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排序方式: 共有286条查询结果,搜索用时 31 毫秒
111.
112.
Andrew D. Norden Glenn J. Lesser Jan Drappatz Keith L. Ligon Samantha N. Hammond Eudocia Q. Lee David R. Reardon Camilo E. Fadul Scott R. Plotkin Tracy T. Batchelor Jay-Jiguang Zhu Rameen Beroukhim Alona Muzikansky Lisa Doherty Debra Lafrankie Katrina Smith Vida Tafoya Rosina Lis Edward C. Stack Myrna R. Rosenfeld Patrick Y. Wen 《Neuro-oncology》2013,15(7):930-935
Background
Among patients with glioblastoma (GBM) who progress on standard temozolomide, the optimal therapy is unknown. Resistance to temozolomide is partially mediated by O6-methylguanine-DNA methyltransferase (MGMT). Because MGMT may be depleted by prolonged temozolomide administration, dose-intense schedules may overcome resistance.Methods
This was a multicenter, phase 2, single-arm study of temozolomide (75–100 mg/m2/day) for 21 days of each 28-day cycle. Patients had GBM in first recurrence after standard therapy. The primary end point was 6-month progression-free survival (PFS6).Results
Fifty-eight participants were accrued, 3 of whom were ineligible for analysis; one withdrew before response assessment. There were 33 men (61%), with a median age of 57 years (range, 25–79 years) and a median Karnofsky performance score of 90 (range, 60–100). Of 47 patients with MGMT methylation results, 36 (65%) had methylated tumors. There were 7 (13%) partial responses, and PFS6 was only 11%. Response and PFS did not depend on MGMT status; MSH2, MLH1, or ERCC1 expression; the number of prior temozolomide cycles; or the time off temozolomide. Treatment was well tolerated, with limited grade 3 neutropenia (n = 2) or thrombocytopenia (n = 2).Conclusions
Dose-intense temozolomide on this schedule is safe in recurrent GBM. However, efficacy is marginal and predictive biomarkers are needed. 相似文献113.
Silvia Vandini Luigi Corvaglia Rosina Alessandroni Giulia Aquilano Concetta Marsico Marica Spinelli Marcello Lanari Giacomo Faldella 《Italian journal of pediatrics》2013,39(1):1-6
Background
Respiratory Syncytial Virus (RSV) is the most important cause of severe respiratory infections in infants with seasonal epidemics. Environmental factors (temperature, humidity, air pollution) could influence RSV epidemics through their effects on virus activity and diffusion.Methods
We conducted a retrospective study on a paediatric population who referred to our Paediatric Emergency Unit in order to analyze the correlation between weekly incidence of RSV positive cases during winter season in Bologna and meteorological factors and air pollutants concentration.Results
We observed a significant correlation between the incidence of RSV infections and the mean minimum temperature registered during the same week and the previous weeks. The weekly number of RSV positive cases was also correlated to the mean PM10 concentration of the week before.Conclusions
RSV epidemic trend in Bologna (Italy) is related to the mean minimum temperature, and the mean PM10 concentration. 相似文献114.
Bizzaro N Covini G Rosina F Muratori P Tonutti E Villalta D Pesente F Alessio MG Tampoia M Antico A Platzgummer S Porcelli B Terzuoli L Liguori M Bassetti D Brusca I Almasio PL Tarantino G Bonaguri C Agostinis P Bredi E Tozzoli R Invernizzi P Selmi C 《Clinical reviews in allergy & immunology》2012,42(3):288-297
Serum anti-mitochondrial antibodies (AMA) are the serological hallmark of primary biliary cirrhosis (PBC), yet up to 15% of PBC sera are AMA negative at routine indirect immunofluorescence (IIF) while being referred to as ??probable?? cases. The diagnostic role of PBC-specific antinuclear antibodies (ANA) remains to be determined. We will report herein data on the accuracy of new laboratory tools for AMA and PBC-specific ANA in a large series of PBC sera that were AMA-negative at IIF. We will also provide a discussion of the history and current status of AMA detection methods. We included IIF AMA-negative PBC sera (n?=?100) and sera from patients with other chronic liver diseases (n?=?104) that had been independently tested for IIF AMA and ANA; sera were blindly tested with an ELISA PBC screening test including two ANA (gp210, sp100) and a triple (pMIT3) AMA recombinant antigens. Among IIF AMA-negative sera, 43/100 (43%) manifested reactivity using the PBC screening test. The same test was positive for 6/104 (5.8%) control sera. IIF AMA-negative/PBC screen-positive sera reacted against pMIT3 (11/43), gp210 (8/43), Sp100 (17/43), both pMIT3 and gp210 (1/43), or both pMIT3 and Sp100 (6/43). Concordance rates between the ANA pattern on HEp-2 cells and specific Sp100 and gp210 ELISA results in AMA-negative subjects were 92% for nuclear dots and Sp100 and 99% for nuclear rim and gp210. Our data confirm the hypothesis that a substantial part of IIF AMA-negative (formerly coined ??probable??) PBC cases manifest disease-specific autoantibodies when tested using newly available tools and thus overcome the previously suggested diagnostic classification. As suggested by the recent literature, we are convinced that the proportion of AMA-negative PBC cases will be significantly minimized by the use of new laboratory methods and recombinant antigens. 相似文献
115.
Transformation of IGHV4‐34+ hairy cell leukaemia‐variant with U2AF1 mutation into a clonally‐related high grade B‐cell lymphoma responding to immunochemotherapy
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116.
Thaís da Silva Ferreira Maria Inês Barreto Silva Mariana Silva da Costa Karine Scanci da Silva Pontes Flavia Garcia Castro Vanessa Parada Antunes Kelli Trindade de Carvalho Rosina Ana Paula Medeiros Menna Barreto Edison Souza Mrcia Regina Simas Torres Klein 《Clinical transplantation》2019,33(8)
Obesity is associated with increased risk of cardiovascular disease (CVD). Body mass index (BMI) is the most used parameter for obesity screening. However, the evaluation of CVD risk in overweight individuals should include the assessment of body fat distribution and body composition. Renal transplant recipients (RTR) have a high CVD risk and frequently present weight gain and loss of lean mass. The aim of this study was to evaluate body fat distribution and body composition in overweight RTR. This cross‐sectional study was conducted with 86 RTR and 86 hypertensive individuals (comparison group, CG) presenting BMI 25‐35 Kg/m2 and 45‐70 years. Anthropometric evaluation included BMI, waist circumference, waist‐to‐height ratio, and a body shape index. Body composition was evaluated with bioelectrical impedance analysis (BIA). Glomerular filtration rate was estimated (eGFR) by CKD‐EPI equation. RTR group (RTRG) and CG presented similar age and BMI. RTRG when compared to CG presented lower percentage of women and eGFR; higher central adiposity; and lower values of reactance, intracellular water, body cell mass and phase angle, more consistently observed in women. This study suggests that overweight RTR present higher abdominal adiposity and impairment in BIA parameters that are sensitive indicators of impaired membrane integrity, water distribution, and body cell mass. 相似文献
117.
Tommaso Stroffolini Evangelista Sagnelli Caterina Sagnelli Maurizio Russello Massimo De Luca Floriano Rosina Bruno Cacopardo Giuseppina Brancaccio Caterina Furlan Giovanni Battista Gaeta Anna Licata Piero Luigi Almasio behalf of EPACRON study group 《Infection》2017,45(3):277-281
Background
The endemicity of hepatitis delta virus infection in Italy has decreased in the last decades.Aim
To evaluate the current epidemiology of chronic delta infection in Italy and to compare the present findings with the corresponding figures from the previous studies.Methods
A cross-sectional study involving 16 referral centres scattered all over the country in 2014.Results
Out of the 513 hepatitis B surface antigen-positive subjects enrolled, 61 (11.9%) were anti-delta positive, with a sex ratio (M/F) of 2.05. The majority (80.3%) of them was 50 years or older, while the proportion of subjects younger than 30 years of age was as low as 3.3%. No difference was detected by geographical area of residence. The presence of liver cirrhosis was diagnosed in 52.4% of cases. In comparison to previous studies, a further shift towards the oldest age groups and an increasing proportion of subjects having liver cirrhosis among all anti-delta-positive subjects are observed.Conclusions
Currently, hepatitis delta infection mostly affects old people who have an advanced but indolent liver disease, reflecting a survival effect. The defective hepatitis delta virus is near to disappear in the country, where it has been discovered in the second half of 70s.118.
Cejka C Ardan T Sirc J Michálek J Beneš J Brůnová B Rosina J 《Current eye research》2011,36(7):607-613
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