全文获取类型
收费全文 | 23824篇 |
免费 | 2163篇 |
国内免费 | 62篇 |
专业分类
耳鼻咽喉 | 187篇 |
儿科学 | 888篇 |
妇产科学 | 711篇 |
基础医学 | 3286篇 |
口腔科学 | 554篇 |
临床医学 | 3204篇 |
内科学 | 4334篇 |
皮肤病学 | 276篇 |
神经病学 | 2214篇 |
特种医学 | 636篇 |
外科学 | 2376篇 |
综合类 | 490篇 |
一般理论 | 42篇 |
预防医学 | 3362篇 |
眼科学 | 435篇 |
药学 | 1425篇 |
中国医学 | 7篇 |
肿瘤学 | 1622篇 |
出版年
2023年 | 143篇 |
2022年 | 210篇 |
2021年 | 457篇 |
2020年 | 288篇 |
2019年 | 435篇 |
2018年 | 511篇 |
2017年 | 402篇 |
2016年 | 406篇 |
2015年 | 514篇 |
2014年 | 681篇 |
2013年 | 1062篇 |
2012年 | 1445篇 |
2011年 | 1546篇 |
2010年 | 848篇 |
2009年 | 724篇 |
2008年 | 1397篇 |
2007年 | 1456篇 |
2006年 | 1467篇 |
2005年 | 1406篇 |
2004年 | 1261篇 |
2003年 | 1188篇 |
2002年 | 1273篇 |
2001年 | 386篇 |
2000年 | 362篇 |
1999年 | 392篇 |
1998年 | 293篇 |
1997年 | 222篇 |
1996年 | 194篇 |
1995年 | 188篇 |
1994年 | 202篇 |
1993年 | 186篇 |
1992年 | 205篇 |
1991年 | 220篇 |
1990年 | 231篇 |
1989年 | 226篇 |
1988年 | 199篇 |
1987年 | 183篇 |
1986年 | 202篇 |
1985年 | 204篇 |
1984年 | 177篇 |
1983年 | 160篇 |
1982年 | 159篇 |
1981年 | 128篇 |
1980年 | 144篇 |
1979年 | 151篇 |
1978年 | 140篇 |
1977年 | 124篇 |
1975年 | 103篇 |
1974年 | 105篇 |
1973年 | 114篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
Jun Gu Yang O Huh Feng Jiang Nancy P Caraway Jorge E Romaguera Tanweer M Zaidi Ricardo L Fernandez Huazhong Zhang Issa F Khouri Ruth L Katz 《Modern pathology》2004,17(5):553-560
Mantle cell lymphoma is non-Hodgkin's B-cell lymphoma characterized by the t(11;14)(q13;q32) translocation. Peripheral blood involvement of mantle cell lymphoma is usually associated with a poor prognosis and therefore, its identification is clinically important. In this study, we performed cyclin D1/IgH-probe fusion fluorescence in situ hybridization analysis on 223 peripheral blood samples: 185 from 125 mantle cell lymphoma patients, and 38 normal controls. The cutoff values for the test were established using normal controls. Flow cytometry on peripheral blood and corresponding bone marrow samples was used to evaluate this test. In all, 26% of the 185 peripheral blood samples and 27% of the 161 corresponding bone marrow samples were flow cytometry positive for mantle cell lymphoma. The mean numbers of single and- double-fusion signals and the mean number of CD5/CD19-positive cells, absolute blood lymphocyte count, and white blood cell count were significantly higher in peripheral blood and corresponding bone marrow samples with mantle cell lymphoma-positive flow cytometry. Double-fusion signals were more specific than single-fusion ones. Fluorescence in situ hybridization was far more likely to be positive for mantle cell lymphoma when the peripheral blood and the corresponding bone marrow samples had positive flow cytometry results or morphology (P<0.01). Our study indicates that cyclin D1/IgH-fusion fluorescence in situ hybridization analysis could be used to determine the presence and character of circulating mantle cell lymphoma cells in peripheral blood, thus enhancing our ability to evaluate leukemic mantle cell lymphoma and minimum residual disease. 相似文献
72.
73.
Lorraine N Clark Eneli Haamer Helen Mejia-Santana Juliette Harris Suzanne Lesage Alexandra Durr Sabine Janin Bs Katja Hedrich Elan D Louis Lucien J Cote Howard Andrews Stanley Fahn Cheryl Waters Blair Ford Steven Frucht William Scott Christine Klein Alexis Brice Hanno Roomere Ruth Ottman Karen Marder 《Movement disorders》2007,22(7):932-937
Parkin mutations account for the majority of familial and sporadic early onset Parkinson's disease (EOPD) cases with a known genetic association. More than 100 mutations have been described in the Parkin gene that includes homozygous, compound heterozygous, and single heterozygous mutations. We have designed a Parkin mutation genotyping array (gene chip) that includes published Parkin sequence variants and allows their simultaneous detection. The chip was validated by screening 85 PD cases and 47 controls previously tested for Parkin mutations. Similar genotyping microarrays have been developed for other genetically heterogeneous diseases including age-related macular degeneration. Here, we show the utility of a genotyping array for Parkinson's disease by analysis of 60 subjects from the Genetic Epidemiology of Parkinson Disease (GEPD) study that includes 15 early-onset PD case probands and 45 relatives. 相似文献
74.
75.
76.
77.
The intra-operative histological assessment of fresh tissue can provide valuable diagnostic information and guide surgical
management, however, even a limited exposure to standard fixation agents can potentially compromise analysis. Defined handling
strategies should exist to facilitate the receipt of all specimens, in their optimal state, by the laboratory. 相似文献
78.
79.
Piper I. R.; Garrioch M. A.; Souter M. J.; Andrews PJD.; Thomson D. 《British journal of anaesthesia》1998,80(5):639-643
Diaspirin cross-linked haemoglobin (DCLHb) is a new oxygen carrying blood
substitute with vasoactive properties. Vasoactive properties may be
mediated via high affinity binding of nitric oxide by the haem moiety.
Using a rodent model of head injury combined with ischaemia, we studied the
effects of DCLHb on cerebral blood flow (CBF) and intracranial pressure
(ICP). Twenty anaesthetized rats were allocated randomly to receive
treatment with DCLHb 400 mg kg-1 i.v. or placebo (oncotically matched
plasma protein substitute 4.5% i.v.). To produce diffusely increased ICP,
after a severe weight drop injury, all animals underwent a 30-min period of
bilateral carotid ligation combined with a period of induced hypotension.
After reperfusion, DCLHb or placebo was infused and the animals
instrumented for measurement of intraventricular ICP and CBF in the region
of the sensorimotor cortex using the hydrogen clearance technique. Mean
arterial pressure (MAP), ICP, cerebral perfusion pressure (CPP) (CPP = MAP
- ICP) and CBF were measured 4 h after injury in all animals. DCLHb
significantly reduced ICP from mean 13 (SEM 2) to 3 (1) mm Hg (P <
0.001), increased CPP from 52 (8) to 95 (6) mm Hg (P < 0.001) and
increased CBF from 21 (2) to 29 (2) ml 100 g-1 min-1 (P = 0.032). We
conclude that DCLHb improved CPP without a reduction in CBF in a rodent
model of post-traumatic brain swelling.
相似文献
80.
R. Wilson J. H. McKillop M. MacLean J. J. Walker W. D. Fraser† C. Gray† F. Dryburgh† J. A. Thomson 《Clinical endocrinology》1992,37(4):331-334
OBJECTIVES: There is considerable controversy in the literature as to the cause of hyperemesis gravidarum. The aim of this project was to measure a range of thyroid hormone levels in a group of hyperemetic pregnant women. PATIENTS: The study was carried out in 10 first trimester pregnant women with hyperemesis gravidarum. All had been admitted to hospital due to the severity of their symptoms. Fifty age matched, healthy first trimester pregnant women were used as controls. MEASUREMENTS: Blood samples from the women were analysed for total T3 (TT3), total T4 (TT4), free T4 (FT4), TSH, thyrotrophin receptor antibodies (TRAb), thyroid stimulating antibodies (TSAb) and thyroid microsomal and thyroglobulin antibodies. Human chorionic gonadotrophin (hCG) levels were also measured. RESULTS: While individual patients were found to have some abnormal thyroid function tests the group as a whole showed no consistent pattern of abnormality and did not differ significantly from a group of healthy first trimester pregnant women. hCG levels were also within the normal range in the hyperemetic patients. DISCUSSION: None of the women in this study received any antithyroid medication and their symptoms improved as the pregnancy progressed. These results would suggest that there is no underlying thyroid abnormality in patients with hyperemesis gravidarum. It would appear that neither thyroid hormones, nor hCG contribute to the pathogenesis of the condition. 相似文献