The radiographic manifestations of von Hippel-Lindau disease

The radiographic findings and method of investigation are presented in the retrospective and prospective study of 221 descendents of an individual affected with von Hippel-Lindau disease. Among 42 affected individuals, most of the reported manifestations were found, such as cerebellar hemangioblastoma, retinal angioma, and renal cell carcinoma. A new manifestation, pancreatic carcinoma, was also seen. Although pheochromocytoma is common in some reported families, no cases were found in this group. An organized multidisciplinary approach is necessary to effectively identify and treat individuals affected with this disease.     

The electrolytes in gastric secretion after histamine and Histalog stimulation

Summary and conclusion Twenty-three subjects were subjected to histamine and Histalog stimulation, and the gastric secretions were collected over periods of 2 hours. In the 17 subjects whose data were considered acceptable, a rise in rate of gastric secretion was observed after both types of stimulation. The curve for sodium concentration follow an inverse relationship to that for acid; the curve for total chloride concentration was closely parallel to that for acid. After both types of stimulation, there was a rise in the K concentration.No correlation was observed between the curves for Cl or total acidity and the curve for K.The Histalog (3-beta-aminoethylpyrazole dihidrochloride) used in the study reported here was kindly provided by Eli Lilly & Co., Lndianapolis. Ind. The study was also supported by a grant from Laboratório Torres, São Paulo, Brasil.     

Serological evidence for the alteration of enolase during aging.

Pure enolase isolated from young and old Turbatrix aceti has been compared using immunologic techniques. Antiserum prepared to "young" and "old" enolase, respectively, will completely precipitate either enzyme. However, antiserum prepared to "young" enolase reacts more efficiency with "young" than with "old" than with "old" enzyme and vice versa. A third form of enolase (inactive enolase) is found in homogenates of old organisms. This material yields a pattern of identity with "young" enolase and partial identity with "old" enolase. It also gives rise to specific antibodies which do not react with "young" or "old" enolase. The material appears to accumulate with age. The results indicate a close structural relationship between "young", "old" and inactive enolase.     

Pathology: the evolution of a specialty in American medicine.

The historical evolution of pathology as a full-time specialty in medicine is viewed as a response of pathologists to changes in the level and pattern of demand for their services. The development and decline of morphologic pathology, changes in academic pathology and the evolution of clinical pathology from a medical specialty to an industry with an extensive division of labor are all examined in this perspective. It is shown that pathology as a medical specialty is most successful within a limited range of demand, neither too low to support full-time specialization nor too high to lead to deprofessionalization through routinization of the work activities of pathologists.     

Accelerating effect of ascorbic acid on N-nitrosamine formation and nitrosation by oxyhyponitrite.

The reaction of nitrite ion with ascorbic acid and its effect on the rate of nitrosation of secondary amines have been investigated by differential pulse polarography in aqueous acidic solution. Ascorbic acid shows nonuniform behavior: it accelerates the nitrosation of N-methylaniline between pH 1.00 and 1.95, allows the nitrosation of diphenylamine and iminodiacetonitrile, but inhibits the nitrosation of secondary amines, such as dimethylamine, diethylamine, proline, hydroxyproline, N-methylaminoacetonitrile, N-methylaminopropionitrile, and sarcosine. The nitrosating agent generated by the reaction between ascorbic acid and nitrite ion appears to be oxyhyponitrite ion (N2O3-2).