aplastic anemia) in remission, one Wilms' tumor case in remission, one hepatoblastoma case after cytotoxic therapy at disease onset and one exaggerating hemophagocytic syndrome case with suppressed natural killer cell activity. Clinical symptoms, laboratory findings and the immunologic backgrounds of these five patients were investigated. One of the patients, an 8 year old boy with hemophagocytic syndrome, died of giant cell pneumonia which was confirmed in the section of necropsy lung specimen. Two other patients who received allogeneic bone marrow transplants were not immune to measles, despite their own and their donors' immunizations. Their clinical symptoms were rather severe but both patients recovered and have remained seropositive for as long as 13 months. This fatality from measles is the first reported in a patient with hemophagocytic syndrome. Suppressed natural killer cell activity may be a poor prognostic factor. Also, secondary immunization failure for measles can occur in bone marrow transplanted patients with rather severe clinical symptoms. 相似文献
92.
目的 探讨盆腔后腹膜无缝合法在妇癌淋巴结清扫术的应用价值。方法 对218例包括淋巴结清除术在内的各妇癌手术病例进行回顾分析,比较了盆腔后腹膜缝合组与无缝合组的术前、术中、术后状况以及并发症的发生率。结果 盆腔后腹膜无缝合法,能减少引流管保留天数,缩短发热期间和降低淋巴囊肿的发生率。结论 (1)盆腔淋巴结清扫术后,后腹膜的缝合可以省略;(2)后腹膜无缝合有降低淋巴囊肿发生的可能性。 相似文献
93.
HIDEHIKO MATSUBAYASHI TAKAHIRO SUZUKI TADASHI ARAI AKANE KONDO TOSHITAKA SUGI SHUN-ICHIRO IZUMI TSUNEHISA MAKINO TAKASHI HOSAKA YOKO SUGIYAMA 《American journal of reproductive immunology (New York, N.Y. : 1989)》2001,46(5):318-322
PROBLEM: An increase in natural killer (NK)-cell activity has been observed in women with unexplained recurrent miscarriages. Because of the many similarities between infertility and early pregnancy loss patients, we investigated whether infertile women had raised NK-cell activity. METHOD OF STUDY: We tested 94 infertile women who, in spite of treatment, were unable to conceive for 6 or more months. NK-cell activity was measured by using a chromium-51 release cytotoxicity assay. with K562 human myeloid leukemia cells as targets. RESULTS: NK-cell activity of the infertile group (mean +/- SD; 40.2%+/-14.7) was significantly higher than the control group (31.5%+/-11.9, P < 0.0001). The increased NK-cell activity was not associated with age, infertile duration, depression scores, treated hyperprolactinemia, or treated endometriosis. CONCLUSIONS: In certain patients, elevated NK-cell activity may be considered an independent risk factor for infertility. 相似文献
94.
Haruo SHINTAKU Shigeo KURE Toshihiro OHURA Yoshiyuki OKANO Misao OHWADA Naruji SUGIYAMA Nobuo SAKURA Ichiro YOSHIDA Makoto YOSHINO Yohichi MATSUBARA Ken SUZUKI Kikumaro AOKI Teruo KITAGAW 《中国当代儿科杂志》2005,7(4):301-304
目的:四氢生物蝶呤(BH4)可以使BH4缺乏症病人的血液苯丙氨酸水平正常化,但是对苯丙酮酸尿症(PKU)病人无效。最近在新生儿PKU筛查中发现了对BH4有反应的轻度PKU患者。本研究将探讨BH4和苯丙氨酸羟化酶(PAH)基因突变在对BH4有反应的轻度PKU和轻度高苯丙酸血症(HPA)患者中的作用。方法:对经新生儿PKU筛查中发现的生物蝶呤代谢正常的轻度HPA患者,进行单次(10mg/kg)、4次、1周[20 mg/(kg·d)]的BH4口服负荷试验及长期BH4治疗,评估其对BH4口服负荷试验的反应性。结果:在单剂量BH4口服负荷试验中,典型PKU患者的血苯丙氨酸水平没有降低。在单剂量BH4口服负荷试验中血苯丙氨酸水平下降超过20%的患者,在4次BH4口服负荷试验中下降亦超过20%。1周BH4负荷试验确认在单剂量和4次BH4负荷试验中表现出弱反应性的病人对BH4有反应。许多患轻度PKU和轻度HPA且有R241C基因位点的病人,都对BH4治疗有反应。在无BH4反应性的典型PKU病人中未发现R241C、P407S和A373T基因突变。结论:1周BH4负荷试验用于诊断BH4反应性PAH缺乏症最为有效。等位基因R241C、P407S和A373T与轻度HPA和轻度PKU病人具有H4反应性有关。BH4治疗是针对轻度HPA和轻度PKU的一种新颖、有效的药物治疗,有望代替限制苯丙氨酸饮食的方法。 相似文献
95.
Yoshinobu KAMIO Naoto SAKAI Tetsuro SAMESHIMA Goro TAKAHASHI Shinichiro KOIZUMI Kenji SUGIYAMA Hiroki NAMBA 《Neurologia medico-chirurgica》2014,54(8):606-611
Postoperative visual outcome is a major concern in transsphenoidal surgery (TSS).
Intraoperative visual evoked potential (VEP) monitoring has been reported to have
little usefulness in predicting postoperative visual outcome. To re-evaluate its
usefulness, we adapted a high-power light-stimulating device with electroretinography
(ERG) to ascertain retinal light stimulation. Intraoperative VEP monitoring was
conducted in TSSs in 33 consecutive patients with sellar and parasellar tumors under
total venous anesthesia. The detectability rates of N75, P100, and N135 were
94.0%, 85.0%, and 79.0%, respectively. The mean latencies and
amplitudes of N75, P100, and N135 were 76.8 ± 6.4 msec and 4.6 ± 1.8
μV, 98.0 ± 8.6 msec and 5.0 ± 3.4 μV, and 122.1
± 16.3 msec and 5.7 ± 2.8 μV, respectively. The amplitude was
defined as the voltage difference from N75 to P100 or P100 to N135. The criterion for
amplitude changes was defined as a > 50% increase or 50%
decrease in amplitude compared to the control level. The surgeon was immediately
alerted when the VEP changed beyond these thresholds, and the surgical manipulations
were stopped until the VEP recovered. Among the 28 cases with evaluable VEP
recordings, the VEP amplitudes were stable in 23 cases and transiently decreased in 4
cases. In these 4 cases, no postoperative vision deterioration was observed. One
patient, whose VEP amplitude decreased without subsequent recovery, developed vision
deterioration. Intraoperative VEP monitoring with ERG to ascertain retinal light
stimulation by the new stimulus device was reliable and feasible in preserving visual
function in patients undergoing TSS. 相似文献
96.
Tomokazu AOKI Ryo NISHIKAWA Kazuhiko SUGIYAMA Naosuke NONOGUCHI Noriyuki KAWABATA Kazuhiko MISHIMA Jun-ichi ADACHI Kaoru KURISU Fumiyuki YAMASAKI Teiji TOMINAGA Toshihiro KUMABE Keisuke UEKI Fumi HIGUCHI Tetsuya YAMAMOTO Eiichi ISHIKAWA Hideo TAKESHIMA Shinji YAMASHITA Kazunori ARITA Hirofumi HIRANO Shinobu YAMADA Masao MATSUTANI for the NPC- study group 《Neurologia medico-chirurgica》2014,54(4):290-301
Carmustine (BCNU) implants (Gliadel® Wafer, Eisai Inc., New Jersey, USA) for the treatment of malignant gliomas (MGs) were shown to enhance overall survival in comparison to placebo in controlled clinical trials in the United States and Europe. A prospective, multicenter phase I/II study involving Japanese patients with MGs was performed to evaluate the efficacy, safety, and pharmacokinetics of BCNU implants. The study enrolled 16 patients with newly diagnosed MGs and 8 patients with recurrent MGs. After the insertion of BCNU implants (8 sheets maximum, 61.6 mg BCNU) into the removal cavity, various chemotherapies (including temozolomide) and radiotherapies were applied. After placement, overall and progression-free survival rates and whole blood BCNU levels were evaluated. In patients with newly diagnosed MGs, the overall survival rates at 12 months and 24 months were 100.0% and 68.8%, and the progression-free survival rate at 12 months was 62.5%. In patients with recurrent MGs, the progression-free survival rate at 6 months was 37.5%. There were no grade 4 or higher adverse events noted due to BCNU implants, and grade 3 events were observed in 5 of 24 patients (20.8%). Whole blood BCNU levels reached a peak of 19.4 ng/mL approximately 3 hours after insertion, which was lower than 1/600 of the peak BCNU level recorded after intravenous injections. These levels decreased to less than the detection limit (2.00 ng/mL) after 24 hours. The results of this study involving Japanese patients are comparable to those of previous studies in the United States and Europe. 相似文献
97.
98.
Fuyuki TATENO Ryuji SAKAKIBARA Megumi SUGIYAMA Masahiko KISHI Emina OGAWA Osamu TAKAHASHI Masashi YANO Tomoyuki UCHIYAMA Tatsuya YAMAMOTO Yohei TSUYUZAKI 《Lower urinary tract symptoms.》2012,4(1):41-44
Objective: To investigate lower urinary tract function in spinocerebellar ataxia type 6 (SCA6). Methods: We recruited, without bias, nine SCA6 patients with a mean cytosine‐adenine‐guanine repeat length of 24.3 (21–26, normal <18). They were four men, five women; mean age 58.6 years; mean disease duration 8.2 years. We performed a urinary symptom questionnaire and a urodynamics. Results: Urinary symptoms were observed in five of nine patients (56%) and urinary frequency in three of nine patients (33%), and none had urinary retention. Urodynamic abnormalities included detrusor overactivity in one (11%) and weak detrusor on voiding in two, but none had postvoid residual urine. Sphincter electromyography revealed, while mild in degree, neurogenic change in five of the eight patients (63%) on whom the test was performed. Conclusion: We observed urinary frequency in 33%; detrusor overactivity in only 11%; and neurogenic change in the sphincter electromyography in 63% of our nine SCA6 patients. These findings might be relevant to the cerebellar and spinal cord pathologies of this disease. 相似文献
99.
Kuniko TSUNOYAMA Ryuji SAKAKIBARA Osamu TAKAHASHI Megumi SUGIYAMA Tomoyuki UCHIYAMA Fuyuki TATENO Masahiko KISHI Yohei TSUYUSAKI Tatsuya YAMAMOTO Kazunari TANABE 《Lower urinary tract symptoms.》2013,5(1):17-22
Objectives: During bladder filling, the bladder starts to sense it and the sensation steadily increases. However, little is known concerning volume‐sensory correlation in normal bladder and pressure‐sensory correlation during detrusor overactivity (DO). We aimed to real‐time assess bladder sensation in normal bladder and DO using a five‐grade measure. Methods: We enrolled 74 normal individuals and 87 patients with DO (51 terminal, 36 phasic). During slow bladder filling, we instructed individuals to indicate sensation in five grades: 1, first sensation; 2, obviously greater than 1 but less than 3; 3, first desire to void when he or she usually goes to toilet; 4, obviously greater than 3 but less than 5; and 5, strong desire to void. We also instructed individuals to report other sensations, such as pain. Results: The five‐grade measure is feasible in all participants, showing a volume and pressure‐ sensory correlation. Among the five grades, grade 0 to 1 was the longest, followed by grade 4 to 5, in all participants. Grade 0 to 1 in phasic DO and grade 4 to 5 in terminal and phasic DO were shorter than those in normal bladder (P < 0.05). Eighty‐six percent of patients with DO reported that the rapidly increased sensory grade is akin to urinary urgency in daily life. Conclusion: The five‐grade measure is feasible to assess a volume and pressure‐sensory correlation. Using this measure the sensory grade rapidly increased during DO compared with normal bladder, and 86% of the patients with DO reported that it is akin to urinary urgency in daily life. 相似文献