全文获取类型
收费全文 | 785篇 |
免费 | 40篇 |
国内免费 | 43篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 20篇 |
妇产科学 | 4篇 |
基础医学 | 79篇 |
口腔科学 | 16篇 |
临床医学 | 101篇 |
内科学 | 241篇 |
皮肤病学 | 4篇 |
神经病学 | 29篇 |
特种医学 | 193篇 |
外科学 | 21篇 |
综合类 | 8篇 |
预防医学 | 26篇 |
眼科学 | 1篇 |
药学 | 88篇 |
中国医学 | 1篇 |
肿瘤学 | 32篇 |
出版年
2024年 | 1篇 |
2023年 | 3篇 |
2022年 | 1篇 |
2021年 | 2篇 |
2020年 | 3篇 |
2019年 | 7篇 |
2018年 | 8篇 |
2017年 | 3篇 |
2016年 | 6篇 |
2015年 | 22篇 |
2014年 | 23篇 |
2013年 | 23篇 |
2012年 | 18篇 |
2011年 | 20篇 |
2010年 | 23篇 |
2009年 | 23篇 |
2008年 | 24篇 |
2007年 | 43篇 |
2006年 | 27篇 |
2005年 | 26篇 |
2004年 | 11篇 |
2003年 | 8篇 |
2002年 | 13篇 |
2001年 | 17篇 |
2000年 | 16篇 |
1999年 | 21篇 |
1998年 | 36篇 |
1997年 | 35篇 |
1996年 | 39篇 |
1995年 | 31篇 |
1994年 | 47篇 |
1993年 | 25篇 |
1992年 | 9篇 |
1991年 | 8篇 |
1990年 | 11篇 |
1989年 | 38篇 |
1988年 | 34篇 |
1987年 | 36篇 |
1986年 | 27篇 |
1985年 | 20篇 |
1984年 | 16篇 |
1983年 | 17篇 |
1982年 | 12篇 |
1981年 | 8篇 |
1980年 | 9篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1977年 | 3篇 |
1976年 | 6篇 |
1975年 | 4篇 |
排序方式: 共有868条查询结果,搜索用时 0 毫秒
91.
Waldmann TA; Goldman CK; Bongiovanni KF; Sharrow SO; Davey MP; Cease KB; Greenberg SJ; Longo DL 《Blood》1988,72(5):1805-1816
Human T-cell lymphotropic virus I (HTLV-I)-induced adult T-cell leukemia (ATL) cells constitutively express interleukin-2 (IL-2) receptors identified by the anti-Tac monoclonal antibody (MoAb), whereas normal resting cells do not. This observation provided the scientific basis for a trial of intravenous anti-Tac in the treatment of nine patients with ATL. The patients did not suffer untoward reactions and did not have a reduction in the normal formed elements of the blood, and only one of the nine produced antibodies to the anti-Tac MoAb. Three patients had transient mixed, partial, or complete remissions lasting from 1 to more than 8 months after anti-Tac therapy, as assessed by routine hematologic tests, immunofluorescence analysis of circulating cells, and molecular genetic analysis of HTLV-I provirus integration and of the T-cell receptor gene rearrangement. The precise mechanism of the antitumor effects is unclear; however, the use of a MoAb that prevents the interaction of IL-2 with its receptor on ATL cells provides a rational approach for the treatment of this malignancy. 相似文献
92.
93.
Computed tomographic study of hormone-secreting microadenomas 总被引:1,自引:0,他引:1
Hemminghytt S; Kalkhoff RK; Daniels DL; Williams AL; Grogan JP; Haughton VM 《Radiology》1983,146(1):65
94.
Chloroperoxidase mediated halogenation of phenols 总被引:1,自引:0,他引:1
95.
C Gennari R Toccafondi C M Rotella G Francini M L Brandi E Maioli 《Calcified tissue international》1983,35(3):273-278
In order to evaluate whether or not the action of salmon calcitonin (sCT) at the kidney level could be mediated through specific receptors for the hormone, we have studied the effects of sCT infusions on urinary excretion of cyclic nucleotides in humans. Parallel in vitro studies have been conducted by evaluating the effects of sCT on cyclic nucleotide levels in primary cultures of cortical and medullary human kidney cells. In vivo experiments showed that sCT induced an increase in cGMP in human urine, which was rapid and short-lasting, being superimposable on the increase of urinary excretion of calcium and magnesium. The increase of inorganic phosphate urinary excretion was delayed and appeared to parallel that of urinary cAMP. On the other hand, our in vitro experiments showed that sCT stimulated the guanylate cyclase-cGMP system of human kidney cortical cells at nanomolar concentrations, while higher concentrations of the hormone were required to activate the adenylate cyclase-cAMP system. In addition, sCT was not able to significantly modify the cellular levels of either nucleotide in human kidney medullary cells. Present data demonstrated a direct effect of sCT on human kidney cortical cGMP production, while the efficacy of sCT on the kidney cortex adenylate cyclase-cAMP system appears to be delayed and/or reduced. 相似文献
96.
A new catheter system was used in ten patients (16 infusions) for infusion of chemotherapeutic agents to the sites of malignant gliomas. Thirteen infusions to the supraophthalmic region were successful, as were three infusions to the posterior cerebral region. There were no complications after the infusions. A neurologic complication occurred in one patient in whom two successful supraophthalmic infusions were previously carried out. In this patient the guide wire separated during catheter placement into the posterior cerebral artery. 相似文献
97.
Dave VP; Keefe R; Berger MA; Drbal K; Punt JA; Wiest DL; Alarcon B; Kappes DJ 《International immunology》1998,10(10):1481-1490
CD3delta-deficient (delta degrees) mice are defective in alphabeta T cell
development. Here we explore the capacity of TCR-CD3 signaling complexes
expressed on delta degrees thymocytes to mediate the following functional
outcomes in response to antibody cross-linking: (i) the transition from the
CD4-CD8- to CD4+CD8+ stage, (ii) the transition from the CD4+CD8+ to
CD4+CD8- or CD4-CD8+ stages and (iii) the induction of apoptosis. We
provide evidence that CD3deltaepsilon complexes are dispensable for
mediating the anti-CD3-mediated CD4-CD8- to CD4+CD8+ transition. On the
other hand, CD3delta is critical at the CD4+CD8+ stage. We demonstrate that
CD4+CD8+ thymocytes from delta degrees mice, unlike delta degrees CD4-CD8-
thymocytes and wild-type CD4+CD8+ thymocytes, require prolonged or
consecutive stimuli to elicit functional responses. Depending on the nature
of the secondary stimulus, delta degrees thymocytes can be induced to
undergo apoptosis or preferential maturation to the CD4-CD8+ stage. Taken
together these results indicate that the signaling capacity of the TCR-CD3
complex is noticeably altered in the absence of CD3delta. The essential
role of CD3delta at the CD4+CD8+ stage of development correlates with the
onset of TCRalpha rearrangement, consistent with a critical structural
and/or functional relationship between CD3delta and TCRalpha.
相似文献
98.
99.
To calculate the centre of pressure using piezoelectric force plates mounted on pads, no net tensile stresses may be imposed on the surface of the plate. This condition is violated when stairs are attached to the plates, unless the plates are preloaded. Typical shear forces encountered when climbing stairs were used to determine required preloads of approximately 16.4 N/cm step height. Vertical and horizontal loads were applied at known locations on the steps, and points of application were calculated. Deviations were within ± 3 mm. The effect of point of application inaccuracy on calculated joint moments is considerable. A 2 cm medial shift in the point of application resulted in calculated peak knee abduction/adduction moment errors of 35%. 相似文献
100.
MR mammographic localization. Work in progress 总被引:1,自引:0,他引:1
Hussman K; Renslo R; Phillips JJ; Fischer HJ; Khalkhali I; Braslau DL; Sinow RM 《Radiology》1993,189(3):915