全文获取类型
收费全文 | 2549篇 |
免费 | 152篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 55篇 |
儿科学 | 88篇 |
妇产科学 | 103篇 |
基础医学 | 329篇 |
口腔科学 | 50篇 |
临床医学 | 202篇 |
内科学 | 583篇 |
皮肤病学 | 26篇 |
神经病学 | 257篇 |
特种医学 | 137篇 |
外国民族医学 | 1篇 |
外科学 | 385篇 |
综合类 | 6篇 |
一般理论 | 1篇 |
预防医学 | 170篇 |
眼科学 | 43篇 |
药学 | 178篇 |
中国医学 | 6篇 |
肿瘤学 | 92篇 |
出版年
2023年 | 16篇 |
2022年 | 24篇 |
2021年 | 47篇 |
2020年 | 29篇 |
2019年 | 46篇 |
2018年 | 43篇 |
2017年 | 41篇 |
2016年 | 56篇 |
2015年 | 64篇 |
2014年 | 70篇 |
2013年 | 106篇 |
2012年 | 169篇 |
2011年 | 158篇 |
2010年 | 108篇 |
2009年 | 98篇 |
2008年 | 135篇 |
2007年 | 137篇 |
2006年 | 133篇 |
2005年 | 140篇 |
2004年 | 121篇 |
2003年 | 132篇 |
2002年 | 102篇 |
2001年 | 69篇 |
2000年 | 78篇 |
1999年 | 74篇 |
1998年 | 28篇 |
1997年 | 22篇 |
1996年 | 22篇 |
1995年 | 14篇 |
1994年 | 19篇 |
1993年 | 17篇 |
1992年 | 48篇 |
1991年 | 39篇 |
1990年 | 33篇 |
1989年 | 32篇 |
1988年 | 34篇 |
1987年 | 18篇 |
1986年 | 19篇 |
1985年 | 17篇 |
1984年 | 11篇 |
1983年 | 9篇 |
1982年 | 8篇 |
1980年 | 8篇 |
1979年 | 16篇 |
1978年 | 10篇 |
1976年 | 13篇 |
1973年 | 7篇 |
1971年 | 7篇 |
1970年 | 9篇 |
1967年 | 9篇 |
排序方式: 共有2712条查询结果,搜索用时 187 毫秒
31.
32.
L. Bertin E. Rey G. Pons J. L. Mathiot M. O. Richard P. Chrétien C. Saint-Maurice C. Moran D. Ginisty G. Olive 《European journal of clinical pharmacology》1991,41(3):251-253
Summary. Twelve healthy children in three age groups anaesthetized for minor surgery were given a single oral dose of tiaprofenic acid (3 mg · kg–1) (TA). Seven blood samples and zero to 8 and 8 to 24 h urines were collected. TA concentrations in plasma and urine were measured by HPLC.No significant difference was found between the age groups in the kinetic parameters of TA and no correlation was found between these parameters and age; tmax=2.12h, Cmax=8.78mg · l–1, AUC(08 h) 33.9mg · h · l–1, AUC=39.3 mg · h · l–1, t1/2=2.35 h, Vz=0.319 l · kg–1, CL=0.094 l · h–1 · kg–1. Renal clearance was 14 ml · h–1. kg–1. 33% of the TA dose was recovered in the 24 h urine, 48% of which was conjugated, whereas in adults, TA is only found in urine as conjugates.The apparent plasma clearance was significantly higher (56%) than in 12 healthy adults given 1.5 mg · kg–1 TA. Volume of distribution and t1/2 did not significantly differ between children and adults. Since no relationship has been established between plasma TA and either efficacy or toxicity, a different dose regimen cannot be recommended in 3–11 year-old children from that in adults. 相似文献
33.
P. Cortina Greus J. L. Alfonso Sanchez I. Frasquet Pons C. Saiz Sanchez C. Cortes Vizcaino J. I. Gonzalez Arraez A. Sabater Pons S. Ruiz 《European journal of epidemiology》1992,8(6):770-775
After describing the evolution of mortality from ischaemic cardiopathy (IC) in Spain from 1951 to 1986, which is tending to stabilize in some age groups, and from cerebrovascular accidents (CVA), which is clearly declining, an attempt is made to relate these developments to the prevalence of the main risk factors (hypertension, cholesterol, tobacco) associated with IC and CVA. Certain advances, though of a limited number, have been made in recent years in the control of arterial hypertension in Spain, although campaigns on a national scale as in other countries have not been carried out. Regarding alimentary factors, there is an obvious increase in the consumption of food rich in proteins and animal fats, abandoning to a great extent the traditional Mediterranean diet, with health care action being limited to the improvement of nutrition education of the public. Furthermore, the consumption of tobacco has been increasing in Spain during the study period in spite of health legislation in force in recent years.It is therefore deduced that there is no obvious relationship between mortality due to IC and CVA and the prevalence of the main risk factors associated with these diseases, especially when taking into account that preventive actions on a public health level have been very limited.Corresponding author. 相似文献
34.
Survival of Purkinje Cells in Cerebellar Cultures is Increased by Insulin-like Growth Factor I 总被引:4,自引:0,他引:4
Insulin-like growth factor I (IGF-I) is a trophic factor for both neurons and glia. Its presence in the developing and adult cerebellum suggests a role for this growth factor in this area of the brain. Recently, we have described the existence of an IGF-I-containing pathway in afferents of Purkinje neurons arising from the inferior olive. In addition, IGF-I receptors are present in the molecular layer of the cerebellar cortex. These observations prompted us to investigate whether the Purkinje cell is a target for IGF-I. Addition of IGF-I to rat cerebellar cultures produced a 7-fold increase in the number of Purkinje cells (calbindin-positive) together with an increase in the calbindin content of the cultures. IGF-I also doubled the number of surviving neurons and produced a moderate, non-significant increase in [3 H]thymidine incorporation by the cultures. On the other hand, basic fibroblast growth factor (bFGF), which is also present in the cerebellum, produced a dramatic increase in both the proportion of astrocytes and in the mitotic activity of the cultures, without affecting neuron survival. We conclude that IGF-I is a specific promoter of Purkinje cell survival and that its effects differ from those produced by bFGF in fetal cerebellar cultures. These findings reinforce our hypothesis that the Purkinje cell is a target neuron for IGF-I action in the developing cerebellum. 相似文献
35.
J Labarere M Castell M Fourny M Durand J-C Pons 《International journal of gynaecology and obstetrics》2003,83(1):77-84
OBJECTIVES: To estimate whether a 3-day training program for health professionals was followed by changes in maternity ward practices and in the rate of exclusive breastfeeding. METHODS: A retrospective study in the maternity ward of a French university hospital involved two cross-sectional samples of 323 mother-infant pairs in 1997 and 324 in 2000. RESULTS: The rate of exclusive breastfeeding at discharge increased from 15.8% (12.0-20.2) in the before sample to 35.2% (30.0-40.6) in the after sample (P<0.01). This result persisted in the multivariable analysis [adjusted odds ratio, 2.74 (1.72-4.37)]. Infants in the before sample were less likely to be breastfed within 1 h of birth (9.2% vs. 16.9%, P=0.01), to room-in 24 h/day (56.6% vs. 72.6%, P<0.01), and were more likely to receive formula supplementation (77.6% vs. 54.0%, P<0.01). CONCLUSIONS: A training program for health professionals can be effective in improving maternity ward practices and increasing exclusive breastfeeding rate at discharge. 相似文献
36.
37.
Olga Laporta-Hoyos Júlia Ballester-Plané David Leiva Teresa Ribas Júlia Miralbell Clara Torroja-Nualart Maria Eugenia Russi Esther Toro-Tamargo Mar Meléndez-Plumed Francisca Gimeno Alfons Macaya Roser Pueyo 《European journal of paediatric neurology》2019,23(4):546-559
AimTo comprehensively describe intellectual and executive functioning (EF) in people with dyskinetic cerebral palsy (DCP), by comparing their performance with that of: 1) age- and sex-matched typically developing controls (TDC); and 2) participants with spastic cerebral palsy (SCP) matched for age, sex, term/preterm and gross motor function classification system (GMFCS).MethodThis cross-sectional study was conducted by the University of Barcelona in collaboration with five institutions. Participants were people with DCP (n = 52; 24 females, median age 20.5 y: 5mo, interquartile range [IQR] = 13.75 y: 7mo; GMFCS I–V). As comparison groups, participants with SCP (n = 20; 10 females, median age = 20.5 y: 5.5mo, IQR = 13.75 y 9mo; GMFCS I–V) and TDC (n = 52; 24 females, median age = 20 y: 4mo, IQR = 12 y 7mo) were included. Intelligence and EF were assessed using common tests in all participants.ResultsBoth CP groups had lower intelligence than TDC and performed poorer in almost all EF tasks. Intelligence was higher in DCP than SCP (z = ?2.51, p = 0.01). Participants with DCP also performed significantly better in goal-setting tasks (z = 2.27, p = 0.03) and information processing (z = ?2.54, p = 0.01) than those with SCP.ConclusionPeople with DCP present lower general intellectual functioning and poorer EF across multiple domains than typically developing controls. People with DCP have higher general intellectual functioning and better EF than people with SCP when levels of motor severity are similar. 相似文献
38.
39.
Maria Isabel Fernández-San-Martín Luis Miguel Martín-López Roser Masa-Font Noemí Olona-Tabueña Yuani Roman Jaume Martin-Royo Silvia Oller-Canet Susana González-Tejón Luisa San-Emeterio Albert Barroso-Garcia Lidia Viñas-Cabrera Gemma Flores-Mateo 《Community mental health journal》2014,50(1):81-95
Patients with severe mental illness have higher prevalences of cardiovascular risk factors (CRF). The objective is to determine whether interventions to modify lifestyles in these patients reduce anthropometric and analytical parameters related to CRF in comparison to routine clinical practice. Systematic review of controlled clinical trials with lifestyle intervention in Medline, Cochrane Library, Embase, PsycINFO and CINALH. Change in body mass index, waist circumference, cholesterol, triglycerides and blood sugar. Meta-analyses were performed using random effects models to estimate the weighted mean difference. Heterogeneity was determined using i2 statistical and subgroups analyses. 26 studies were selected. Lifestyle interventions decrease anthropometric and analytical parameters at 3 months follow up. At 6 and 12 months, the differences between the intervention and control groups were maintained, although with less precision. More studies with larger samples and long-term follow-up are needed. 相似文献
40.
Barbara Bellmann Patrick Nagel Verena Tscholl Mattias Roser Andreas Rillig 《Herzschrittmachertherapie & Elektrophysiologie》2016,27(2):156-160
We report a 49-year-old patient who presented with tachycardia in our emergency room. The 12-lead ECG showed a wide complex tachycardia with a heart rate of 234 beats per minute. After structural heart disease was excluded via echocardiography, coronary angiography and magnetic resonance imaging, an electrophysiological study was performed. During programmed ventricular stimulation, a fascicular tachycardia was induced, which was successfully treated by radiofrequency ablation. Fascicular ventricular tachycardia is a rare tachycardia that occurs in patients without structural heart disease. Radiofrequency ablation can be performed safely and shows a high success rate. Differential diagnoses of fascicular ventricular tachycardias are substrate-based ventricular tachycardia and supraventricular tachycardia. 相似文献