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排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
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Lesley A. Mathews Griner Rajarshi Guha Paul Shinn Ryan M. Young Jonathan M. Keller Dongbo Liu Ian S. Goldlust Adam Yasgar Crystal McKnight Matthew B. Boxer Damien Y. Duveau Jian-Kang Jiang Sam Michael Tim Mierzwa Wenwei Huang Martin J. Walsh Bryan T. Mott Paresma Patel William Leister David J. Maloney Christopher A. Leclair Ganesha Rai Ajit Jadhav Brian D. Peyser Christopher P. Austin Scott E. Martin Anton Simeonov Marc Ferrer Louis M. Staudt Craig J. Thomas 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(6):2349-2354
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995.
Christopher T. Ryan Adriana Santiago Nabil Tariq Harveen K. Lamba 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2020,47(4):284
Bariatric surgery helps many morbidly obese patients lose substantial weight. However, few data exist on its long-term safety and effectiveness in patients who also have continuous-flow left ventricular assist devices and in whom heart transplantation is contemplated. We retrospectively identified patients at our institution who had undergone ventricular assist device implantation and subsequent laparoscopic sleeve gastrectomy from June 2015 through September 2017, and we evaluated their baseline demographic data, preoperative characteristics, and postoperative outcomes.Four patients (3 men), ranging in age from 32 to 44 years and in body mass index from 40 to 57, underwent sleeve gastrectomy from 858 to 1,849 days after left ventricular assist device implantation to treat nonischemic cardiomyopathy. All had multiple comorbidities.At a median follow-up duration of 42 months (range, 24–47 mo), median body mass index decreased to 31.9 (range, 28.3–44.3) at maximal weight loss, with a median percentage of excess body mass index lost of 72.5% (range, 38.7%–87.4%). After achieving target weight, one patient was listed for heart transplantation, another awaited listing, one was kept on destination therapy because of positive drug screens, and one regained weight and remained ineligible.On long-term follow-up, laparoscopic sleeve gastrectomy appears to be safe and feasible for morbidly obese patients with ventricular assist devices who must lose weight for transplantation consideration. Additional studies are warranted to evaluate this weight-loss strategy after transplantation and immunosuppression. 相似文献
996.
Victor A. Chow MD Joseph G. Rajendran MD Darrell R. Fisher Frederick R. Appelbaum MD Ryan D. Cassaday MD Paul S. Martin MD Leona A. Holmberg MD PhD Theodore A. Gooley PhD Philip A. Stevenson MS John M. Pagel MD PhD Damian J. Green MD Oliver W. Press MD PhD Ajay K. Gopal MD 《American journal of hematology》2020,95(7):775-783
Radiation is the most effective treatment for localized lymphoma, but treatment of multifocal disease is limited by toxicity. Radioimmunotherapy (RIT) delivers tumoricidal radiation to multifocal sites, further augmenting response by dose-escalation. This phase II trial evaluated high-dose RIT and chemotherapy prior to autologous stem-cell transplant (ASCT) for high-risk, relapsed or refractory (R/R) B-cell non-Hodgkin lymphoma (NHL). The primary endpoint was progression free survival (PFS). Secondary endpoints were overall survival (OS), toxicity, and tolerability. Patients age < 60 years with R/R NHL expressing CD20 were eligible. Mantle cell lymphoma (MCL) patients could proceed to transplant in first remission. Patients received I-131-tositumomab delivered at ≤25Gy to critical normal organs, followed by etoposide, cyclophosphamide and ASCT. A group of 107 patients were treated including aggressive lymphoma (N = 29), indolent lymphoma (N = 45), and MCL (N = 33). After a median follow-up of 10.1 years, the 10-year PFS for the aggressive, indolent, and MCL groups were 62%, 64%, 43% respectively. The 10-year OS for the aggressive, indolent, and MCL groups were 61%, 71%, 48% respectively. Toxicities were similar to standard conditioning regimens and non-relapse mortality at 100 days was 2.8%. Late myeloid malignancies were seen in 6% of patients. High-dose I-131-tositumomab, etoposide and cyclophosphamide followed by ASCT appeared feasible, safe, and effective in treating NHL, with estimated PFS at 10-years of 43%-64%. In light of novel cellular therapies for R/R NHL, high-dose RIT-containing regimens yield comparable efficacy and safety and could be prospectively compared. 相似文献
997.
Vella Michael A. Dumas Ryan P. Chreiman Kristen Wasser Thomas Smith Brian P. Reilly Patrick M. Seamon Mark J. Shiroff Adam 《Journal of thrombosis and thrombolysis》2020,49(3):420-425
Journal of Thrombosis and Thrombolysis - Little is known about the association between epidural catheters (EC) and venous thromboembolism (VTE) in trauma. We sought to study this association and... 相似文献
998.
Randolph D. Hubach Brian Dodge Gabriel Goncalves David Malebranche Michael Reece Barbara Van Der Pol Omar Martinez Phillip W. Schnarrs Ryan Nix J. Dennis Fortenberry 《Archives of sexual behavior》2014,43(4):707-717
Although frequently cited as being at high risk for HIV/STI transmission, little is known about behaviorally bisexual men’s patterns and experiences of condom use and nonuse with male and female sexual partners. Using a variety of recruitment techniques informed by a Community Advisory Committee, a total of 77 behaviorally bisexual men were recruited from Indianapolis, Indiana to participate in semi-structured interviews focused on sexual health. Qualitative data were collected containing detailed information on their patterns and experiences of condom use and nonuse with both male and female partners. Participants described numerous commonly reported barriers for consistent condom use, as well as distinct bisexual-specific barriers. The majority reported consistent condom use with male and female casual partners, but many who did not use condoms described doing so in the context of ongoing relationships. In addition, participants provided reasons for condom use and nonuse that varied based on the gender of the partner and the type of relationship with the partner. Future interventions focused on increasing condom use among behaviorally bisexual men should take into account the unique complexities of gender and relationship configurations in this distinct population. 相似文献
999.
Stephen M. Shortell Ph.D. M.P.H. M.B.A. Sean R. McClellan Ph.D. Patricia P. Ramsay M.P.H. Lawrence P. Casalino M.D. Ph.D. Andrew M. Ryan Ph.D. M.A. Kennon R. Copeland Ph.D. M.S. 《Health services research》2014,49(5):1519-1536
Objective
To provide the first nationally based information on physician practice involvement in ACOs.Data Sources/Study Setting
Primary data from the third National Survey of Physician Organizations (January 2012–May 2013).Study Design
We conducted a 40-minute phone survey in a sample of physician practices. A nationally representative sample of practices was surveyed in order to provide estimates of organizational characteristics, care management processes, ACO participation, and related variables for four major chronic illnesses.Data Collection/Extraction Methods
We evaluated the associations between ACO participation, organizational characteristics, and a 25-point index of patient-centered medical home processes.Principal Findings
We found that 23.7 percent of physician practices (n = 280) reported joining an ACO; 15.7 percent (n = 186) were planning to become involved within the next 12 months and 60.6 percent (n = 717) reported no involvement and no plans to become involved. Larger practices, those receiving patients from an IPA and/or PHO, those that were physician-owned versus hospital/health system-owned, those located in New England, and those with greater patient-centered medical home (PCMH) care management processes were more likely to have joined an ACO.Conclusions
Physician practices that are currently participating in ACOs appear to be relatively large, or to be members of an IPA or PHO, are less likely to be hospital-owned and are more likely to use more care management processes than nonparticipating practices. 相似文献1000.