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排序方式: 共有1901条查询结果,搜索用时 9 毫秒
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Marijke Span Marike Hettinga Leontine Groen-van de Ven Jan Jukema Ruud Janssen Myrra Vernooij-Dassen 《Disability and rehabilitation》2018,40(12):1410-1420
Purpose: The aim of this study was at gaining insight into the participatory design approach of involving people with dementia in the development of the DecideGuide, an interactive web tool facilitating shared decision-making in their care networks.Method: An explanatory case study design was used when developing the DecideGuide. A secondary analysis focused on the data gathered from the participating people with dementia during the development stages: semi-structured interviews (n?=?23), four focus group interviews (n?=?18), usability tests (n?=?3), and a field study (n?=?4). Content analysis was applied to the data.Results: Four themes showed to be important regarding the participation experiences of involving people with dementia in research: valuable feedback on content and design of the DecideGuide, motivation to participate, perspectives of people with dementia and others about distress related to involvement, and time investment.Conclusions: People with dementia can give essential feedback and, therefore, their contribution is useful and valuable. Meaningful participation of people with dementia takes time that should be taken into account. It is important for people with dementia to be able to reciprocate the efforts others make and to feel of significance to others.
- Implications for Rehabilitation
People with dementia can contribute meaningfully to the content and design and their perspective is essential for developing useful and user-friendly tools.
Participating in research activities may contribute to social inclusion, empowerment, and quality of life of people with dementia.
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Mete A Jalving R van Oost BA van Dijk JE Marx JJ 《Blood cells, molecules & diseases》2005,34(2):151-156
Hereditary hemochromatosis (HH) is a frequent genetic disease of older subjects of northern European descent. It is characterized by increased iron absorption and severe iron overloading in parenchymal organs. A similar disturbance of iron metabolism occurs in specific animal species in captivity. To address the key features leading to high absorption and thus to iron overload in these animals, we have studied the two iron transport proteins DMT1 and Ireg1 in the best-known susceptible species, the mynah bird. Here, we show that these birds have a high expression of DMT1 in the duodenum and also a strikingly high expression of Ireg1 along the whole small intestine. We believe that the iron accumulation in susceptible species only occurs in captivity because of a genotypic adaptation to their natural environment, where contrary to captivity, dietary iron is hardly available. The Caucasian population carrying mutations leading to iron overload today may have also benefited from the genetic advantage of up-regulating iron transport millennia ago, when dietary iron was scarce. 相似文献
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Impact of the International Continence Society (ICS) report on the standardisation of terminology in nocturia on the quality of reports on nocturia and nocturnal polyuria: a systematic review 下载免费PDF全文
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Vrieze A Van Nood E Holleman F Salojärvi J Kootte RS Bartelsman JF Dallinga-Thie GM Ackermans MT Serlie MJ Oozeer R Derrien M Druesne A Van Hylckama Vlieg JE Bloks VW Groen AK Heilig HG Zoetendal EG Stroes ES de Vos WM Hoekstra JB Nieuwdorp M 《Gastroenterology》2012,143(4):913-916.e7
Alterations in intestinal microbiota are associated with obesity and insulin resistance. We studied the effects of infusing intestinal microbiota from lean donors to male recipients with metabolic syndrome on the recipients' microbiota composition and glucose metabolism. Subjects were assigned randomly to groups that were given small intestinal infusions of allogenic or autologous microbiota. Six weeks after infusion of microbiota from lean donors, insulin sensitivity of recipients increased (median rate of glucose disappearance changed from 26.2 to 45.3 μmol/kg/min; P < .05) along with levels of butyrate-producing intestinal microbiota. Intestinal microbiota might be developed as therapeutic agents to increase insulin sensitivity in humans; www.trialregister.nl; registered at the Dutch Trial Register (NTR1776). 相似文献
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