全文获取类型
收费全文 | 2014篇 |
免费 | 138篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 56篇 |
妇产科学 | 59篇 |
基础医学 | 295篇 |
口腔科学 | 36篇 |
临床医学 | 228篇 |
内科学 | 452篇 |
皮肤病学 | 39篇 |
神经病学 | 151篇 |
特种医学 | 69篇 |
外科学 | 287篇 |
综合类 | 28篇 |
一般理论 | 1篇 |
预防医学 | 164篇 |
眼科学 | 23篇 |
药学 | 120篇 |
中国医学 | 2篇 |
肿瘤学 | 142篇 |
出版年
2023年 | 18篇 |
2022年 | 31篇 |
2021年 | 68篇 |
2020年 | 35篇 |
2019年 | 59篇 |
2018年 | 76篇 |
2017年 | 52篇 |
2016年 | 57篇 |
2015年 | 58篇 |
2014年 | 77篇 |
2013年 | 128篇 |
2012年 | 151篇 |
2011年 | 175篇 |
2010年 | 90篇 |
2009年 | 84篇 |
2008年 | 101篇 |
2007年 | 123篇 |
2006年 | 104篇 |
2005年 | 75篇 |
2004年 | 76篇 |
2003年 | 70篇 |
2002年 | 58篇 |
2001年 | 35篇 |
2000年 | 47篇 |
1999年 | 29篇 |
1998年 | 17篇 |
1997年 | 13篇 |
1996年 | 8篇 |
1995年 | 8篇 |
1994年 | 7篇 |
1992年 | 20篇 |
1991年 | 15篇 |
1990年 | 18篇 |
1989年 | 9篇 |
1988年 | 13篇 |
1987年 | 14篇 |
1986年 | 15篇 |
1985年 | 8篇 |
1984年 | 10篇 |
1983年 | 6篇 |
1982年 | 5篇 |
1981年 | 10篇 |
1979年 | 5篇 |
1976年 | 5篇 |
1975年 | 6篇 |
1973年 | 7篇 |
1972年 | 7篇 |
1969年 | 5篇 |
1967年 | 5篇 |
1965年 | 5篇 |
排序方式: 共有2162条查询结果,搜索用时 15 毫秒
31.
Human cystic echinococcosis (hydatid disease) caused by the Echinococcus granulosus tapeworm continues to be a substantial cause of morbidity and mortality in many parts of the world. France is still considered as endemic area, but the current infestation by E. granulosus of intermediate hosts in France remains currently unknown due to the absence of official data reporting for the last 20 years. A 1-year prevalence survey was conducted in the 24 slaughterhouses of ten departments of the South of France. We demonstrate that the E. granulosus parasite is still currently present at low prevalence at slaughterhouses in the study area (4 cases for 100,000 sheep and 3 cases for 100,000 cattle). In addition, we assess the presence of genotype G1 in infected animals and identify for the first time in France genotypes G2 and G3 of E. granulosus sensu stricto. 相似文献
32.
33.
34.
Hassan Aboul Nour Neo Poyiadji Ghada Mohamed Owais K Alsrouji Ahmad-Riad Ramadan Brent Griffith Horia Marin Alex Bou Chebl 《Interventional neuroradiology》2021,27(3):434
Large vessel occlusion in patients on ECMO is challenging to appreciate clinically secondary to sedation or induced paralysis, thus placing more emphasis on neurovascular imaging. However, emergent CTA and CTP are both inaccurate and unreliable in ECMO patients due to altered circuitry and interference with normal physiologic hemodynamics. In this review, the utility of DSA is discussed in evaluating the altered hemodynamics of VA-ECMO circuits and patency of major vasculature. In addition, the potential use of TCD in ECMO patients is discussed. 相似文献
35.
36.
37.
T D Bjornsson M Dryjski J Tluczek R Mennie J Ronan T N Mellin K A Thomas 《Proceedings of the National Academy of Sciences of the United States of America》1991,88(19):8651-8655
Intravascular injury to arteries can result in thickening of the intimal smooth muscle layer adjacent to the lumen by migration and proliferation of cells from the underlying medial smooth muscle layer accompanied by deposition of extracellular matrix. This pathological response, which decreases lumen diameter, might, in part, be the result of the access of smooth muscle cells to plasma and platelet-derived growth factors as a consequence of denudation of the overlying confluent monolayer of vascular endothelial cells. Injured rat carotid arteries were treated by i.v. administration of acidic fibroblast growth factor, a heparin-binding protein that is chemotactic and mitogenic for vascular endothelial cells. The growth factor treatment resulted in dose-dependent inhibition of intimal thickening with parallel promotion of endothelial regeneration over the injured area. Therefore, acidic fibroblast growth factor might be efficacious in the prevention of restenosis caused by intimal thickening following angioplasty in humans. 相似文献
38.
Luis M. Jara Pilar Cortés Germán Bou Jordi Barbé Jesús Aranda 《Antimicrobial agents and chemotherapy》2015,59(7):4318-4320
The effect of antimicrobials on SOS-mediated mutagenesis induction depends on the bacterial species and the antimicrobial group. In this work, we studied the effect of different families of antimicrobial agents used in clinical therapy against Acinetobacter baumannii in the induction of mutagenesis in this multiresistant Gram-negative pathogen. The data showed that ciprofloxacin and tetracycline induce SOS-mediated mutagenesis, whereas colistin and meropenem, which are extensively used in clinical therapy, do not. 相似文献
39.
40.
Maryline Fresquet Thomas A. Jowitt Jennet Gummadova Richard Collins Ronan O’Cualain Edward A. McKenzie Rachel Lennon Paul E. Brenchley 《Journal of the American Society of Nephrology : JASN》2015,26(2):302-313
Phospholipase A2 receptor 1 (PLA2R) is a target autoantigen in 70% of patients with idiopathic membranous nephropathy. We describe the location of a major epitope in the N-terminal cysteine-rich ricin domain of PLA2R that is recognized by 90% of human anti-PLA2R autoantibodies. The epitope was sensitive to reduction and SDS denaturation in the isolated ricin domain and the larger fragment containing the ricin, fibronectin type II, first and second C-type lectin domains (CTLD). However, in nondenaturing conditions the epitope was protected against reduction in larger fragments, including the full-length extracellular region of PLA2R. To determine the composition of the epitope, we isolated immunoreactive tryptic fragments by Western blotting and analyzed them by mass spectrometry. The identified peptides were tested as inhibitors of autoantibody binding to PLA2R by surface plasmon resonance. Two peptides from the ricin domain showed strong inhibition, with a longer sequence covering both peptides (31-mer) producing 85% inhibition of autoantibody binding to PLA2R. Anti-PLA2R antibody directly bound this 31-mer peptide under nondenaturing conditions and binding was sensitive to reduction. Analysis of PLA2R and the PLA2R-anti-PLA2R complex using electron microscopy and homology-based representations allowed us to generate a structural model of this major epitope and its antibody binding site, which is independent of pH-induced conformational change in PLA2R. Identification of this major PLA2R epitope will enable further therapeutic advances for patients with idiopathic membranous nephropathy, including antibody inhibition therapy and immunoadsorption of circulating autoantibodies. 相似文献